Vortex matter in superconductor/ferromagnet hybrids

Vortex pinning in type-II superconducting films can be effectively controlled by combining these films with different ferromagnetic nanostructures. In this article an overview is presented of different types of ferromagnetic pinning centers. The investigated hybrid structures consist of Pb films that are deposited on top of arrays of ferromagnetic dots with in-plane magnetization (IMP) or out-of-plane magnetization (OPM), ferromagnetic films with IPM or OPM that contain arrays of submicron holes (antidots), or continuous films with OPM and a magnetic domain structure. Interesting effects such as field-polarity dependent vortex pinning and the dependence of the pinning strength on the domain structure of the ferromagnet are observed. Our experiments demonstrate that vortex pinning in superconductors is strongly influenced by the magnetic properties of the different ferromagnetic pinning centers.     

Measuring the sensitivity of microwave components to bias variations

This paper presents a method to measure the sensitivity of microwave components to memory effects caused by the dc biasing circuit. This allows us to determine the required (impedance) properties of the dc biasing circuit to reduce slow dynamics under a certain level. The proposed measurement technique is based on the nonlinear vectorial network analyzer, which allows us to measure not only the absolute magnitude but also the absolute phase relations between the waves. Superimposing a multisine excitation signal on the dc bias allows us to measure the slow dynamics caused by the dc biasing circuit as a function of frequency and input power. Furthermore, it is verified whether or not the measured phenomena depend on the type of excitation signal.     

Evaluation of a multimode fiber optic low coherence interferometer for path length resolved Doppler measurements of diffuse light

The performance of a graded index multimode fiber optic low coherence Mach-Zehnder interferometer with phase modulation is analyzed. Investigated aspects were its ability to measure path length distributions and to perform path length resolved Doppler measurements of multiple scattered photons in a turbid suspension of particles undergoing Brownian and translational motion. The path length resolution of this instrument is compared with a system using single mode fibers for illumination and detection. The optical path lengths are determined from the zero order moment of the phase modulation peak in the power spectrum. The weighted first moment, which is equal to the average Doppler shift, shows a linear response for different mean flow velocities within the physiological range.     

Model-based quantification of EELS spectra: Including the fine structure

An extension to model-based electron energy loss spectroscopy (EELS) quantification is reported to improve the possibility of modelling fine structure changes in electron energy loss spectra. An equalisation function is used in the energy loss near edge structure (ELNES) region to model the differences between a single atom differential cross section and the cross section for an atom in a crystal. The equalisation function can be shown to approximate the relative density of unoccupied states for the given excitation edge. On a set of 200 experimental h-BN spectra, this technique leads to statistically acceptable models resulting into unbiased estimates of relative concentrations and making the estimated precisions come very close to the Cramér-Rao lower bound (CRLB). The method greatly expands the useability of model-based EELS quantification to spectra with pronounced fine structure. Another benefit of this model is that one also gets an estimate of the unoccupied density of states for a given excitation edge, without having to do background removal and deconvolution, making the outcome intrinsically more reliable and less noisy.     

Differential automatic zero-adjusting amplifier

A method is described for building a low-voltage-drift differential dc amplifier featuring automatic zero adjustment, a high input impedance, and a bandwidth of 10 kHz. This is achieved by an asymmetric two-step process between the input signal and ground. Bandwidth can be extended by the use of a second amplifier during the ground-sampling time. The amplifier can be made with standard electronic components. A major advantage of this method is that an existing amplifier can easily be converted into a low-voltage-drift amplifier by adding the essential elements of the described automatic zero-adjusting amplifier to its input stage. To illustrate the method a practical example is constructed featuring a drift of 0.2 microV/ degrees C.     

ANSIM: an anesthesia simulator for the IBM PC

Simulations based on physiologic modeling have been used for over twenty years to clarify the pharmacokinetics of inhaled anesthetics. We describe ANSIM, an anesthesia simulator for the IBM PC. ANSIM uses established modeling techniques to create a life-like anesthesia simulator. ANSIM is useful as an educational tool for demonstrating classic concepts of uptake and distribution of inhaled anesthetics.     

Genetic Dissection of Light-Regulated Adventitious Root Induction in Arabidopsis thaliana Hypocotyls

Photomorphogenic responses of etiolated seedlings include the inhibition of hypocotyl elongation and opening of the apical hook. In addition, dark-grown seedlings respond to light by the formation of adventitious roots (AR) on the hypocotyl. How light signaling controls adventitious rooting is less well understood. Hereto, we analyzed adventitious rooting under different light conditions in wild type and photomorphogenesis mutants in Arabidopsis thaliana. Etiolation was not essential for AR formation but raised the competence to form AR under white and blue light. The blue light receptors CRY1 and PHOT1/PHOT2 are key elements contributing to the induction of AR formation in response to light. Furthermore, etiolation-controlled competence for AR formation depended on the COP9 signalosome, E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC (COP1), the COP1 interacting SUPPRESSOR OF PHYA-105 (SPA) kinase family members (SPA1,2 and 3) and Phytochrome-Interacting Factors (PIF). In contrast, ELONGATED HYPOCOTYL5 (HY5), suppressed AR formation. These findings provide a genetic framework that explains the high and low AR competence of Arabidopsis thaliana hypocotyls that were treated with dark, and light, respectively. We propose that light-induced auxin signal dissipation generates a transient auxin maximum that explains AR induction by a dark to light switch.     

Circulating Monocyte Subsets and Transcatheter Aortic Valve Replacement

Transcatheter aortic valve replacement (TAVR), as an alternative to open heart surgery, has revolutionized the treatment of severe aortic valve stenosis (AVS), the most common valvular disorder in the elderly. AVS is now considered a form of atherosclerosis and, like the latter, partly of inflammatory origin. Patients with high-grade AVS have a highly disturbed blood flow associated with high levels of shear stress. The immediate reopening of the valve during TAVR leads to a sudden restoration of a normal blood flow hemodynamic. Despite its good prognosis for patients, TAVR remains associated with bleeding or thrombotic postprocedural complications, involving mechanisms that are still poorly understood. Many studies report the close link between blood coagulation and inflammation, termed thromboinflammation, including monocytes as a major actor. The TAVR procedure represents a unique opportunity to study the influence of shear stress on human monocytes, key mediators of inflammation and hemostasis processes. The purpose of this study was to conduct a review of the literature to provide a comprehensive overview of the impact of TAVR on monocyte phenotype and subset repartition and the association of these parameters with the clinical outcomes of patients with severe AVS who underwent TAVR.     

Characterization of the Basal and mTOR-Dependent Acute Pulmonary and Systemic Immune Response in a Murine Model of Combined Burn and Inhalation Injury

Severe burn injury leads to a cascade of local and systemic immune responses that trigger an extreme state of immune dysfunction, leaving the patient highly susceptible to acute and chronic infection. When combined with inhalation injury, burn patients have higher mortality and a greater chance of developing secondary respiratory complications including infection. No animal model of combined burn and inhalation injury (B+I) exists that accurately mirrors the human clinical picture, nor are there any effective immunotherapies or predictive models of the risk of immune dysfunction. Our earlier work showed that the mechanistic/mammalian target of rapamycin (mTOR) pathway is activated early after burn injury, and its chemical blockade at injury reduced subsequent chronic bacterial susceptibility. It is unclear if mTOR plays a role in the exacerbated immune dysfunction seen after B+I injury. We aimed to: (1) characterize a novel murine model of B+I injury, and (2) investigate the role of mTOR in the immune response after B+I injury. Pulmonary and systemic immune responses to B+I were characterized in the absence or presence of mTOR inhibition at the time of injury. Data describe a murine model of B+I with inhalation-specific immune phenotypes and implicate mTOR in the acute immune dysfunction observed.