Chlorpropamide-induced hypoglycemia: successful treatment with diazoxide

A healthy adolescent boy was treated on two occasions for an overdose of chlorpropamide (Diabinese). Glucose therapy alone was not sufficient to control the hypoglycemia, but the administration of glucose plus diazoxide raised the blood sugar to supranormal levels. A bolus of intravenous glucagon briefly raised the blood sugar level to within normal limits, increased the blood ketones but also augmented insulin secretion. An overdose of sulfonylurea may cause prolonged and fatal hypoglycemia. Rational therapy, both in diabetic and normal persons, is glucose plus an "insulin antagonist." The administration of diazoxide was effective in our patient, substantially reducing the plasma insulin level; this agent may be the "insulin-antagonist" of choice for use in sulfonylurea-induced hypoglycemia.     

Approximating total citation counts from first author counts and from total papers

This paper is an attempt to improve on the approximation. First author citations (C_f)≈Total citations (C_t) of an author's publications without the work of making the complete citation count under the author and all co-author names. Using the bibliographies of all faculty from each of four large departments: Physics, Chemistry, Materials Sciences, and Biosciences, in the same university, both first author and complete citation counts were made, care being taken to avoid the most common errors in such counts. It is shown that the function C_f·T/F (where T and F are the total number of papers and F those with subject author's name first) correlates strongly (>90%) with C_t. We find also that C_t correlates strongly with T. The data also may be used as one more line of evidence to obtain normalizing ratios for possible comparisons of productivityacross different disciplinary universes. A very tentative ratio from different studies would be 8 (Chem.)=4 (Physics)=2.5 (Mat. Sci.)=2 (Mathematics)=4.5 (Biophysics-Biochemistry).     

Decision support aids with anthropomorphic characteristics influence trust and performance in younger and older adults

This study examined the use of deliberately anthropomorphic automation on younger and older adults' trust, dependence and performance on a diabetes decision-making task. Research with anthropomorphic interface agents has shown mixed effects in judgments of preferences but has rarely examined effects on performance. Meanwhile, research in automation has shown some forms of anthropomorphism (e.g. etiquette) have effects on trust and dependence on automation. Participants answered diabetes questions with no-aid, a non-anthropomorphic aid or an anthropomorphised aid. Trust and dependence in the aid was measured. A minimally anthropomorphic aide primarily affected younger adults' trust in the aid. Dependence, however, for both age groups was influenced by the anthropomorphic aid. Automation that deliberately embodies person-like characteristics can influence trust and dependence on reasonably reliable automation. However, further research is necessary to better understand the specific aspects of the aid that affect different age groups. Automation that embodies human-like characteristics may be useful in situations where there is under-utilisation of reasonably reliable aids by enhancing trust and dependence in that aid. Practitioner Summary: The design of decision-support aids on consumer devices (e.g. smartphones) may influence the level of trust that users place in that system and their amount of use. This study is the first step in articulating how the design of aids may influence user's trust and use of such systems.     

Fibrous myopathy. A rheumatic complication of drug abuse

A progressive fibrous myopathy may result from chronic intramuscular drug abuse. This complication may mimic other rheumatic disorders and early recognition may prevent disability. The patient described here presented with fixed flexion and extension contracture of hips and knees, respectively, after abusing meperidine and other agents for 3 years. Soft tissues of thighs and buttocks were "wood hard," EMG showed absence of action potentials in affected muscles, and biopsy revealed extensive replacement of muscle with dense, acellular fibrous tissue. Possible mechanisms are discussed.     

Ink-Jet Printing System?An Analytical Computer Model

An analytical computer model of an ink jet printing system was created. Based upon the values of 13 input parameters, the program delivers predictions of the forces acting on individual drops and their resulting dynamic behavior. Predictions of drop displacements and flight times were used to infer drop pattern appearance resulting from a given input signal. The computer model was based upon theoretical work plus extensive empirical measurements. Drop behavior was predicted with modest accuracy. An improved understanding of ink jet printing systems and numerous recommendations for their use were also derived in this study.