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排序方式: 共有1110条查询结果,搜索用时 15 毫秒
91.
Dr. Nina Bionda Prof. Dr. Rudi Fasan 《Chembiochem : a European journal of chemical biology》2015,16(14):2011-2016
Methods to access natural‐product‐like macrocyclic peptides can disclose new opportunities for the exploration of this important structural class for chemical biology and drug discovery applications. Here, the scope and mechanism of a novel strategy for directing the biosynthesis of thioether‐bridged bicyclic peptides in bacterial cells was investigated. This method entails split intein‐catalyzed head‐to‐tail cyclization of a ribosomally produced precursor peptide, combined with inter‐side‐chain crosslinking through a genetically encoded cysteine‐reactive amino acid. This strategy could be successfully applied to achieve formation of structurally diverse bicyclic peptides with high efficiency and selectivity in Escherichia coli. Insights into the sequence of reactions underlying the peptide bicyclization process were gained from time‐course experiments. Finally, the potential utility of this methodology toward the discovery of macrocyclic peptides with enhanced functional properties was demonstrated through the isolation of a bicyclic peptide with sub‐micromolar affinity for streptavidin. 相似文献
92.
Artem A. Barabanov Nina V. Semikolenova Michail A. Matsko Ljudmila G. Echevskaya Vladimir A. Zakharov 《Polymer》2010,51(15):3354-1654
The effects of polymerization time and temperature on the molecular weight and molecular weight distribution of polyethylene, produced over homogeneous catalyst bis[N-(3-tert-butyl salicylidene)anilinato]zirconium(IV) dichloride tBu-L2ZrCl2/MAO have been studied. The data on the number of active centers (CP) and propagation rate constants (kP) at different polymerization time have been obtained as well. It was found that at a short polymerization time two types of active centers, producing low molecular weight PE (Mw = (4-10) × 103 g mol−1) are formed. The number of these centers was estimated to be 11% of total zirconium complex and their reactivity is very high (the kP value was found to be 54 × 103 L mol−1 s−1 at 35 °C). High initial activity of the catalyst fell with the increase in polymerization time, whereas the polydispersity values of the resulting PE increase due to formation of new centers, producing high molecular weight PE (Mw = (30-1300) × 103 g mol−1). It was found that the decrease in activity is caused by reducing the initial active centers number and lower reactivity of the new-formed centers (kP = 17 × 103 L mol−1 s−1). 相似文献
93.
94.
Marie-Theres Hutchison Dr. Giovanni Bellomo Dr. Alexey Cherepanov Elke Stirnal Dr. Boris Fürtig Dr. Christian Richter Verena Linhard Elina Gurewitsch Prof. Dr. Moreno Lelli Prof. Dr. Nina Morgner Prof. Dr. Thomas Schrader Prof. Dr. Harald Schwalbe 《Chembiochem : a European journal of chemical biology》2023,24(7):e202200760
The aggregation of amyloid-β 42 (Aβ42) is directly related to the pathogenesis of Alzheimer's disease. Here, we have investigated the early stages of the aggregation process, during which most of the cytotoxic species are formed. Aβ42 aggregation kinetics, characterized by the quantification of Aβ42 monomer consumption, were tracked by real-time solution NMR spectroscopy (RT-NMR) allowing the impact that low-molecular-weight (LMW) inhibitors and modulators exert on the aggregation process to be analysed. Distinct differences in the Aβ42 kinetic profiles were apparent and were further investigated kinetically and structurally by using thioflavin T (ThT) and transmission electron microscopy (TEM), respectively. LMW inhibitors were shown to have a differential impact on early-state aggregation. Insight provided here could direct future therapeutic design based on kinetic profiling of the process of fibril formation. 相似文献
95.
Positively-charged β-lactoglobulin derivatives prepared by amidation or esterification of available carboxyl groups of the native protein were bound strongly by casein micelles. Increasing amounts of these additives progressively decreased rennet coagulation time of casein micelles. Higher concentrations of positively-charged proteins coagulated casein micelles without addition of rennet extract. Of the modified proteins tested, approximately 1.0 g amidated β-lactoglobulin, 2.0 g ethyl-esterified β-lactoglobulin, or 1.0 g methyl-esterified β-lactoglobulin would be required to coagulate 100 ml of casein micelles at concentrations in milk. 相似文献
96.
Gordon H. Dash Jr. Nina Kajiji 《International Transactions in Operational Research》2014,21(6):899-918
A dynamic portfolio policy is one that periodically rebalances an optimally diversified portfolio to account for time‐varying correlations. In order to sustain target‐level Sharpe performance ratios between rebalancing points, the efficient portfolio must be hedged with an optimal number of contingent claim contracts. This research presents a mixed‐integer nonlinear goal program (MINLGP) that is directed to solve the hierarchical multiple goal portfolio optimization model when the decision maker is faced with a binary hedging decision between portfolio rebalance periods. The MINLGP applied to this problem is formed by extending the separable programming foundation of a lexicographic nonlinear goal program (NLGP) to include branch‐and‐bound constraints. We establish the economic efficiency of applying this normative approach to dynamic portfolio rebalancing by comparing the risk‐adjusted performance measures of a hedged optimal portfolio to those of a naively diversified portfolio. We find that a hedged equally weighted small portfolio and a hedged efficiently diversified small portfolio perform similarly when comparing risk‐adjusted return metrics. However, when percentile risk measures are used to measure performance, the hedged optimally diversified portfolio clearly produces less expected catastrophic loss than does its nonhedged and naively diversified counterpart. 相似文献
97.
Biever Joan L.; Gómez John P.; González Cynthia G.; Patrizio Nina 《Canadian Metallurgical Quarterly》2011,5(2):81
The competent delivery of mental health services to Spanish-speaking clients requires knowledge of Latino cultures, racial and ethnic identity development, variables that impact service delivery, and the Spanish language. We present the Psychological Services for Spanish Speaking Populations (PSSSP) program as a model for training mental health professionals to deliver services to Spanish-speaking clients. The goals for the program were to improve participants' oral and written Spanish language proficiency in work-related contexts and to improve multicultural competence in service delivery to Latino clients. Recommendations for those who wish to offer similar programs include (a) grouping trainees according to Spanish language proficiency, (b) using Spanish language instructors with expertise in teaching heritage language learners, and (c) developing criterion references or measures to assess program outcomes. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
98.
Thora Tenbrink Robert J. Ross Kavita E. Thomas Nina Dethlefs Elena Andonova 《Journal of Visual Languages and Computing》2010,21(5):292-309
When conveying information about spatial situations and goals, speakers adapt flexibly to their addressee in order to reach the communicative goal efficiently and effortlessly. Our aim is to equip a dialogue system with the abilities required for such a natural, adaptive dialogue. In this paper we investigate the strategies people use to convey route information in relation to a map by presenting two parallel studies involving human–human and human–computer interaction. We compare the instructions given to a human interaction partner with those given to a dialogue system which reacts by basic verbal responses and dynamic visualization of the route in the map. The language produced by human route givers is analyzed with respect to a range of communicative as well as cognitively crucial features, particularly perspective choice and references to locations across levels of granularity. Results reveal that speakers produce systematically different instructions with respect to these features, depending on the nature of the interaction partner, human or dialogue system. Our further analysis of clarification and reference resolution strategies produced by human route followers provides insights into dialogue strategies that future systems should be equipped with. 相似文献
99.
The heat of wetting for very fine iron powder and its composites with Ag, Pt, Au, Cu, and Zn prepared by a thermochemical method is measured. It is established that their surface is hydrophilic. This makes it possible to modify the surface of powders with different substances and create new materials intended for medicine and technics.
相似文献100.