Modeling and simulation of an industrial‐scale parex process

The Parex unit for industrial‐scale purification of p‐xylene was studied through detailed simulation and the accuracy of the developed model tested against real industrial data. Starting from a comprehensive analysis of the construction and operation of the industrial unit, a simulation model was developed that incorporates the existing three major types of dead volumes: bed lines, which connect the beds to the rotary valve, circulation lines, which connect adjacent adsorbent chambers, and bed‐head dead volumes, which are located upstream of each bed due to the existence of internals. By gathering operation data and surveys in the pumparound line and in the extract stream, three case studies were defined and compared with simulation results. The model is capable of predicting the performance of the industrial unit. Further simulations were made and compared with plant data to assess the effect of adsorbent capacity loss on the long‐term performance of the unit. © 2015 American Institute of Chemical Engineers AIChE J, 61: 1345–1363, 2015     

The Anti-Inflammatory Effects of the Methanolic Extract and Fractions from Davilla elliptica St. Hil. (Dilleniaceae) on Bothrops jararaca Envenomation

Inflammation and haemorrhage are the main characteristics of tissue injury in botropic envenomation. Although some studies have shown that anti-venom prevents systemic reactions, it is not efficient in preventing tissue injury at the site of the bite. Therefore, this work was undertaken to investigate the anti-inflammatory effects of the methanolic extract and fractions from D. elliptica and to evaluate the role of matrix metalloproteinases (MMPs) in this process. Effects of the extract and fractions from D. elliptica were evaluated using a carrageenan-induced paw oedema model in rats, and leukocyte rolling was visualized by intravital. The quantification of MMPs activities (MMP-2 and MMP-9) extracted from the dermis of mice treated with extract and fractions alone or incubated with venom was determined by zymographic analyses. Our results show that intraperitoneal (i.p.) injection of fractions significantly reduced paw oedema after the carrageenan challenge. Treatment with the tannins fraction also resulted in considerable inhibition of the rolling of leukocytes and this fraction was able to decrease the activation of MMP-9. These results confirmed the anti-inflammatory activity of the methanolic extract and tannins fraction of D. elliptica and showed that the dermonecrosis properties of B. jararaca venom might be mediated through the inhibition of MMP-9 activity.     

Numerical approach to describe continuous and intermittent drying including the tempering period: Kinetics and spatial distribution of moisture

Continuous and intermittent drying experiments were performed with whole bananas, using hot air at 70°C. The intermittent drying experiments were performed with intermittency ratio equal to 1/2 and tempering times of 0.5, 1.0, and 2.0?h. The conditions imposed to the experiments permitted to investigate the influence of these tempering times on the processes. A one-dimensional numerical solution of the diffusion equation coupled with an optimizer was used to determine the process parameters for four experiments. To describe the processes, a model was proposed. Model includes shrinkage, variable effective mass diffusivity, and two values for convective mass transfer coefficient (within and outside the dryer), enabling to consider moisture loss during the tempering period. For all experiments, the simulation of the drying kinetics has resulted in good statistical indicators. Proposed model also made it possible to predict moisture distributions during the entire processes, including the migration of moisture from the central part to the peripheral region of the cross section of the bananas, during the tempering period. The results indicated that, for the same effective operation time and intermittency ratio, increasing the tempering time implied moderate decrease in the final average moisture content.     

Discrimination of Olive Oil by Cultivar,Geographical Origin and Quality Using Potentiometric Electronic Tongue Fingerprints

Legal regulations are set for protecting claims regarding olive oil geographical denomination. When meteorological or agroecological factors similarly affect different regions, the origin identification is a challenging task. This study demonstrated the use of a potentiometric electronic tongue coupled with linear discriminant analysis to discriminate the geographical origin of monovarietal Tunisian olive oil produced from local cv Chemlali (Kairouan, Sidi Bouzid or Sfax regions) and cv Sahli (Kairouan, Mahdia or Sousse regions). The potentiometric fingerprints of 12 or eight lipid sensors (for Chemlali and Sahli, respectively), selected using a simulated annealing meta-heuristic algorithm, allowed the correct prediction (repeated K-fold cross-validation) of the geographic production region with sensitivities of 92 ± 7% (Chemlali) and 97 ± 8% (Sahli). It was also confirmed the electronic tongue capability to classify Tunisian olive oil according to olive cultivar or quality grade. The results indicated the possible use of potentiometric fingerprints as a promising innovative strategy for olive oil analysis allowing assessing geographical origin, olive cultivar and quality grade, which are key factors determining olive oil price and consumers’ preference.     

Effect of Immersion Time in Osmosis and Ultrasound on Papaya Cell Structure during Dehydration

The effect of ultrasound-assisted osmotic dehydration applied at atmospheric pressure for different lengths of time on papaya tissue structure was evaluated. Ultrasound induced the loss of cellular adhesion, formation of large cell interspaces, and light rupture of the cell walls. The changes in the tissue structure caused by ultrasound application increased sugar loss, water loss, and effective water diffusivity. Ultrasound-assisted osmotic dehydration induced a gradual distortion in the shape of the cells, loss of cellular adhesion, and the formation of large channels caused by rupture of the cell walls. The changes caused by the application of osmotic dehydration resulted in high water loss and sugar gain.     

Semicontinuous Discharge of Non‐Newtonian Filter Cakes in Electrofiltration

A novel mode of operation for electrofiltration is presented. The newly developed operation procedure allows for cake removal without disassembling the chamber. Highly viscous filter cakes are discharged from the filtration chamber by inserting air which permits a rapid restart of the process. The cleaning time could be reduced from about 10 min to a few seconds. The semicontinuous operation is liable to full automation and allows for cake discharge and filtration in a short period of time. In successive cycles was proved that the process efficiency is maintained using the same membrane. A fully continuous system can be accomplished by assembling several units in parallel in a single filtration press.     

CO2/CH4 Separation by Adsorption using Nanoporous Metal organic Framework Copper‐Benzene‐1,3,5‐tricarboxylate Tablet

Equilibrium data for carbon dioxide and methane adsorption on nanoporous metal organic framework Cu‐BTC powder and tablets were measured in a magnetic suspension balance in the temperature range of 308–373 K and a pressure range of 0–7 bar and fitted with Langmuir model. The tablets adsorption loading is 0.63 mol kg^–1 for methane and 3.1 mol kg^–1 for carbon dioxide at 1 bar and 308 K, while these values are 0.77 and 3.9 mol kg^–1 for powder in the same conditions. Isosteric heats of adsorption were 22.8 and 15.0 kJ mol^–1 for carbon dioxide and methane, respectively, on both adsorbents, which indicates a strong adsorption of carbon dioxide. Also, single and binary breakthrough curves were measured in the same temperature range and atmospheric pressure by using Cu‐BTC tablets as adsorbent. A complete model was used in the simulation of breakthrough curves and good agreement was observed with experimental data.     

Synthesis and Evaluation of Water‐Soluble Prodrugs of Ursodeoxycholic Acid (UDCA), an Anti‐apoptotic Bile Acid

Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti‐apoptotic activity in both in vitro and in vivo models. However, its utility is hampered by limited aqueous solubility. As such, water‐soluble prodrugs of UDCA could have an advantage over the parent bile acid in indications where intravenous administration might be preferable, such as decreasing damage from stroke or acute kidney injury. Five phosphate prodrugs were synthesized, including one incorporating a novel phosphoryloxymethyl carboxylate (POMC) moiety. These prodrugs were highly water‐soluble, but showed significant differences in chemical stability, with oxymethylphosphate prodrugs being the most unstable. In a series of NMR experiments, the POMC prodrug was bioactivated to UDCA by alkaline phosphatase (AP) faster than a prodrug containing a phosphate directly attached to the alcohol at the 3‐position of UDCA. Both of these prodrugs showed significant anti‐apoptotic activity in a series of in vitro assays, although the POMC prodrug required the addition of AP for activity, while the other compound was active without exogenous AP.