Dynamic Waveband Switching in WDM Mesh Networks Based on a Generic Auxiliary Graph Model

Waveband switching (WBS) is a promising technique to reduce the switching and transmission costs in the optical domain of a wavelength-division multiplexing (WDM) network. This paper considers the problem of provisioning dynamic traffic using WBS in a WDM mesh network. The network of interest is a homogeneous WBS network, where each node has the functionality of WBS. The problem is called the dynamic WBS problem, which involves searching waveband-routes or wavelength-routes for the dynamically arriving traffic requests. The objective is to minimize the total switching and transmission costs in the optical domain. To solve the dynamic WBS problem, an auxiliary graph model capturing the network state is proposed. Based on the auxiliary graph, two heuristic on-line WBS algorithms with different waveband grouping policies are proposed, namely the wavelength-first WBS algorithm based on the auxiliary graph (WFAUG) and the waveband-first WBS algorithm based on the auxiliary graph (BFAUG). Simulation results indicate that WBS is an attractive technique which reduces the overall switching and transmission costs by up to 30% in the network. The results also show that the WFAUG algorithm outperforms the BFAUG algorithm in terms of port savings and cost savings.     

Perceived risk and trust associated with purchasing at electronic marketplaces

Understanding consumer behaviour is of vital importance to consumer-oriented e-business models today. In this paper, we study the relationships between consumer perceptions of risk and trust and the attitude towards purchasing at a consumer-to-consumer electronic marketplace (EM). Typical for EM settings is that consumer behaviour is subject to perceptions of the selling party as well as of the institutional structures of the intermediary that is operating the EM. Building upon the well-established literature of trust, we consider the concepts of intermediary trust and seller trust. We extend this categorisation by introducing the concepts of intermediary risk and seller risk. We developed measurement instruments for intermediary risk and seller risk. All measurement scales have acceptable alphas and are unidimensional. An empirical study is conducted to explore the relationships between the risk and trust types and consumer purchase attitude. The results reveal significant, direct effects of seller trust and seller risk. Second-order effects of intermediary trust and intermediary risk are investigated and reported. The paper concludes with general observations and recommendations for research and practice.     

Antibody-IL-2 fusion proteins: a novel strategy for immune protection

Advances in genetic engineering and expression systems have led to a rapid progress in the development of immunoglobulins fused to other proteins. These 'antibody fusion proteins' have novel properties and include antibodies fused to the cytokine interleukin-2. In the present review we describe strategies for construction of these antibody-interleukin-2 fusion proteins and discuss their in vitro and in vivo properties. Antibody-interleukin-2 fusion proteins retain both antibody associated functions such as antigen binding, complement activation and Fc gamma receptor binding as well as interleukin-2 associated functions such as the stimulation of proliferation of CTLL2 cells. In vivo, they produce strong potentiation of the host immune response against any associated antigen. In addition, these novel molecules are able to target tumor cells and produce a specific and effective T cell response capable of eliminating the tumor. These properties suggest that antibody-interleukin-2 fusion proteins will be useful in the diagnosis and/or treatment of human cancer as well as in the potentiation of human response against any associated antigen.     

Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1 genes: update with new sequences

Since we published a phylogenetic analysis of the CYP1A subfamily in 1995, several additional full-length sequences have been reported, including three members of an entirely new subfamily, CYP1B. Two avian sequences were recently published, so that CYP1A sequence data are now available from three of the five major vertebrate lineages. The two new branches that have been added to the CYP1 family tree significantly add to our understanding of P450 evolution. The inclusion of the CYP1Bs to the phylogenetic analysis allows us to root inferred trees. Addition of the avian CYP1As indicates that the CYP1A1/CYP1A2 duplication present in the mammalian lineage may have occurred after the divergence of birds and mammals. The number of fish species from which full-length coding regions of CYP1A genes have been sequenced has increased from four (trout, plaice, toadfish, and scup) to nine. These include CYP1A sequences from tomcod, butterflyfish, sea bream, sea bass, and the full-length sequence of CYP1A from the killifish Fundulus heteroclitus that is reported here. Phylogenetic analyses incorporating the new fish CYP1A sequences support our original conclusion that the fish CYP1As are monophyletic and indicate that the genes are evolving at very different rates in different species.     

Postoperative radiation for squamous cell carcinoma metastatic to cervical lymph nodes from an unknown primary site: outcomes and patterns of failure

BACKGROUND: This retrospective study assesses the outcomes and patterns of failure in patients with squamous cell carcinoma metastatic to cervical lymph nodes from an unknown primary site treated with combined surgery and postoperative radiotherapy. METHODS: One hundred thirty-six patients with squamous cell carcinoma metastatic to cervical lymph nodes from an unknown primary source were treated postoperatively with radiotherapy at the University of Texas M. D. Anderson Cancer Center between the years 1968 and 1992. Stage distribution was: N1, 31 patients; N2a, 49; N2b, 25; N2c, 3; N3, 18; and Nx, 10. Thirty-nine patients had excisional biopsies only, 64 patients underwent modified neck dissections, and 33 had radical neck dissections. Extracapsular extension was present in 87 cases. Fifty-nine patients had multiple nodes involved. The median duration of follow-up for surviving patients was 8.7 years. RESULTS: Twelve patients, all with extracapsular nodal disease, developed regional relapse. The 5-year actuarial rates of regional relapse in patients with and without extracapsular nodal disease were 16% and 0%, respectively (p = .004). Nine patients (22%) with extracapsular disease and multiple nodes relapsed compared with three patients (7%) with extracapsular disease and a solitary node (p = .02). None of the patients treated with excisional biopsy and radiotherapy relapsed regionally. No statistically significant relationship between dose, treatment duration, time interval between surgery, and the start of radiotherapy and relapse was detected. The 2-, 5-, and 10-year actuarial disease-specific survival rates were 82%, 74%, and 68%, respectively. Fourteen patients developed cancers in head and neck mucosal sites; six of these cancers were located in unirradiated tissues. CONCLUSIONS: Relapse occurred infrequently in patients treated with excisional biopsies and postoperative radiotherapy. Extracapsular extension and multiple nodes were associated with worse regional control and disease-specific survival. These results appear consistent with those expected for patients with advanced neck disease and a known primary site, and the absence of a primary site should not exclude patients from studies aiming to improve outcomes in patients with extensive neck disease from a head and neck squamous cell cancer. We continue to recommend radiation to the necks and pharyngeal axis for patients suspected of having residual microscopic disease following surgery for squamous cell carcinoma metastatic to the neck from an unknown primary site.     

Boron removal by titanium addition in solidification refining of silicon with Si-Al melt

In order to effectively remove B from Si for its use in solar cells, a process involving B removal by solidification refining of Si using a Si-Al melt with Ti addition was investigated. For clarifying the effect of Ti addition on B removal from the Si-Al melt, TiB₂ solubilities in Si-64.6 at. pct Al melt at 1173 K and Si-60.0 at. pct Al melt at 1273 K were determined by measuring the equilibrium concentrations of B and Ti in the presence of TiB₂ precipitates. The small solubilities of TiB₂ in the Si-Al melt indicate the effective removal of B from the Si-Al melt by Ti addition. Further, solidification experiments of Si-Al alloys containing B by Ti addition were performed, and the effect of Ti addition on the solidification refining of Si with the Si-Al melt was successfully confirmed.     

An explanation of disproportionate growth using linear 3-dimensional informetrics and its relation with the fractal dimension

Summary We study new and existing data sets which show that growth rates of sources usually are different from growth rates of items. Examples: references in publications grow with a rate that is different (usually higher) from the growth rate of the publications themselves; article growth rates are different from journal growth rates and so on. In this paper we interpret this phenomenon of “disproportionate growth' in terms of Naranan's growth model and in terms of the self-similar fractal dimension of such an information system, which follows from Naranan's growth model. The main part of the paper is devoted to explain disproportionate growth. We show that the “simple' 2-dimensional informetrics models of source-item relations are not able to explain this but we also show that linear 3-dimensional informetrics (i.e. adding a new source set) is capable to model disproportionate growth. Formulae of such different growth rates are presented using Lotkaian informetrics and new and existing data sets are presented and interpreted in terms of the used linear 3-dimensional model.     

Application of Differential Evolution for Irrigation Planning: An Indian Case Study

The present paper demonstrates the applicability of population based search optimization method, namely, Differential Evolution (DE) to a case study of Mahi Bajaj Sagar Project (MBSP), India. Ten different strategies of DE are employed to assess the ability of DE for solving higher dimensional problems as an alternative methodology for irrigation planning. The parameters considered in DE are population size, crossover constant and weighting factor. Linear Programming (LP) is utilized as a comparative approach to assess the ability of DE. Comparison of results of LP and the 10 DE strategies for the given parameters indicated that both the results are comparable even for high dimensional problems. Extensive sensitivity analysis studies, performed for 3,600 combinations of above parameters for the 10 DE strategies suggested that DE/rand-to-best/1/bin strategy is the best strategy giving maximum benefits taking minimum CPU time. It is concluded that DE can be utilized for efficient planning of any irrigation system with suitable modifications.