Investigations of ferritic/martensitic super heat resistant 11‐12 %Cr steels for 650 °C power plants

The investigations of advanced ferritic/martensitic 11–12 %Cr steels for 650 °C power plant components focus on the improvement of high‐temperature creep properties with respect to chemical composition. The claim of the DFG research work was the development of new heat‐resistant 12 %Cr ferritic‐martensitic steels with sufficient creep and oxidation resistance for a 650 °C application by using basic principles and concepts of physical metallurgy on the basis of the state of art and to overcome the usual trial and error industrial alloy development. Efforts are focussed on a 100,000h creep strength of 100MPa at 650 °C in combination with a sufficient corrosion resistance by a Cr content of 12 % with contents 4‐5 %W, 3.4‐5,5 %Co, V, B and 1 %Cu as well as the choice of Ta or Ti instead of Nb. The results demonstrate that the aim is not to realize with the used alloying concept. In the long term range all 12 %Cr melts have a lower creep rupture strength than the advanced 9 %Cr piping steel P92. A high creep strength could be reached with a 0.06 % Ta alloyed 11 %Cr melt, which is in addition alloyed with a higher C and B content and as well as with lower W and Co portions. The results indicate in accordance with the finding of other steel researcher that a lower Cr content allows more effectiveness for the alloying partners respectively for the generation of more stable precipitates.     

Fabrication of collimating grids for an x-ray solar telescope using LIGA methods

 We are fabricating sub-collimating X-ray grids that are to be used in an orbiting solar X-ray telescope. The telescope optics consist of twelve rotating pairs of high aspect ratio grids. The pitch for the grids ranges from 34 μm to 317 μm. The grid thickness-to-grid-slit ratio must be approximately 50:1, resulting in grid thicknesses of 1 to 10 millimeters. We are implementing a design in which a 34 μm pitch, free-standing PMMA grid is fabricated with 20 μm wide slits through a 800 μm thickness. After exposure and developing, metal is electrodeposited into the slits in the PMMA grid and the PMMA is left in place to hold the individual metal pieces. For optimum imaging performance, the root-mean-square pitch of the two grids of each pair must match to within 1 part in 10000 and simultaneous exposures of stacked sheets of PMMA have insured that this requirement is met. Received: 30 October 1995 / Accepted: 25 January 1996     

Influence of Powder Morphology and Chemical Composition on Metallic Foams produced by SlipReactionFoamSintering (SRFS)‐ Process

The SlipReactionFoamSintering (SRFS)‐ process is a metallurgical method to produce open‐cell metallic foams of iron based materials, steels and nickel based materials. In this process several chemical reactions take place. Through the most influential parameter, the morphology of the metallic powder, different properties of the foam can be adjusted, such as the viscosity of the slip, the cell structure and the mechanical properties. Several examples are presented in this paper. Moreover, the thermal conductivity of three foams is measured with the transient‐heat‐source‐technique.     

Enhanced surface-excitonic emission in ZnO/Al(2)O(3) core-shell nanowires

We report the influence of an Al(2)O(3) shell on the photoluminescence emission of ZnO nanowires. At room temperature, the spectrum of the core-shell nanowires shows a strong reduction of the relative intensity of the green defect emission with respect to the near-band-edge emission. At 5?K an increase of the relative intensity of the surface exciton band with respect to the donor-bound exciton emission is observed. Annealing the core-shell nanowires at 500?°C does not increase the green defect luminescence at 5?K. We propose a model explaining the spectral changes.     

The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism

Dysregulated energy metabolism is a major contributor to a multitude of pathologies, including obesity and diabetes. Understanding the regulation of metabolic homeostasis is of utmost importance for the identification of therapeutic targets for the treatment of metabolically driven diseases. We previously identified the deubiquitinase OTUB1 as substrate for the cellular oxygen sensor factor-inhibiting HIF (FIH) with regulatory effects on cellular energy metabolism, but the physiological relevance of OTUB1 is unclear. Here, we report that the induced global deletion of OTUB1 in adult mice (Otub1 iKO) elevated energy expenditure, reduced age-dependent body weight gain, facilitated blood glucose clearance and lowered basal plasma insulin levels. The respiratory exchange ratio was maintained, indicating an unaltered nutrient oxidation. In addition, Otub1 deletion in cells enhanced AKT activity, leading to a larger cell size, higher ATP levels and reduced AMPK phosphorylation. AKT is an integral part of insulin-mediated signaling and Otub1 iKO mice presented with increased AKT phosphorylation following acute insulin administration combined with insulin hypersensitivity. We conclude that OTUB1 is an important regulator of metabolic homeostasis.     

The Chromatin Architectural Protein CTCF Is Critical for Cell Survival upon Irradiation-Induced DNA Damage

CTCF is a nuclear protein initially discovered for its role in enhancer-promoter insulation. It has been shown to play a role in genome architecture and in fact, its DNA binding sites are enriched at the borders of chromatin domains. Recently, we showed that depletion of CTCF impairs the DNA damage response to ionizing radiation. To investigate the relationship between chromatin domains and DNA damage repair, we present here clonogenic survival assays in different cell lines upon CTCF knockdown and ionizing irradiation. The application of a wide range of ionizing irradiation doses (0–10 Gy) allowed us to investigate the survival response through a biophysical model that accounts for the double-strand breaks’ probability distribution onto chromatin domains. We demonstrate that the radiosensitivity of different cell lines is increased upon lowering the amount of the architectural protein. Our model shows that the deficiency in the DNA repair ability is related to the changes in the size of chromatin domains that occur when different amounts of CTCF are present in the nucleus.