Overview of microneedle system: a third generation transdermal drug delivery approach

Transdermal drug delivery has given cardinal contribution to medical practices. First-generation transdermal delivery of small, lipophilic, low-dose drugs and second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in various clinical products provides added functionality. Third-generation delivery systems using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound targeting skin’s barrier layer of stratum corneum. Microneedles acquire pronounced intrigue in recent days. Currently, microneedles are advancing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. The review explains about the concept of transdermal drug microneedle system comprising of microreservoir, micropumps, flow sensors, types of microneedles. Various researches carried out on these components of microneedle system is elaborately discussed in this review.     

A performance evaluation framework of public health distribution network for essential medicines: lessons from the select Indian states

The present work has been carried out to develop a performance evaluation framework of distribution network design in public health with specific reference to essential medicines based on six different types of public health distribution networks (PHDNs) prevalent across six Indian states. We evaluated the performance of PHDNs on the criteria of cost and service and also on the sub-criteria of cost and service by following the analytic hierarchy process. We utilized the pairwise comparison method in determining the relative importance of criteria and sub-criteria by seeking responses from several experts and subsequently evaluated the PHDNs on all sub-criteria in a 7-point Likert scale by seeking views from the same experts. Finally, we developed the “cost–service matrix,” in which cost and service have been depicted in the horizontal and vertical axes, respectively. We demonstrated the performance of six PHDNs in this matrix in terms of cost and service by plotting scores obtained by them on cost and service, respectively. The findings of the study provide rich insights to the policy planners of public health.     

Early detection of heart diseases using a low-cost compact ECG sensor

Multimedia Tools and Applications - Heart disease patients are continuously increasing. The patients face the problem of a delayed diagnosis as the subjects do not undergo routine tests and consult...     

Direction prediction for avoiding occlusion in visual surveillance

Occurrence of occlusion while providing visual surveillance leads to anarchy as the track of the subject under motion may be lost. This often results into the failure of the surveillance system. The approach of predicting motion of moving subjects and hence the chances of their mutual occlusion gives an upper hand to surveillance system to take in-time necessary action towards mitigation of loss of track during dynamic occlusion. Direction of motion of a moving subject plays a major role while studying its motion. Direction along with the velocity of a subject in a 3D plane completely describes the motion of any subject. This article proposes a model‘-based approach for direction prediction of a moving subject in a 3D global plane as acquired in a 2D camera plane. The proposed approach uses the eight discrete directions of motion as proposed in and models different directions. The proposed direction prediction method is experimentally verified with six different classifiers, i.e. regression analysis, simple logistic regression, MLP, k-NN, SVM and Bays classifier over existing as well as self-acquired databases. The initial simulation results are motivating as the overall accuracies achieved through different classifiers are of the range of 87–94 \(\%\), which advocates the suitability of the said approach.     

FireFly: a cross-layer platform for real-time embedded wireless networks

We propose a cross-layer approach with tightly-coupled time synchronization for real-time support and predictable lifetime in battery-operated sensor networks. Our design spans a sensor hardware platform with hardware-based global time synchronization, a TDMA link layer protocol with collision-free multi-hop support and node scheduling algorithms for maximum concurrency and streaming. Our dual-radio sensor platform, FireFly, features an IEEE 802.15.4 transceiver and supports global time synchronization indoors by using an AM radio carrier-current method and an atomic clock receiver for outdoors. A TDMA-based link protocol, RT-Link, leverages the hardware for fixed and mobile nodes with a near-optimal and predictable node lifetime of over 2 years. It outperforms comparable sensor network link protocols such as B-MAC and S-MAC in terms of end-to-end latency and throughput and node lifetime across all duty cycle ratios. Operating over RT-Link is MAX, a scheduling framework which offers optimal transmission concurrency and bandwidth management for networks with regular structure. Through analysis and experiments we show that global time sync is a robust, economical and scalable alternative to in-band software-based techniques. To illustrate the capabilities and flexibility of our platform, we describe our experiences with two-way voice streaming over multiple hops. We have deployed a 42-node network with sub-100 μs synchronization accuracy in the NIOSH experimental coal mine for people-tracking and voice communication.

The concert queueing game: to wait or to be late

We introduce the concert (or cafeteria) queueing problem: A finite but large number of customers arrive into a queueing system that starts service at a specified opening time. Each customer is free to choose her arrival time (before or after opening time), and is interested in early service completion with minimal wait. These goals are captured by a cost function which is additive and linear in the waiting time and service completion time, with coefficients that may be class dependent. We consider a fluid model of this system, which is motivated as the fluid-scale limit of the stochastic system. In the fluid setting, we explicitly identify the unique Nash-equilibrium arrival profile for each class of customers. Our structural results imply that, in equilibrium, the arrival rate is increasing up until the closing time where all customers are served. Furthermore, the waiting queue is maximal at the opening time, and monotonically decreases thereafter. In the simple single class setting, we show that the price of anarchy (PoA, the efficiency loss relative to the socially optimal solution) is exactly two, while in the multi-class setting we develop tight upper and lower bounds on the PoA. In addition, we consider several mechanisms that may be used to reduce the PoA. The proposed model may explain queueing phenomena in diverse settings that involve a pre-assigned opening time.     

Majorisations for the eigenvectors of graph-adjacency matrices

We develop majorisation results that characterise changes in eigenvector components of a graph's adjacency matrix when its topology is changed. Specifically, for general (weighted, directed) graphs, we characterise changes in dominant eigenvector components for single- and multi-row incrementations. We also show that topology changes can be tailored to set ratios between the components of the dominant eigenvector. For more limited graph classes (specifically, undirected, and reversibly-structured ones), majorisations for components of the subdominant and other eigenvectors upon graph modifications are also obtained.     

On the sizing of a solar thermal electricity plant for multiple objectives using evolutionary optimization

Design, implementation and operation of solar thermal electricity plants are no more an academic task, rather they have become a necessity. In this paper, we work with power industries to formulate a multi-objective optimization model and attempt to solve the resulting problem using classical as well as evolutionary optimization techniques. On a set of four objectives having complex trade-offs, our proposed procedure first finds a set of trade-off solutions showing the entire range of optimal solutions. Thereafter, the evolutionary optimization procedure is combined with a multiple criterion decision making (MCDM) approach to focus on preferred regions of the trade-off frontier. Obtained solutions are compared with a classical generating method. Eventually, a decision-maker is involved in the process and a single preferred solution is obtained in a systematic manner. Starting with generating a wide spectrum of trade-off solutions to have a global understanding of feasible solutions, then concentrating on specific preferred regions for having a more detailed understanding of preferred solutions, and then zeroing on a single preferred solution with the help of a decision-maker demonstrates the use of multi-objective optimization and decision making methodologies in practice. As a by-product, useful properties among decision variables that are common to the obtained solutions are gathered as vital knowledge for the problem. The procedures used in this paper are ready to be used to other similar real-world problem solving tasks.     

Fuzzy Fruit Fly Optimized Node Quality-Based Clustering Algorithm for Network Load Balancing

Recently, the fundamental problem with Hybrid Mobile Ad-hoc Networks (H-MANETs) is to find a suitable and secure way of balancing the load through Internet gateways. Moreover, the selection of the gateway and overload of the network results in packet loss and Delay (DL). For optimal performance, it is important to load balance between different gateways. As a result, a stable load balancing procedure is implemented, which selects gateways based on Fuzzy Logic (FL) and increases the efficiency of the network. In this case, since gateways are selected based on the number of nodes, the Energy Consumption (EC) was high. This paper presents a novel Node Quality-based Clustering Algorithm (NQCA) based on Fuzzy-Genetic for Cluster Head and Gateway Selection (FGCHGS). This algorithm combines NQCA with the Improved Weighted Clustering Algorithm (IWCA). The NQCA algorithm divides the network into clusters based upon node priority, transmission range, and neighbour fidelity. In addition, the simulation results tend to evaluate the performance effectiveness of the FFFCHGS algorithm in terms of EC, packet loss rate (PLR), etc.     

An Ensemble Based Approach for Sentiment Classification in Asian Regional Language

In today’s digital world, millions of individuals are linked to one another via the Internet and social media. This opens up new avenues for information exchange with others. Sentiment analysis (SA) has gotten a lot of attention during the last decade. We analyse the challenges of Sentiment Analysis (SA) in one of the Asian regional languages known as Marathi in this study by providing a benchmark setup in which we first produced an annotated dataset composed of Marathi text acquired from microblogging websites such as Twitter. We also choose domain experts to manually annotate Marathi microblogging posts with positive, negative, and neutral polarity. In addition, to show the efficient use of the annotated dataset, an ensemble-based model for sentiment analysis was created. In contrast to others machine learning classifier, we achieved better performance in terms of accuracy for ensemble classifier with 10-fold cross-validation (cv), outcomes as 97.77%, f-score is 97.89%.