Effect of Penetration Enhancers on Transdermal Delivery of Timolol Maleate

In vitro skin permeation of Timolol maleate through human cadaver skin was studied using Franz diffusion cell. The results indicate that the drug penetrates poorly through human cadaver skin. However, skin penetration enhancers such as dimethyl sulfoxide (DMSO), oleic acid (OA) and lauryl chloride (LC) enhanced the permeability of Timolol maleate (TM) through human cadaver skin. The permeation enhancement of drug was maximum by lauryl chloride amongst the three enhancers. Moreover, lauryl chloride increases the permeation of drug through skin with increase in the time of application and concentration on skin. The change in lag time was also observed.     

Bright red electroluminescence in diffused porous siliconp-n junction

We report the first operation of light emittingp-n junction diode in porous silicon fabricated by diffusion.     

Asymmetrical pulse-width-modulated resonant DC/DC convertertopologies

This paper presents asymmetrical pulse-width-modulated (APWM) DC/DC resonant converter topologies that exhibit near-zero switching losses while operating at constant and very high frequencies. The converters include a bridged chopper to convert the DC input voltage to a high-frequency unidirectional AC voltage, which in turn is fed to a high-frequency transformer through a resonant circuit. The bridged chopper has two switches that alternately conduct. The duty cycles of the conduction of the switches are complementary with one another and are varied to control the output voltage. Three resonant circuit configurations suitable for this type of control are presented. Frequency domain analysis of the converter is given, and performance characteristics are presented. Experimental results for a 48-5 V, 30 W converter show an efficiency of 88% at a constant operating frequency of 1 MHz     

Evaluation of solar fraction (Fn) for quonset type empty greenhouse: an experimental validation

In this study, the experiments were conducted from December 2000 to November 2001 to evaluate solar fraction (F_n) for quonset type empty greenhouse. Solar radiation was measured at different points inside and outside the greenhouse weekly once. The model based on Auto-CAD 2000 has been used for a given solar altitude and azimuth angles. Calculations have also been carried out for a typical day of each month of the year. It is observed that the solar fraction obtained by using Auto-CAD 2000 are very close to the value determined by using experimental observations and its value is more during winter months. Copyright © 2002 John Wiley & Sons, Ltd.     

Epidemiologic aspects of gallbladder cancer: a case-control study of the SEARCH Program of the International Agency for Research on Cancer

BACKGROUND: There are few previous epidemiologic studies of gallbladder cancer, a rare but nearly always lethal gastrointestinal cancer with a demonstrated greater frequency in adult women and older subjects of both sexes, and also in the members of populations throughout central and eastern Europe and certain racial groups such as native American Indians. Unfortunately, the prospects for the prevention of this form of cancer are poor. PURPOSE: Our purpose in conducting this study was to investigate possible new risk factors for gallbladder cancer and to strengthen our understanding of established causal agents that may be involved in this disease. METHODS: A large, collaborative, multicenter, case-control study of cancer of the gallbladder was conducted in five centers located in Australia (Adelaide), Canada (Montreal and Toronto), The Netherlands (Utrecht), and Poland (Opole) from January 1983 through July 1988. Case subjects with gallbladder cancer were accrued by the centers from hospital pathology records and from reports to regional cancer registries. Cancer diagnosis was confirmed by either biopsy, cholecystectomy, or at the time of autopsy. Control subjects were randomly assigned at each center from the population. The pooled analysis included 196 case subjects and 1515 control subjects (who did not report previous cholecystectomy). Ninety-eight percent of the subjects were white. Personal interviews of case subjects, control subjects, and surrogates (spouse or next of kin) were conducted by trained personnel. RESULTS: After adjusting for potential confounding factors (age, sex, center, type of interview, years of schooling, alcohol intake, and lifetime cigarette smoking), a history of gallbladder symptoms requiring medical attention (e.g., reduced bile secretion from the gallbladder into the small intestine due to obstructions of the common bile or cystic ducts) was the major risk factor associated with this form of cancer (odds ratio [OR] = 4.4; 95% confidence interval [CI] = 2.6-7.5). This association was present even in subjects who had their first gallbladder examination because of symptoms present more than 20 years earlier (OR = 6.2; 95% CI = 2.8-13.4). Other variables associated with gallbladder cancer risk included an elevated body mass index, high total energy intake, high carbohydrate intake (after adjustment for total energy intake), and chronic diarrhea. All of these risk factors have been previously associated with gallstone disease. CONCLUSIONS: These findings are consistent with a major role of gallstones, or risk factors for gallstones, in the cause of gallbladder cancer. Additional information on whether or not screening high-risk subjects for gallstones or gallbladder cancer is needed.     

An APWM resonant inverter topology for high frequency AC power distribution systems

In this paper, an asymmetrical pulse-width-modulated (APWM) resonant inverter topology is presented for high frequency AC power distribution systems. The inverter system is comprised of simple power and control circuitry. The detailed analysis shows that the proposed inverter has very low total harmonic distortion, near-zero switching losses, and fast transient response. A design procedure is illustrated as well. Simulation and experimental results are presented to prove the performance of the proposed inverter.     

Generalization and specialization strategies for learning r.e. languages

Overgeneralization is a major issue in the identification of grammars for formal languages from positive data. Different formulations of generalization and specialization strategies have been proposed to address this problem, and recently there has been a flurry of activity investigating such strategies in the context of indexed families of recursive languages. The present paper studies the power of these strategies to learn recursively enumerable languages from positive data. In particular, the power of strong-monotonic, monotonic, and weak-monotonic (together with their dual notions modeling specialization) strategies are investigated for identification of r.e. languages. These investigations turn out to be different from the previous investigations on learning indexed families of recursive languages and at times require new proof techniques. A complete picture is provided for the relative power of each of the strategies considered. An interesting consequence is that the power of weak-monotonic strategies is equivalent to that of conservative strategies. This result parallels the scenario for indexed classes of recursive languages. It is also shown that any identifiable collection of r.e. languages can also be identified by a strategy that exhibits the dual of weak-monotonic property. An immediate consequence of the proof of this result is that if attention is restricted to infinite r.e. languages, then conservative strategies can identify every identifiable collection. This revised version was published online in June 2006 with corrections to the Cover Date.     

Resource-requirements planning in flexible manufacturing systems

In this paper, we address the problem of planning the requirements of some of the important resources in flexible manufacturing systems. Specifically, we model the problem of estimating the required numbers and types of machines and tools in the context of a cellular layout. A two-stage procedure is developed which first forms the part families, using the complete-linkage clustering method based on a new similarity index defined in terms of the tooling requirements, and then subsequently estimates the resource requirements to manufacture the part families using an integer programming model. Several variations of the model are discussed and a numerical example is given.     

Lack of morphine and enkephalin tolerance in 129/SvEv mice: evidence for a NMDA receptor defect

Pregnancies in outbred mammals may be regarded as successfully developed homografts. One of the hypotheses that attempts to answer the enigma of why the fetus is not rejected (fetal-maternal relationships are based on reciprocal expressions of foreign transplantation antigens) claims for the existence of possible evolutionary links between invertebrate allorecognition and mammalian implantation, based on some cellular similarities. This essay further discusses the possible evolutionary perspectives between vertebrates and invertebrates alloimmunities from a different viewpoint. We discuss similarities between natural transplantation in colonial marine invertebrates, which are followed by chimerism and a state of tolerance, and two natural transplantation events in the mammalian systems which both have records for prolonged chimerism and tolerance: the phenomenon of dizygotic twin fusions and the situation of fetal cells implantation. Earlier comparative evolutionary perspectives are revisited.