基于RDF4S的一种轻量语义Web服务组合

首先简要介绍语义Web服务资源描述框架(RDF4S),在此基础上提出语义Web服务包装机制,语义Web服务经包装后,分别通过组合接口和调用接口为组合语义Web服务的设计与调用提供支持.然后分别详细介绍组合语义Web服务的设计存储和调用执行:通过图形化的设计工具按照语义Web服务的3种基本逻辑关系设计组合结构图,然后将该图映射到组合结构信息表存储,组合语义Web服务执行时根据结构信息表生成语义Web服务代理对象和相应的语义消息,再根据语义消息传递机制调用Web服务实体.最后用一个实例展示组合语义Web服务执行时的消息传递,试验表明该方法有效.     

Twenty‐five years of the Information Systems Journal: A bibliometric and ontological overview

The Information Systems Journal (ISJ) published its first issue in 1991, and in 2015, the journal celebrated its 25th anniversary. This study presents an overview of the leading research trends in the papers that the journal has published during its first quarter of a century via a bibliometric and ontological analysis. From a bibliometric perspective, the analysis considers the publication and citation structure of the journal. The study then develops a graphical analysis of the bibliographic material by using visualization of similarities software that employs bibliographic coupling and cocitation analysis. The work produces an ontological framework of impact and analyses the journal papers to assess qualitatively ISJ's impact. The results indicate that the journal has grown significantly over time and is now recognized as one of the leading journals in information systems. Yet challenges remain if the journal is to meet its aims in impacting and setting the agenda for the development of the Information Systems field.     

A global optimization strategy for predicting alpha-helical protein tertiary structure

We present a global optimization strategy that incorporates predicted restraints in both a local optimization context and as directives for global optimization approaches, to predict protein tertiary structure for alpha-helical proteins. Specifically, neural networks are used to predict the secondary structure of a protein, restraints are defined as manifestations of the network with a predicted secondary structure and the secondary structure is formed using local minimizations on a protein energy surface, in the presence of the restraints. Those residues predicted to be coil, by the network, define a conformational sub-space that is subject to optimization using a global approach known as stochastic perturbation that has been found to be effective for Lennard-Jones clusters and homo-polypeptides. Our energy surface is an all-atom 'gas phase' molecular mechanics force field, that is combined with a new solvation energy function that penalizes hydrophobic group exposure. This energy function gives the crystal structure of four different alpha-helical proteins as the lowest energy structure relative to other conformations, with correct secondary structure but incorrect tertiary structure. We demonstrate this global optimization strategy by determining the tertiary structure of the A-chain of the alpha-helical protein, uteroglobin and of a four-helix bundle, DNA binding protein.     

有关建筑教育和理论的当代思索——菲利普·乌尔施布隆访谈

访谈中菲利普·乌尔施布隆首先讨论了当前历史性面临的危机,并得出"建筑理论已失去它的自主性"的观点.他认为当代理论已不存在中心化的大师理论,而是呈现出多元化的概念,恰如米克·巴尔的"微型理论"般运作.基于巴尔关于"概念旅行"的理论,他探讨了全球化语境下建筑教育的新机遇,最后由此出发分析中国与西方国家当代建筑教育之间的相互...     

Functions and Mechanisms of Pro-Lysyl Oxidase Processing in Cancers and Eye Pathologies with a Focus on Diabetic Retinopathy

Lysyl oxidases are multifunctional proteins derived from five lysyl oxidase paralogues (LOX) and lysyl oxidase-like 1 through lysyl oxidase-like 4 (LOXL1–LOXL4). All participate in the biosynthesis of and maturation of connective tissues by catalyzing the oxidative deamination of lysine residues in collagens and elastin, which ultimately results in the development of cross-links required to function. In addition, the five LOX genes have been linked to fibrosis and cancer when overexpressed, while tumor suppression by the propeptide derived from pro-LOX has been documented. Similarly, in diabetic retinopathy, LOX overexpression, activity, and elevated LOX propeptide have been documented. The proteolytic processing of pro-forms of the respective proteins is beginning to draw attention as the resultant peptides appear to exhibit their own biological activities. In this review we focus on the LOX paralogue, and what is known regarding its extracellular biosynthetic processing and the still incomplete knowledge regarding the activities and mechanisms of the released lysyl oxidase propeptide (LOX-PP). In addition, a summary of the roles of both LOX and LOX-PP in diabetic retinopathy, and brief mentions of the roles for LOX and closely related LOXL1 in glaucoma, and keratoconus, respectively, are included.     

Experimental investigation of a cook-off temperature in a hot barrel

The experimental investigations of the effect of contact time/temperature on initiating the cook-off using 7.62 mm calibre cartridge cases （CC） were conducted previously. These cartridges were filled with commercial off-the-shelf （COTS） double based （DB） propellant （Bulls Eye） and were loaded in a hot chamber. The thermal explosion temperature is of great significance to both weapon designers and safety inspectors as it provides the operational limit and safe operating temperature. For CC under test, it was found that the cook-off temperatures of this propellant were encountered with the heat transfer profile of the simulated gun barrel between 151.4 ℃ and 153.4 ℃, with a reaction occurring in less than 300 s after the round was chambered. Usefully, each experiment was found to be consistent and repeatable.     

Stress induced crystallization of hydrogenated amorphous silicon

Hydrogenated amorphous silicon films were grown on to thermally oxidized silicon wafers by Radio Frequency magnetron sputtering, and SiN_x and Al₂O₃ capping layers were used to control the residual thermal stress. After annealing, a comparison of the silicon films with and without capping layers indicates that tensile stress induced by the capping layer enhances the crystallinity of the annealed amorphous silicon film. The stress is due to the mismatch between the coefficients of thermal expansion for the capping layer and amorphous silicon film. These results highlight the potential of thermal stress as a means to alter the crystallization in thin film architectures and suggest that even larger effects can be obtained with suitable choices of capping layer chemistry.     

Fab-Union: A Collective Online to Offline Robotic Design Platform

Official architectural education in China remains very traditional and has yet to engage with the digital age. To counter this, Shanghai-based Fab-Union was set up in 2014 to establish a cross-disciplinary community – now over 10,000 strong – that is driving the emergence of digital crafts in the country. Here, its founder Philip Yuan and lead designer Hao Meng describe Fab-Union's online design platform, its offline collective design space, and its robotic factory that functions as an open research facility and fabrication workshop.     

Geothermal energy in Australia

Although Australia is not usually associated with geothermal energy, it possesses significant amounts of both conventional (wet) geothermal and hot dry rock (HDR) geothermal resources. The country's conventional geothermal resources are extensive, but are low temperature and are located in areas of low population density with the result that they are not used extensively for either electricity generation or for direct heating. Australia's HDR resources, on the other hand, represent a world-class resource but have not been used to date because the technology for converting HDR resources into electricity is not yet fully commercial. The effort being directed towards exploring economically useful HDR resources and in the development of technology to convert this energy resource into electricity could make HDR resources an important part of Australia's energy mix in the near future, but there are major barriers.