MDSM: Microarray database schema matching using the Hungarian method

Current microarray databases use different terminologies and structures and thereby limit the sharing of data and collating of results between laboratories. Consequently, an effective integrated microarray data model is required. One important process to develop such an integrated database is schema matching. In this paper, we propose an effective schema matching approach called MDSM, to syntactically and semantically map attributes of different microarray schemas. The contribution from this work will be used later to create microarray global schemas. Since microarray data is complex, we use microarray ontology to improve the measuring accuracy of the similarity between attributes. The similarity relations can be represented as weighted bipartite graphs. We determine the best schema matching by computing the optimal matching in a bipartite graph using the Hungarian optimisation method. Experimental results show that our schema matching approach is effective and flexible to use in different kinds of database models such as; database schema, XML schema, and web site map. Finally, a case study on an existing public microarray schema is carried out using the proposed method.     

Can the Shape of Nanoparticles Enable the Targeting to Cancer Cells over Healthy Cells?

Macropinocytosis is a consequence of oncogenic alterations of cancer cells while most healthy cells are non-macropinocytic. It is currently unclear whether macropinocytic cancer cells can be targeted rather than healthy cells, by adjusting the shape and size of nanoparticles. Herein, the endocytosis of two differently shaped nanoparticles; nanorods and nanospheres are compared in cancer and healthy cells. The cells are breast epithelial cancer cells (MCF7) and breast epithelial healthy cells (MCF10A) and pancreas cancer cells (PANC-1 cells) and non-tumourogenic patient-derived cancer-associated fibroblasts (CAFs). The endocytosis pathway is quantified by a combination of pair correlation microscopy and endocytosis inhibitors. MCF7 cells use clathrin-mediated endocytosis and macropinocytosis to take up the nanorods while MCF10A cells use predominantly clathrin-mediated endocytosis. Based on the comparison of endocytic behavior of cancer and healthy cells, MCF7 cells can be induced to take up more nanorods and suppress the metabolism and endocytosis of nanorods in MCF10A cells. The nanorods allow targeting to breast cancer MCF7 cells and pancreas cancer cells over the healthy cells. This study opens exciting possibilities for shape to target the cancer cells over healthy cells, by adjusting nanoparticle shape.     

Proud Americans and lucky Japanese: Cultural differences in appraisal and corresponding emotion.

Appraisal theories of emotion propose that the emotions people experience correspond to their appraisals of their situation. In other words, individual differences in emotional experiences reflect differing interpretations of the situation. We hypothesized that in similar situations, people in individualist and collectivist cultures experience different emotions because of culturally divergent causal attributions for success and failure (i.e., agency appraisals). In a test of this hypothesis, American and Japanese participants recalled a personal experience (Study 1) or imagined themselves to be in a situation (Study 2) in which they succeeded or failed, and then reported their agency appraisals and emotions. Supporting our hypothesis, cultural differences in emotions corresponded to differences in attributions. For example, in success situations, Americans reported stronger self-agency emotions (e.g., proud) than did Japanese, whereas Japanese reported a stronger situation-agency emotion (lucky). Also, cultural differences in attribution and emotion were largely explained by differences in self-enhancing motivation. When Japanese and Americans were induced to make the same attribution (Study 2), cultural differences in emotions became either nonsignificant or were markedly reduced. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Computational intelligence for microarray data and biomedical image analysis for the early diagnosis of breast cancer

The objective of this paper was to perform a comparative analysis of the computational intelligence algorithms to identify breast cancer in its early stages. Two types of data representations were considered: microarray based and medical imaging based. In contrast to previous researches, this research also considered the imbalanced nature of these data. It was observed that the SMO algorithm performed better for the majority of the test data, especially for microarray based data when accuracy was used as performance measure. Considering the imbalanced characteristic of the data, the Naive Bayes algorithm was seen to perform highly in terms of true positive rate (TPR). Regarding the influence of SMOTE, a well-known imbalanced data classification technique, it was observed that there was a notable performance improvement for J48, while the performance of SMO remained comparable for the majority of the datasets. Overall, the results indicated SMO as the most potential candidate for the microarray and image dataset considered in this research.     

Highlights for more complete sports video summarization

Summarization is an essential requirement for achieving a more compact and interesting representation of sports video contents. We propose a framework that integrates highlights into play segments and reveal why we should still retain breaks. Experimental results show that fast detections of whistle sounds, crowd excitement, and text boxes can complement existing techniques for play-breaks and highlights localization.     

Response biases in lineups and showups.

The showup, or presentation of a single suspect to an eyewitness, is widely believed to be a more biased and suggestive identification procedure than the lineup even though there has been no empirical work on this issue. Results suggest, however, that witnesses at a lineup are less likely to say "not there" than are witnesses at a showup. This tendency is seen in both live and photographic identification procedures, in both laboratory studies and real-world identifications. Showups in the lab resulted in no more mistaken identifications than lineups. Results also suggest that a showup is not equivalent to a poor lineup (i.e., a lineup with a functional size of 1). It is hypothesized that a showup leads to an absolute judgment, whereas a lineup leads to a relative judgment, and that the police pressures on witnesses are unlikely to be any greater for showup than for lineup identifications. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Quantitative determination of amino acid levels in neutral and glucosamine-containing carbohydrate polymers

OBJECTIVE: To determine whether local cardiac angiotensin converting enzyme (ACE) expression is upregulated during the development of hypoxia-induced right ventricular hypertrophy. METHODS: ACE activity was measured in membrane preparations from the right ventricle and left ventricle plus septum in normoxic rats and animals exposed to chronic hypoxia for 8 and 14 days. Local cardiac ACE expression was studied by immunohistochemistry using a monoclonal antibody to ACE (9B9). RESULTS: In the normal rat heart, ACE expression was confined to vascular endothelium, the valvular endocardium, and localized regions of parietal endocardium. We found that the development of pulmonary hypertension and right ventricular hypertrophy were associated with 2.6- and 3.4-fold increases in membrane-bound right ventricular ACE activity by 8 and 14 days of hypoxia, respectively. Right ventricular ACE activity was positively correlated with the degree of right ventricular hypertrophy (r = 0.83, P < 0.001). In contrast, left ventricular plus septal ACE activity was significantly reduced by approximately 40 and 60% by 8 and 14 days of hypoxia, respectively, compared to controls. In the right ventricle of chronically hypoxic rats, immunohistochemistry demonstrated increased ACE expression in areas of myocardial fibrosis. Interestingly, increased ACE expression was noted in the right ventricular epicardium in chronically hypoxic rats. In the free wall of the left ventricle there was a significant reduction in the number of myocardial capillaries which expressed ACE in chronically hypoxic rats. CONCLUSION: Chronic hypoxia has a differential effect on left and right ventricular ACE activity and that the sites of altered ACE expression are highly localized. We speculate that locally increased right ventricular ACE activity and expression may play a role in the pathogenesis of right ventricular hypertrophy secondary to hypoxic pulmonary hypertension.     

Amae in Japan and the United States: An exploration of a "culturally unique" emotion.

The experience of an emotion considered to be culturally unique (i.e., Japanese Amae) was tested in the United States, where there is no word to describe the concept. North American and Japanese participants read scenarios in which a friend made an inappropriate request (Amae), made no request, or made the request to another friend. Both American and Japanese participants felt more positive emotion and perceived the requester as feeling closer to them in the Amae condition than in the other two conditions. However, Americans felt more in control when asked for a favor than when not asked, a pattern that did not emerge among the Japanese. Cultural specificity of hypocognized emotions is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Juror comprehension and public policy: Perceived problems and proposed solutions.

Laypersons, the media, and many legal scholars tend to attribute problems in the jury system to the dispositions of individual jurors and to recommend reforms in jury selection procedures and relaxation of the unanimity rule. Social scientists view problems as a consequence of the structure of the jurors' task and recommend reforms in trial procedures. After years of apathy, the legal system has proposed, and in some jurisdictions implemented, a variety of reforms, most of which are based on the social science perspective that the problem is not due to bad jurors but to unnecessary procedural obstacles to high-quality decision making. These reforms are described in the final section of the article. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Valuing a wind farm construction: A contingent valuation study in Greece

Our analysis is based on data from a double-bounded dichotomous choice contingent valuation study implemented to elicit public attitudes towards renewable energy generation and their willingness to pay for the construction of a wind farm in the area of Messanagros in the island of Rhodes, Greece. Results indicate that there are significant positive values deriving from the proposed project. Respondents report a mean willingness to pay a premium in their bi-monthly electric bills of €8.86 for the sole purpose of the construction of the wind farm. The estimated economic benefits to the local population are weighed against the investment cost in a cost–benefit analysis to inform policy making and implications for EU energy policy are provided.