In a recent report, the Institute of Medicine has stressed the need for dynamic mitigation strategies for pandemic influenza. In response to the need, we have developed a simulation-based optimization methodology for generating dynamic predictive mitigation strategies for pandemic outbreaks affecting several regions. Our methodology can accommodate varying virus and population dynamics. It progressively allocates a limited budget to procure vaccines and antivirals, capacities for their administration, and resources required to enforce social distancing. The methodology uses measures of morbidity, mortality, and social distancing, which are translated into the costs of lost productivity and medical services. The simulation model was calibrated using historic pandemic data. We illustrate the use of our methodology on a mock outbreak involving over four million people residing in four major population centers in Florida, USA. A sensitivity analysis is presented to estimate the impact of changes in the budget availability and variability of some of the critical parameters of mitigation strategies. The methodology is intended to assist public health policy makers. 相似文献
The aim of this paper was to analyse the spatial and temporal patterns and drivers of water quality in a large arid/semi-arid river system (River Murray, Australia) using a long term (1978???2015) dataset collected from 24 monitoring sites. The water quality is highly variable, but on average electrical conductivity (EC), pH, turbidity, dissolved and total nutrient, colour and chlorophyll a levels increase with distance downstream from the headwaters to the lower reaches. This is a function of the natural accumulation of dissolved and particulate components and intermittent, mostly diffuse source, pollutant inputs. The Darling tributary inflow increases turbidity, total phosphorus and pH in the main River Murray channel. Based on long-term trend analysis at four representative sites, EC, nutrients and colour showed declining trends on average at most sites except in the headwaters. Increased flow increases concentrations of most quality parameters, although at very high flows decreases in pH, EC, turbidity and oxidized nitrogen were apparent at many sites. The extreme “Millennium” drought (2002???2009) period resulted in lowered concentrations of many water quality parameters, indicating retention in the landscape. In the post-drought flooding (2010???2012) period a large amount of organic material was mobilised, resulting in much higher peak colour concentrations than when mid-range flooding was more frequent. It is critical that this monitoring program is continued as a Basin-wide water management plan is implemented.
A cost-effective and simple method is proposed wherein a Schottky ion sensitive field effect transistor (Schottky ISFET)-based sensor is characterised as metal oxide semiconductor and enzyme field effect transistor (ENFET). This technique involves deposition of mercury (Hg) as gate material over the sensing layer mitigating the complexity of fabrication process, thereby eliminating the need of refabricating an identical device. A Schottky-based ISFET simplifies the fabrication process as the requisite for doping of source and drain regions becomes redundant. Steps involved in lithography process for fabricating metal oxide semiconductor field effect transistor (MOSFET) are reduced with the use of liquid metal Hg as gate over layer. Such a device can be transformed back to an ISFET without any additional etching process. Furthermore, the same ISFET device can be utilised as an ENFET when the former is used in conjunction with a biological element. In this work, a Schottky-based ISFET has been characterised as Hg-MOSFET and as cytochrome P450-ENFET. Multiple tests on the device exhibit that the same ISFET sensor can be used both as a MOSFET and an ENFET with good repeatability and versatility without losing its sensitivity. 相似文献
A non-vacuum method for preparation of ZnO films via thermal oxidation of ZnS films deposited by thin layer thermolysis is described. Transmission electron microscopic studies reveals that the films are polycrystalline with preferentially oriented along (100) direction and grain size of 5-10 nm. The films have about 95% transmission in the visible-near infrared (VIS-NIR) region and an energy band gap of 3.22 eV. 相似文献
Titanium alloys are being increasingly employed in engineering and bio-medical applications, but their manufacturability via the cutting and grinding process is always a problem, which needs to be overcome. Inherent characteristics of Ti–6Al–4V alloy promote rapid tool wear, which needs to be curbed in order to attain high efficiency in metal cutting. Conventional or low-pressure cooling method fail to effectively conduct away the heat generated in the cutting zone, which is responsible for short tool life. High-pressure coolant jets were directed into the tool–chip interface to sufficiently penetrate and change the thermal, frictional and mechanical conditions in the cutting zone. High-pressure cooling using neat oil and water-soluble oil was undertaken and its effects on machining evaluation parameters such as chip form, chip breakability, cutting forces, coefficient of friction, contact length, tool life and surface finish of the finished workpiece were evaluated in comparison with those from the conventional cooling method. The results show that significant improvement in tool life and other evaluation parameters could be achieved utilising moderate range of coolant pressure. 相似文献
The tensile and fracture toughness behaviour of Ti-10V-4.5Fe-3Al alloy in the beta solution treated condition was investigated
as a function of β grain size and the behaviour was compared with that of Ti-10V-2Fe-3Al alloy. It was found that this alloy,
unlike the Ti-10V-2Fe-3Al alloy, did not exhibit any stress induced martensitic transformation during tensile testing. This
was attributed to the higher stability of the β phase in this alloy as compared to that in Ti-10V-2Fe-3Al alloy because of
the higher iron content. The yield strength, ultimate tensile strength, total elongation and fracture toughness in this alloy
were found to decrease with increase in grain size. The yield strength of this alloy was found to obey the Hall-Petch relationship
with grain size, similar to the observation in Ti-10V-2Fe-3Al alloy. However, the σi value was higher and k value lower than that observed in Ti-10V-2Fe-3Al alloy. The fracture toughness in Ti-10V-4.5Fe-3Al
alloy was also found to increase linearly with inverse square root of grain size; however, the slope was significantly less
than that observed in Ti-10V-2Fe-3Al alloy. 相似文献
Computer vision software is complex, involving many tens of thousands of lines of code. Coding mistakes are not uncommon. When the vision algorithms are run on controlled data which meet all the algorithm assumptions, the results are often statistically predictable. This renders it possible to statistically validate the computer vision software and its associated theoretical derivations. In this paper, we review the general theory for some relevant kinds of statistical testing and then illustrate this experimental methodology to validate our building parameter estimation software. This software estimates the 3D positions of buildings vertices based on the input data obtained from multi-image photogrammetric resection calculations and 3D geometric information relating some of the points, lines and planes of the buildings to each other. 相似文献
Digital Signal Processing (DSP) is widely used in high-performance media processing and communication systems. In majority of these applications, critical DSP functions are realized as embedded cores to meet the low-power budget and high computational complexity. Usually these cores are ASICs that cannot be easily retargeted for other similar applications that share certain commonalities. This stretches the design cycle that affects time-to-market constraints. In this paper, we present a reconfigurable high-performance low-power filter coprocessor architecture for DSP applications. The coprocessor architecture, apart from having the performance and power advantage of its ASIC counterpart, can be reconfigured to support a wide variety of filtering computations. Since filtering computations abound in DSP applications, the implementation of this coprocessor architecture can serve as an important embedded hardware IP. 相似文献
Quartz is widely replaced by fly ash in traditional porcelain composite. Increased strength and stability of the fly ash-mixed composite depends on the quantity and crystallinity of the mullite phase in the fly ash. Our aim in this investigation is to increase the formation of mullite in nanocrystalline form and study the effect of temperature. Quantitative estimation of mullite and residual quartz content were done by X-ray diffraction (XRD) and nanostructure and crystallization were studied using differential thermal analysis (DTA), field effect scanning electron microscopy (FESEM), XRD and Fourier transform infrared (FTIR) spectroscopy. The results show that fly ash sieved through 250 holes/cm2 mesh contain more mullite initially and growth of mullite as well as glass formation was faster in this sample compared to coarse fly ash. The maximum mullite in these samples was formed at 1600°C. Transformation of quartz and cristobalite phases into glassy phase was also faster for smaller particle sizes of fly ash. 相似文献