Impaired timing precision produced by striatal D2 receptor overexpression is mediated by cognitive and motivational deficits.

Increased striatal dopamine D2 receptor activity is thought to contribute to the pathophysiology of schizophrenia. To model this condition in mice, Kellendonk et al. (2006) generated transgenic mice that selectively overexpress the D2 receptor in striatum (D2OE). Drew et al. (2007) reported that D2OE mice display deficits in interval timing and motivation. The present study further explored the impaired timing in D2OE mice. Experiment 1 assessed the role of motivation in producing timing deficits in the peak procedure and found that performance in D2OE mice was improved by increasing motivation. In addition, performance was impaired in control mice when motivation was decreased. In Experiment 2, we found that D2OE mice have no timing impairment when tested using the bisection task, a procedure in which the measure of timing performance is less influenced by motivation to respond. In Experiment 3, we also used the bisection task and found selective impairment in timing of long durations in D2OE mice. These results suggest that striatal D2 overexpression impairs timing by decreasing motivation and through its impact on working memory and/or sustained attention. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Representing Epistemic Uncertainty by Means of Dialectical Argumentation

We articulate a dialectical argumentation framework for qualitative representation of epistemic uncertainty in scientific domains. The framework is grounded in specific philosophies of science and theories of rational mutual discourse. We study the formal properties of our framework and provide it with a game theoretic semantics. With this semantics, we examine the relationship between the snaphots of the debate in the framework and the long run position of the debate, and prove a result directly analogous to the standard (Neyman–Pearson) approach to statistical hypothesis testing. We believe this formalism for representating uncertainty has value in domains with only limited knowledge, where experimental evidence is ambiguous or conflicting, or where agreement between different stakeholders on the quantification of uncertainty is difficult to achieve. All three of these conditions are found in assessments of carcinogenic risk for new chemicals.     

Fast string matching for multiple searches

We present a string matching or pattern matching method which is especially useful when a single block of text must be searched repeatedly for different patterns. The method combines linking the text according to digrams, searching on the least‐frequent digram, and probing selected characters as a preliminary filter before full pattern comparison. Tests on real alphabetic data show that the number of character comparisons may be decreased by two orders of magnitude compared with Knuth–Morris–Pratt and similar searching, but with an initialization overhead comparable to five to ten conventional searches. Copyright © 2001 John Wiley & Sons, Ltd.     

Patrick H. Samway,ed., A Thief of Peirce: The Letters of Walker Percy and Kenneth Laine Ketner

Minds and Machines -     

Cofiring of Thin Zirconia Films During SOFC Manufacturing

High-performance solid oxide fuel cells require a thin and gas-tight electrolyte membrane that must be coated on a porous and relatively rough support. A pretreatment of the delivered submicronmeter electrolyte powder of 8 mol%-yttria-stabilized zirconia (8YSZ) yielded a reduced sintering mismatch between the anode substrate made from NiO/8YSZ and the electrolyte coating. Furthermore, it also enhanced the powder packing inside the green film. Constrained sintering usually leads to inadequate film density and an unfavorable pore deformation and orientation. It was demonstrated that these limitations can be resolved by using a coshrinking substrate in a planar cell design. Relative densities of >97% were achieved, which are higher than those for free-standing layers. Additionally, the camber behavior was investigated in dependence of the temperature program with and without gravity effects, giving an overall suggestion for the cofiring parameters of the electrolyte.     

The effects of social category norms and stereotypes on explanations for intergroup differences.

A 2-stage model of the construction of explanations for differences between groups is presented. Category norms affect which of 2 groups becomes "the effect to be explained," and stereotypes shape attributions about that group. In 3 experiments, 288 participants wrote explanations for differences between gay and straight men. Explanations focused on gay men who were also judged to have more mutable attributes. However, these effects were not correlated. Participants focused explanations on straight men when explicitly instructed to do so (Experiment 1). Explanations focused on both groups equally when the gay men constituted the numerically larger sample, when gay men were more typical of the overarching category (i.e., people with AMS) than straight men, or when more straight men were described as performing the behavior (Experiment 2). Stereotype-consistent information prompted more essentialist references and fewer reconstructive references to gay men than did stereotype-inconsistent information (Experiment 3). The relevance of this model for theories of norms, stereotypes, and for the conduct of social science is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)