Smoothing the trail for dissemination of evidence-based practices for youth: Flexibility within fidelity.

The role and implementation of evidence-based practice and empirically supported treatments has been hotly contested among researchers and practitioners. Using examples of and from various empirically supported treatments the authors offer suggestions for smoothing the pathway for dissemination of evidence-based practice with children and adolescents. The authors underscore that mediational analyses, treatment process studies, and the continued creation of flexible treatment manuals are important components of successful dissemination. Flexibility within fidelity is proposed as the preferred perspective that eases the transition and dissemination of empirically supported treatments from research clinics to service clinics. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Utility of R0 as a predictor of disease invasion in structured populations

Early theoretical work on disease invasion typically assumed large and well-mixed host populations. Many human and wildlife systems, however, have small groups with limited movement among groups. In these situations, the basic reproductive number, R0, is likely to be a poor predictor of a disease pandemic because it typically does not account for group structure and movement of individuals among groups. We extend recent work by combining the movement of hosts, transmission within groups, recovery from infection and the recruitment of new susceptibles into a stochastic model of disease in a host metapopulation. We focus on how recruitment of susceptibles affects disease invasion and how population structure can affect the frequency of superspreading events (SSEs). We show that the frequency of SSEs may decrease with the reduced movement and the group sizes due to the limited number of susceptible individuals available. Classification tree analysis of the model results illustrates the hierarchical nature of disease invasion in host metapopulations. First, the pathogen must effectively transmit within a group (R0>1), and then the pathogen must persist within a group long enough to allow for movement among the groups. Therefore, the factors affecting disease persistence--such as infectious period, group size and recruitment of new susceptibles--are as important as the local transmission rates in predicting the spread of pathogens across a metapopulation.     

DNA double-strand break repair: a theoretical framework and its application

DNA double-strand breaks (DSBs) are formed as a result of genotoxic insults, such as exogenous ionizing radiation, and are among the most serious types of DNA damage. One of the earliest molecular responses following DSB formation is the phosphorylation of the histone H2AX, giving rise to γH2AX. Many copies of γH2AX are generated at DSBs and can be detected in vitro as foci using well-established immuno-histochemical methods. It has previously been shown that anti-γH2AX antibodies, modified by the addition of the cell-penetrating peptide TAT and a fluorescent or radionuclide label, can be used to visualize and quantify DSBs in vivo. Moreover, when labelled with a high amount of the short-range, Auger electron-emitting radioisotope, ¹¹¹In, the amount of DNA damage within a cell can be increased, leading to cell death. In this report, we develop a mathematical model that describes how molecular processes at individual sites of DNA damage give rise to quantifiable foci. Equations that describe stochastic mean behaviours at individual DSB sites are derived and parametrized using population-scale, time-series measurements from two different cancer cell lines. The model is used to examine two case studies in which the introduction of an antibody (anti-γH2AX-TAT) that targets a key component in the DSB repair pathway influences system behaviour. We investigate: (i) how the interaction between anti-γH2AX-TAT and γH2AX effects the kinetics of H2AX phosphorylation and DSB repair and (ii) model behaviour when the anti-γH2AX antibody is labelled with Auger electron-emitting ¹¹¹In and can thus instigate additional DNA damage. This work supports the conclusion that DSB kinetics are largely unaffected by the introduction of the anti-γH2AX antibody, a result that has been validated experimentally, and hence the hypothesis that the use of anti-γH2AX antibody to quantify DSBs does not violate the image tracer principle. Moreover, it provides a novel model of DNA damage accumulation in the presence of Auger electron-emitting ¹¹¹In that is supported qualitatively by the available experimental data.     

Harnessing information for development: A proposal for a world bank group vision and strategy∗

Abstract

Revolutionary advances in information technology reinforce economic and social changes that are transforming business and society. A new kind of economy ‐ the information economy ‐ is emerging where trade and investment are global and firms compete with knowledge, networking and agility on a global basis. A corresponding new society is also emerging with pervasive information capabilities that make it substantially different from an industrial society: more competitive, more democratic, less centralized, less stable, better able to address individual needs, and friendlier to the environment.

These changes dictate, for all countries, a major adjustment to harness information for economic and social development. This adjustment requires urgent new policies, regulatory and institutional reforms, and investments. Through this adjustment, countries must achieve macroeconomic balance, political stability, and growth amidst global information flows, competition, trade, and investment. Advanced countries are rapidly adjusting. Developing countries must also adjust or risk exclusion from the global economy and severe competitive disadvantage for their goods and services.

Fortunately, the information revolution creates both the challenge and the means for countries to adjust to new ways of doing business and to put in place the needed infrastructure of telecommunications and information systems. The information revolution also creates extraordinary new opportunities to attack vexing problems of poverty, inequality, and environmental degradation.

To harness information and information technology for its mission of poverty alleviation and sustainable economic development, the World Bank Group will pursue four objectives in its assistance strategy:

• Widespread and equitable access to communication and information services through accelerated deployment of national information infrastructure and effective integration into international communication and information networks.

• Systemic improvements in the functioning and competitiveness of key economic sectors through strategic information policies and systems.

• New ways to use information technology to help solve the most pressing problems of human and economic development ‐ education, health, poverty alleviation, rural development, and care for the environment.

• Increased impact of the entire range of World Bank Group operations through inclusion of effective information components.

The World Bank Group will be a long‐term partner and facilitator for countries adjusting to the information economy. It will cooperate with them on information policy, strategy, and project design at the national and sectoral levels. To this end, it will develop strategic alliances to mobilize worldwide knowledge and financing, including its own. In addition, the World Bank Group will increase the level and effectiveness of the information content of its projects in all sectors and will explore new frontiers of development through information‐intensive projects.     

Building facade detection,segmentation, and parameter estimation for mobile robot stereo vision

Building facade detection is an important problem in computer vision, with applications in mobile robotics and semantic scene understanding. In particular, mobile platform localization and guidance in urban environments can be enabled with accurate models of the various building facades in a scene. Toward that end, we present a system for detection, segmentation, and parameter estimation of building facades in stereo imagery. The proposed method incorporates multilevel appearance and disparity features in a binary discriminative model, and generates a set of candidate planes by sampling and clustering points from the image with Random Sample Consensus (RANSAC), using local normal estimates derived from Principal Component Analysis (PCA) to inform the planar models. These two models are incorporated into a two-layer Markov Random Field (MRF): an appearance- and disparity-based discriminative classifier at the mid-level, and a geometric model to segment the building pixels into facades at the high-level. By using object-specific stereo features, our discriminative classifier is able to achieve substantially higher accuracy than standard boosting or modeling with only appearance-based features. Furthermore, the results of our MRF classification indicate a strong improvement in accuracy for the binary building detection problem and the labeled planar surface models provide a good approximation to the ground truth planes.     

Data quality assessment: The Hybrid Approach

Various techniques have been proposed to enable organisations to assess the current quality level of their data. Unfortunately, organisations have many different requirements related to data quality (DQ) assessment. For example, some organisations may need to focus on ensuring regulations are met rather than reducing costs. Due to this, organisations may be forced to follow an assessment technique, which may not wholly fit their needs and current situation. Therefore, we propose and evaluate the Hybrid Approach to assessing DQ, which demonstrates how to dynamically configure an assessment technique as needed while leveraging the best practices from existing assessment techniques.     

Adaptive mechanism-based congestion control for networked systems

In order to assure the communication quality in network systems with heavy traffic and limited bandwidth, a new ATRED (adaptive thresholds random early detection) congestion control algorithm is proposed for the congestion avoidance and resource management of network systems. Different to the traditional AQM (active queue management) algorithms, the control parameters of ATRED are not configured statically, but dynamically adjusted by the adaptive mechanism. By integrating with the adaptive strategy, ATRED alleviates the tuning difficulty of RED (random early detection) and shows a better control on the queue management, and achieve a more robust performance than RED under varying network conditions. Furthermore, a dynamic transmission control protocol–AQM control system using ATRED controller is introduced for the systematic analysis. It is proved that the stability of the network system can be guaranteed when the adaptive mechanism is finely designed. Simulation studies show the proposed ATRED algorithm achieves a good performance in varying network environments, which is superior to the RED and Gentle-RED algorithm, and providing more reliable service under varying network conditions.     

A time-sequence-based fuzzy support vector machine adaptive filter for tremor cancelling for microsurgery

Hand tremors may cause some blemishes in precision and stability of a minimally invasive surgery (MIS). To track the tremor signals accurately, there are two main problems left to be settled. First, it is not practical to collect the sample data of tremor in large scale in practical applications. To deal with the hand tremors, a learning method based on small samples sizes and high dimensional input space is needed. Second, the hand tremors have time-varying characteristics. This fact is neglected by traditional learning methods, which could lead to imprecision and instability of a MIS. In this work, a time-sequence-based fuzzy support vector machine adaptive filter (TSF-SVMAF) for tremor cancelling is proposed. The proposed method is based on support vector machine and time series. It is suitable for solving the problem that the inputs are time-varying and the samples are small-scale. To cancel the time-varying hand tremors, different learning-weight-functions are designed for tremor signals with different frequencies. From the simulation results, compared with the existing methods such as back propagation (BP), weighted-frequency Fourier combiner (WFLC) and bandlimited multiple Fourier linear combiner (BMFLC), the proposed method has better performance when learning the time-varying hand tremors with small sample sizes.     

On the upstream inputs into the MODIS primary productivity products using biometric data from oil palm plantations

This study evaluated the influence of upstream inputs into the Moderate Resolution Imaging Spectroradiometer (MODIS) primary productivity products, termed the MOD17, at tropical oil palm plantations (Elaeis guineensis Jacq.). Evaluation of MOD17 using oil palm plantations as test sites is ideal because the plantations are cultivated on large areas which are comparable with the size of MODIS pixels. It is difficult to find test sites covered by other single species in a whole pixel. The upstream inputs studied included (1) MODIS land cover, (2) the National Centers for Environmental Prediction–Department of Energy (NCEP-DOE) Reanalysis 2 meteorological data set, (3) MODIS leaf area index/fraction of photosynthetically active radiation (LAI/fPAR), and (4) MODIS maximum light-use efficiency (maximum LUE). Oil palm biometric and local meteorological data were utilized as ground data. Furthermore, scaling up oil palm LAI and fPAR from plot scale to regional scale (Peninsular Malaysia) was done empirically by correlating oil palm LAI derived from the hemispherical photography technique with radiance information from the Disaster Monitoring Constellation 2 satellite (UK-DMC 2). The upscaled LAI/fPAR developed in this study was used to evaluate the MODIS LAI/fPAR. The results showed that the MODIS land-cover product has an overall accuracy of 78.8% when compared to the Peninsular Malaysia land-use map produced by the Department of Agriculture, Malaysia. Regarding the NCEP-DOE Reanalysis 2 data set, vapour pressure deficit (VPD) and photosynthetically active radiation (PAR) contain large uncertainties in our study area. However, MODIS LAI and fPAR were correlated relatively well with the upscaled LAI (R² = 0.50) and the upscaled fPAR (R² = 0.60), respectively. The constant values of maximum LUE for croplands and evergreen broadleaf forest ecosystems are lower than the maximum LUE of oil palm. The relative predictive error assessment showed that the MOD17 net primary productivity (NPP) overestimated oil palm NPP derived from biometric methods by 142–204%. We replaced the upstream inputs of MOD17 by the local inputs for estimating oil palm GPP and NPP in Peninsular Malaysia. This was done by (1) assigning maximum LUE for oil palm plantations as a constant at 1.68 g C m^?2 day^?1, (2) utilizing meteorological data from local meteorological stations, and (3) using the upscaled fPAR of oil palm plantations. The amount of oil palm GPP and NPP for Peninsular Malaysia in 2010 were estimated to be ~0.09 Pg C year^?1 (or equivalent to ~0.33 Pg CO₂ year^?1) and ~0.03 Pg C year^?1 (~0.11 Pg CO₂ year^?1), respectively, indicating that oil palm plantations in Peninsular Malaysia can play an important role in global carbon sequestration. In the future there is likely to be a demand for MODIS GPP and NPP products that are more accurate than those currently generated by MOD17. We recommend future developments of the MOD17 processing system to allow improvements in the upstream input parameters, in the manner described in this article, both for global processing and for the production of more accurate values for GPP and NPP at regional and local scales.     

Remote sensing data analysis for mapping active faults in the northwestern part of Kangra Valley,NW Himalaya,India

Aerospace data show morphological features indicative of two prominent active faults to the northwest of the Kangra valley, the meizoseismal zone of the 1905 Kangra earthquake (M 7.8). Topographical features indicative of long‐term uplift/deformation during the Holocene and cumulative slip along these faults reflect the manifestation of normal faulting. The south‐side‐up behaviour of these two faults is in contrast to the general north‐side‐up movement along the Main Boundary Thrust (MBT). The newly identified faults suggest that the fault scarps have developed because of large‐magnitude earthquakes in the past, preceding the known 1905 Kangra earthquake. The study also demonstrates that valuable geomorphological and structural inferences associated with active tectonics are possible using high‐resolution satellite data for the tectonically complex terrain of the Himalaya.