Thermal conductivity of anisotropic,inhomogeneous high‐density foam calculated from three‐dimensional reconstruction of microtome images

An effective method is developed to predict the thermal conductivity of thick foam insulation on offshore oil and gas pipelines. High‐resolution three‐dimensional (3D) images (212 megavoxels) spanning macroscopic sample volumes (38 × 19 × 4 mm³) are obtained and used to create a 3D geometry of the foam. A gravimetric technique is developed to measure the mass density through the foam thickness and used to verify the 3D geometry. The local anisotropic thermal conductivity through the thickness of the foam is calculated using the finite element method on the 3D geometry and the results are verified against measurements and found to be in good agreement. Results show that thermal conductivity is dependent on morphology. For the highly anisotropic part of the foam where the long axes of the bubbles are oriented parallel to the axial direction of the pipe, the radial thermal conductivity is lowered significantly compared to more isotropic foam. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 1020‐1028, 2013     

IL-17 Pathway Members as Potential Biomarkers of Effective Systemic Treatment and Cardiovascular Disease in Patients with Moderate-to-Severe Psoriasis

Psoriasis is a chronic inflammatory condition associated with atherosclerotic cardiovascular disease (CVD). Systemic anti-psoriatic treatments mainly include methotrexate and biological therapies targeting TNF, IL-12/23 and IL-17A. We profiled plasma proteins from patients with moderate-to-severe psoriasis to explore potential biomarkers of effective systemic treatment and their relationship to CVD. We found that systemically well-treated patients (PASI < 3.0, n = 36) had lower circulating levels of IL-17 pathway proteins compared to untreated patients (PASI > 10, n = 23). Notably, IL-17C and PI3 were decreased with all four examined systemic treatment types. Furthermore, in patients without CVD, we observed strong correlations among IL-17C/PI3/PASI (r ≥ 0.82, p ≤ 1.5 × 10⁻¹²) pairs or between IL-17A/PASI (r = 0.72, p = 9.3 × 10⁻⁸). In patients with CVD, the IL-17A/PASI correlation was abolished (r = 0.2, p = 0.24) and the other correlations were decreased, e.g., IL-17C/PI3 (r = 0.61, p = 4.5 × 10⁻⁵). Patients with moderate-to-severe psoriasis and CVD had lower levels of IL-17A compared to those without CVD (normalized protein expression [NPX] 2.02 vs. 2.55, p = 0.013), and lower IL-17A levels (NPX < 2.3) were associated with higher incidence of CVD (OR = 24.5, p = 0.0028, 95% CI 2.1–1425.1). As a result, in patients with moderate-to-severe psoriasis, we propose circulating IL-17C and PI3 as potential biomarkers of effective systemic anti-psoriatic treatment, and IL-17A as potential marker of CVD.     

Commentary on: “Indicators of European public research in hydrogen and fuel cells—an input–output analysis”

The output of European public research in hydrogen and fuel cells in terms of number of publications is reported in the paper by Seymour et al. [Indicators of European public research in hydrogen and fuel cells—An input–output analysis. Int J Hydrogen Energy 2007; 32(15): 3212–22]. The counting method for publications is not stated but whole counting has been used. It is not mentioned that the rankings of different countries might have changed if other counting methods had been used. The paper also reports measurements of citations based on the publications counted. The difference in results obtained by using different counting methods will be larger for citations but this is not mentioned. The values for the number of publications for the European countries have been added to provide the value for EU+$\mathrm{EU}+$. However, values obtained by whole counting for individual countries cannot be added to provide correct values for a union of these countries. Therefore the comparison reported in the paper between the publication output for EU+$\mathrm{EU}+$ and for US, Japan and China is invalid.     

Creep crack growth in welded components — a numerical study and comparison with the R5 procedures

In the present study, creep crack growth (CCG) in a circumferentially welded low alloyed pipe is numerically investigated for a number of different combinations of weldment constituent material properties. A creep ductility based damage model describes the accumulation of creep damage ahead of the crack tip where a constraint parameter and the creep strain rate perpendicular to the crack plane are used as characterising parameters. It is assumed that a fully circumferential creep crack, located in the heat affected zone with a depth of one quarter of the pipe thickness, is growing at a constant rate from the outer surface towards the inside. The numerical results reveal that not only the properties of the zone containing the crack, but also the deformation properties of the surrounding material influence the CCG behaviour. This influence can be noted on the characterising parameters used for the CCG rate predictions as well as on the CCG rate itself. The mismatch influence on corresponding C^* values is, however, marginal. This indicates that determination of the CCG rate in weldments, based on the C^* value only, may result in uncertain estimates.The numerically investigated cases are also assessed by use of the R5 procedures for the sake of comparison. Considering the stress re-distribution, due to the mismatch effect, the CCG rate is determined for the different weldment configurations. The comparison shows that the assumption of plane strain or plane stress conditions in the R5 analysis is essential for the agreement of the results between R5 and the two-parameter approach. Assuming plane stress conditions at the crack tip results in a relatively good agreement for the axial stress dominated cases investigated. However, for the hoop stress dominated cases, the R5 procedures predict higher CCG rates by an order of magnitude.     

The degradation of phytate by microbial and wheat phytases is dependent on the phytate matrix and the phytase origin

BACKGROUND: Phytases increase utilization of phytate phosphorus in feed. Since wheat is rich in endogenous phytase activity it was examined whether wheat phytases could improve phytate degradation compared to microbial phytases. Moreover, it was investigated whether enzymatic degradation of phytate is influenced by the matrix surrounding it. Phytate degradation was defined as the decrease in the sum of InsP₆ + InsP₅. RESULTS: Endogenous wheat phytase effectively degraded wheat InsP₆ + InsP₅ at pH 4 and pH 5, while this was not true for a recombinant wheat phytase or phytase extracted from wheat bran. Only microbial phytases were able to degrade InsP₆ + InsP₅ in the entire pH range from 3 to 5, which is relevant for feed applications. A microbial phytase was efficient towards InsP₆ + InsP₅ in different phytate samples, whereas the ability to degrade InsP₆ + InsP₅ in the different phytate samples ranged from 12% to 70% for the recombinant wheat phytase. CONCLUSION: Wheat phytase appeared to have an interesting potential. However, the wheat phytases studied could not improve phytate degradation compared to microbial phytases. The ability to degrade phytate in different phytate samples varied greatly for some phytases, indicating that phytase efficacy may be affected by the phytate matrix. Copyright © 2011 Society of Chemical Industry     

Emission of di-2-ethylhexyl phthalate from PVC flooring into air and uptake in dust: emission and sorption experiments in FLEC and CLIMPAQ

The emission of di-2-ethylhexyl phthalate (DEHP) from a PVC flooring was studied for up to 472 days in both the FLEC (Field and Laboratory Emission Cell) and the CLIMPAQ (Chamberfor Laboratory Investigations of Materials, Pollution, and Air Quality). The loading of the CLIMPAQs was varied but was constant in the FLECs. The sorption properties of FLEC and CLIMPAQ were investigated using different methods. In addition, the uptake of DEHP by office floor dust on the PVC flooring was studied in CLIMPAQ experiments. The concentration versus time curves in both FLECs and CLIMPAQs increased slowly over about 150 days and reached a quasi-static equilibrium at 1 microg m(-3). The main conclusions were that (i) the emission rate of DEHP was limited by gas-phase mass transport and (ii) the dust layer increased the emission rate by increasing the external concentration gradient above the surface of the PVC. These conclusions were based on the facts that the specific emission rate was inversely proportional to the loading and that the dust had sorbed about four times as much DEHP over a 68-day period as emitted in the gas-phase experiments. About one-half of the emitted DEHP was deposited on the internal surfaces of both the FLEC and the CLIMPAQ.     

Investigation of D₂ receptor-agonist interactions using a combination of pharmacophore and receptor homology modeling

A combined modeling approach was used to identify structural factors that underlie the structure-activity relationships (SARs) of full dopamine D? receptor agonists and structurally similar inactive compounds. A 3D structural model of the dopamine D? receptor was constructed, with the agonist (-)-(R)-2-OH-NPA present in the binding site during the modeling procedure. The 3D model was evaluated and compared with our previously published D? agonist pharmacophore model. The comparison revealed an inconsistency between the projected hydrogen bonding feature (Ser-TM5) in the pharmacophore model and the TM5 region in the structure model. A new refined pharmacophore model was developed, guided by the shape of the binding site in the receptor model and with less emphasis on TM5 interactions. The combination of receptor and pharmacophore modeling also identified the importance of His393?·?? for agonist binding. This convergent 3D pharmacophore and protein structure modeling strategy is considered to be general and can be highly useful in less well-characterized systems to explore ligand-receptor interactions. The strategy has the potential to identify weaknesses in the individual models and thereby provides an opportunity to improve the discriminating predictivity of both pharmacophore searches and structure-based virtual screens.     

Emissions of soot,PAHs, ultrafine particles,NOx, and other health relevant compounds from stressed burning of candles in indoor air

Burning candles release a variety of pollutants to indoor air, some of which are of concern for human health. We studied emissions of particles and gases from the stressed burning of five types of pillar candles with different wax and wick compositions. The stressed burning was introduced by controlled fluctuating air velocities in a 21.6 m³ laboratory chamber. The aerosol physicochemical properties were measured both in well-mixed chamber air and directly above the candle flame with online and offline techniques. All candles showed different emission profiles over time with high repeatability among replicates. The particle mass emissions from stressed burning for all candle types were dominated by soot (black carbon; BC). The wax and wick composition strongly influenced emissions of BC, PM_2.5, and particle-phase polycyclic aromatic hydrocarbons (PAHs), and to lower degree ultrafine particles, inorganic and organic carbon fraction of PM, but did not influence NO_x, formaldehyde, and gas-phase PAHs. Measurements directly above the flame showed empirical evidence of short-lived strong emission peaks of soot particles. The results show the importance of including the entire burn time of candles in exposure assessments, as their emissions can vary strongly over time. Preventing stressed burning of candles can reduce exposure to pollutants in indoor air.