Methotrexate therapy in rheumatoid arthritis: a life table review of 587 patients treated in community practice

To determine whether methotrexate (MTX) maintains its effectiveness in rheumatoid arthritis (RA) in the setting of community based private rheumatology practice we used life table analysis to review the combined experience of a group of these practices. Of 587 patients with RA who started to take MTX, total termination rate at 70 months was 24.4% with most terminations prompted by drug toxicity. Older age (greater than 65 years) was associated with higher rates of toxicity. Treatment termination rates varied substantially between rheumatologists. We conclude that MTX therapy for RA is well tolerated and maintains effectiveness for at least 70 months.     

聚丙烯共混表面改性剂的研究

由不同链长的甲基丙烯酸长链醇酯。少量改性剂与聚丙烯共混，能大幅增加聚丙烯表面润湿性与粘接性，而拉伸强度与熔点却变化不大。通过ＥＳＣＡ与接触角分析，发现极性基团大表面富集，添加不同改性剂使材料表面富集的极性基浓度与粘接强度产生差异。     

国产CN—31催化剂与ICI65—2催化剂工业应用的比较

国产轻油预转化催化剂与进口催化剂相比,具有性能相当、价格低廉、供应方便等优势。国产预转化催化剂需在较高的液空速、温度较低的条件下实现烃类转化反应,生成含甲烷60%以上的富气。采用国产催化剂能明显反映性能价格比。文章对两种催化剂进行了工业应用比较和分析。     

章江水闸安全论证

结合江西赣州章江水闸安全鉴定工作,阐明了水闸安全鉴定基本内容和方法,并参照有关规范和标准作出了安全分析评价.     

尼龙1010的流变性能研究

用XLY-Ⅱ重型毛细管流变仪研究了尼龙1010的流变特性。实验结果表明,尼龙1010为假塑性流体;在210～250℃范围内,其非牛顿指数π为0.63～0.71;恒γw＇下的粘流活化能随γw＇的增大而减小。     

Effects of fibinolysis on neurite growth from dorsal root ganglia cultured in two- and three-dimensional fibrin gels

The mechanism of neurite penetration of three-dimensional fibrin matrices was investigated by culturing embryonic chick dorsal root ganglia (DRGs) within fibrin gels, upon fibrin gels, and upon laminin. The length of neurites within three-dimensional matrices of fibrin was decreased in a concentration-dependent manner by agents that inhibited plasmin, e.g. aprotinin, or that inhibited plasminogen activation, e.g., epsilon-aminocaproic acid (EACA), or plasminogen antiserum. In contrast, such agents increased the length of neurites growing out from DRGs cultured upon two-dimensional substrates of fibrin and had no effect on the length of neurites growing out from DRGs cultured upon laminin. Visualization of neurites within three-dimensional fibrin matrices demonstrated that the distance between fibrin strands was much smaller than the diameter of neurites. All these data were consistent with the hypothesis that fibrinolysis localized to the region of the neurite tip is an important mechanism for neurite penetration of a physical barrier of fibrin strands arranged in a three-dimensional matrix.     

室温脉冲螺旋Wiggler磁体和大电流脉冲电源的研究

本文研究了适用于自由电子激光的室温脉冲螺旋Ｗｉｇｇｌｅｒ磁体，对其设计构思、磁场特性和设计参数进行了分析和计算．作者在文中还研究并设计了螺旋Ｗｉｇｇｌｅｒ磁体的大电流宽脉冲供电电源；分析了脉冲电流的时间特性对产生自由电子激光的影响程度．     

化工重大技术装备工作"十五"的成绩与"十一五"的任务

重大技术装备的制造水平是一个国家综合实力的直接体现,因此从上个世纪八十年代初开始,历届国务院领导人均兼任国家重大技术装备领导小组组长,通过推进重大技术装备的发展,促进     

舰船导航信号发生器虚拟化设计

介绍了基于PC总线的便携式舰船导航信号发生器虚拟化设计，着重叙述该仪器硬件设计、基于虚拟仪器开发平台LabWindows／CVI的软件设计。     

基于ISO质量体系认证在线计量数据智能统计和查询

ISO质量体系认证标准要求对计量数据进行计算和评价。公司的信息管理系统可以自动计算统计参数，并可以方便的进行分析和查询，提高企业工作效率，改善产品质量。论文为国家自然科学基金“现代制造质量控制、溯源中若干理论问题与技术基础的研究”(项目号：59735120)中的一部分。