Influence of water content in sub-flooring materials using adhesive on chemical compounds emission

Indoor air pollution is caused predominantly by emission of primary pollutants from building materials or finishing materials. Recently, there has been increasing interest in the new secondary pollutants caused by chemical reaction of the primary pollutants. In this study, the pollutants emitted from poly(vinyl chloride) (PVC) flooring material were measured, and 2-ethyl-1-hexanol (2E1H) and volatile organic compounds (VOCs) emitted from composite building materials made of PVC flooring material used as a self-leveling flooring were measured to identify the mechanism of emission of 2E1H. The moisture sorption isotherm was measured with a Magnetic Suspension Balance to examine the moisture content of the self-leveling flooring material and its effect on emission of 2E1H. 2E1H was emitted from the PVC flooring material through hydrolysis or oxidation of di-2-ethylhexyl phthalate (DEHP). The composite building material including the self-leveling flooring material emitted more 2E1H through hydrolysis over time. It was determined that liquid prevails in the self-leveling flooring material when the water content is higher than 4% and vapor prevails when the water content is lower than 4%. The prevailing liquid in the flooring material contributes to the increased emission of 2E1H and the prevailing vapor in the material did not cause increase in emission of 2E1H. It is considered that control of water in the self-leveling flooring material or concrete slab is very important in order to inhibit emission of 2E1H through hydrolysis of DEHP on the floor.     

Synthetic Molecular Gear Based on Double-Decker Porphyrin Complexes

New rotary molecular machines (1 and 2) were synthetically constructed from two distinct porphyrin-based rotors, a cerium(IV) bis(porphyrinate)s double-decker (CeDD) and a porphyrinatorhodium(III)-based rotor. These rotors are adjacently mounted on rotational axes aligned to near vertical as resembling the bevel-gear-shaped structure. Structural study using NMR analysis reveals that these distinct rotors are connected through a coordination bond between rhodium(III) and a pyridyl group. At temperature from 193 to 393 K, each rotor represents rotational motion driven by heat fluctuation without decomposition into the corresponding precursors in dichloromethane-d ₂ and tetrachloroethane-d ₄. Importantly, the mechanical interaction between the teeth of these rotors is strongly dependent on the central metal atom in a DD rotor and the teeth structure in a porphyrinatorhodium(III)-based rotor. Understanding such relationship between the chemical structures and mechanical interaction is of importance for generating cooperative motion in the hybrid machinery system.     

Hydrogen-bond-assisted isotactic-specific radical polymerization of N-isopropylacrylamide with pyridine N-oxide

Radical polymerization of N-isopropylacrylamide (NIPAAm) in CHCl₃ at low temperatures in the presence of pyridine N-oxide (PNO) was investigated. An isotactic poly(NIPAAm) with meso diad content of 61% was successfully prepared at −60 °C in the presence of a two-fold amount of PNO. Thermodynamic analysis suggested that the isotactic-specificity was entropically induced, probably due to conformational fixation near the propagating chain-end through coordination by PNO.     

Metastatic Voyage of Ovarian Cancer Cells in Ascites with the Assistance of Various Cellular Components

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and has a unique metastatic route using ascites, known as the transcoelomic root. However, studies on ascites and contained cellular components have not yet been sufficiently clarified. In this review, we focus on the significance of accumulating ascites, contained EOC cells in the form of spheroids, and interaction with non-malignant host cells. To become resistant against anoikis, EOC cells form spheroids in ascites, where epithelial-to-mesenchymal transition stimulated by transforming growth factor-β can be a key pathway. As spheroids form, EOC cells are also gaining the ability to attach and invade the peritoneum to induce intraperitoneal metastasis, as well as resistance to conventional chemotherapy. Recently, accumulating evidence suggests that EOC spheroids in ascites are composed of not only cancer cells, but also non-malignant cells existing with higher abundance than EOC cells in ascites, including macrophages, mesothelial cells, and lymphocytes. Moreover, hetero-cellular spheroids are demonstrated to form more aggregated spheroids and have higher adhesion ability for the mesothelial layer. To improve the poor prognosis, we need to elucidate the mechanisms of spheroid formation and interactions with non-malignant cells in ascites that are a unique tumor microenvironment for EOC.     

Correlations of Hepatic Hemodynamics,Liver Function,and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus

The progression of chronic liver disease differs by etiology. The aim of this study was to elucidate the difference in disease progression between chronic hepatitis C (CHC) and nonalcoholic fatty liver disease (NAFLD) by means of fibrosis markers, liver function, and hepatic tissue blood flow (TBF). Xenon computed tomography (Xe-CT) was performed in 139 patients with NAFLD and 152 patients with CHC (including liver cirrhosis (LC)). The cutoff values for fibrosis markers were compared between NAFLD and CHC, and correlations between hepatic TBF and liver function tests were examined at each fibrosis stage. The cutoff values for detection of the advanced fibrosis stage were lower in NAFLD than in CHC. Although portal venous TBF (PVTBF) correlated with liver function tests, PVTBF in initial LC caused by nonalcoholic steatohepatitis (NASH-LC) was significantly lower than that in hepatitis C virus (C-LC) (p = 0.014). Conversely, the liver function tests in NASH-LC were higher than those in C-LC (p < 0.05). It is important to recognize the difference between NAFLD and CHC. We concluded that changes in hepatic blood flow occurred during the earliest stage of hepatic fibrosis in patients with NAFLD; therefore, patients with NAFLD need to be followed carefully.     

Application of magnetic nanoparticles to gene delivery

Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as well as clinical diagnostic and therapeutic applications. For example, nanoparticles hold great promise for enabling gene therapy to reach its full potential by facilitating targeted delivery of DNA into tissues and cells. Substantial progress has been made in binding DNA to nanoparticles and controlling the behavior of these complexes. In this article, we review research on binding DNAs to nanoparticles as well as our latest study on non-viral gene delivery using polyethylenimine-coated magnetic nanoparticles.     

An optical field-induced ionization X-ray laser using a preformedplasma scheme

Soft X-ray amplification by optical field-induced ionization (OFI) of a preformed plasma is investigated. A small-signal gain of 20 cm^-1 and a gain-length product of 4 at 13.5 nm on the Lyman-α transition in hydrogen-like lithium have been obtained using the modified OFI scheme. Experimental and numerical results ensure that we have produced a plasma with a significantly lower electron temperature than what is expected by an above-threshold ionization model. To explain the results, a two component plasma model in which relatively high temperature electrons are produced by OFI in a cold electron bath of the preformed plasma is presented. The model indicates that the average electron temperature of the OFI plasma rapidly decreases since a high-temperature part of the electrons escapes from the focal volume without interaction. The initial electrons produced prior to the field ionization, which survive after the OEI, also significantly contribute to the rapid three-body recombination. Based on the ionization-induced refractive index change, the pulse propagation of a high-intensity pump laser during the OFI is also discussed     

Surface modification of III-V compound semiconductors using surfaceelectromagnetic wave etching induced by ultraviolet lasers

The surface modification of semiconductors by laser-induced surface electromagnetic wave (SEW) etching was investigated. With the novel etching method using a holographic exposure system, submicron periodic dot structures were fabricated directly on semiconductor substrates (n-InP, n-GaAs, and InGaAs-InP). Making use of laser polarization dependence in this etching system, a variety of surface modifications could be achieved on the semiconductors. In particular, in the case of using the s-polarization light, periodic submicron dot structures with a geometrical diameter down to 80 nm could be obtained directly using a single-step process without a mask. The InGaAs-InP dot structures were studied optically by means of photoluminescence spectroscopy, and the blue shift of the photoluminescence energy up to 5.36 meV was observed for the smallest dots, which displayed a lateral quantization     

Performances of metal fluoride added carbon anodes with pre-electrolysis for electrolytic synthesis of NF3

Metal fluoride added carbon anodes treated by pre-electrolysis were investigated for electrolytic production of nitrogen trifluoride (NF₃) in molten NH₄F·KF·4HF at 100 °C. The conditions for pre-electrolysis were first optimized using a graphite sheet anode as a model anode. The formation of fluorine-graphite intercalation compounds (fluorine-GICs) with semi-covalent C–F bonds, (C_xF)_n, on the MgF₂ and CaF₂ added carbon anode surface was accelerated by pre-electrolysis at potentials less than 4.0 V. Critical current densities (CCD) on the MgF₂ added carbon anodes pre-electrolyzed under various conditions were determined, and the highest CCD was 290 mA cm⁻² obtained for that pre-electrolyzed at 3.5 V for 500 C cm⁻². This anode was successfully used in the electrolysis at 100 mA cm⁻² for 290 h and the maximum NF₃ current efficiency was 55%. From these results, it was concluded that the metal fluoride added carbon anode treated by pre-electrolysis has a high potential for electrolytic production of NF₃ at higher current density.     

Co‐injection molding of PVC with other thermoplastics: Processing,properties, and applications

Rigid poly(vinyl chloride) (PVC) was co‐injected with glass‐fiber‐reinforced PVC (GFR‐PVC), polypropylene (PP), acrylonitrile‐butadiene‐styrene copolymer (ABS), and polycarbonate (PC) by using the Mono‐sandwich co‐injection process. Up to three through‐thickness skin‐core morphologies were observed along the length of the sample. Near the gate, the core was always a single, continuous layer. In some cases, the core diverged into multiple or discontinuous layers. Farther from the gate, flow of the core ceased, leaving a skin‐only region. The skin and core layers were more uniformly distributed through the test plaque when injection speed was low. Adhesion between PVC and PP was poor. Skin and core layers delaminated, and mechanical properties were poor. The PVC adhered well to GFR‐PVC, ABS, and PC. No layer delamination occurred, and mechanical properties were intermediate between those of the skin and core components alone. Dropped dart impact energy was controlled more by the skin layer than the core. In rigid PVC/GFR‐PVC co‐injected samples, impact energy was 2.5 times greater when GFR‐PVC was the core than when GFR‐PVC was the skin.