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61.
In this paper, we propose an approach to balance the legitimate and yet conflicting perspectives between standardization and reconfiguration embedded within hospital information systems (HIS) design activities. We report on an action research study of the customization process of an electronic triage and tracking system that was reconfigured to be used in eight Canadian emergency departments. We argue that during HIS design activities, it is essential for both practitioners and system designers to articulate and identify which aspects can be standardized without constraining important local flexibility and which aspects require local reconfiguration to function in a particular work context. To identify these differences, we suggest an analytical distinction between boundary factors and contextual contingencies, which can be used in a design and reconfiguration process. We argue that the process of designing shared electronic templates should be perceived as a common design process, where multiple stakeholders articulate, identify, and negotiate boundary factors and contextual contingencies. Boundary factors are then represented within the shared electronic system, whereas contextual contingencies form the basis for constructing localized versions of the shared application. All local versions include both boundary factors and the reconfigured contextual contingencies.  相似文献   
62.
The problem of counting the number of solutions to a constraint network (CN) (also called constraint satisfaction problems, CSPs) is rephrased in terms of probability updating in Bayes networks. Approximating the probabilities in Bayes networks is a problem which has been studied for a while, and may well provide a good approximation to counting the number of solutions. We use a simple approximation based on independence, and show that it is correct for tree‐structured CNs. For other CNs, it is less optimistic than a spanning‐tree approximation suggested in prior work. Experiments show that the Bayes nets estimation is more accurate on the average, compared to competing methods (the spanning‐tree, as well as a scheme based on a product of all compatible pairs of values). We present empirical evidence that our approximation may also be a useful (value ordering) search heuristic for finding a single solution to a constraint satisfaction problem. This revised version was published online in June 2006 with corrections to the Cover Date.  相似文献   
63.
Digital fingerprinting is a technology for tracing the distribution of multimedia content and protecting them from unauthorized redistribution. Unique identification information is embedded into each distributed copy of multimedia signal and serves as a digital fingerprint. Collusion attack is a cost-effective attack against digital fingerprinting, where colluders combine several copies with the same content but different fingerprints to remove or attenuate the original fingerprints. In this paper, we investigate the average collusion attack and several basic nonlinear collusions on independent Gaussian fingerprints, and study their effectiveness and the impact on the perceptual quality. With unbounded Gaussian fingerprints, perceivable distortion may exist in the fingerprinted copies as well as the copies after the collusion attacks. In order to remove this perceptual distortion, we introduce bounded Gaussian-like fingerprints and study their performance under collusion attacks. We also study several commonly used detection statistics and analyze their performance under collusion attacks. We further propose a preprocessing technique of the extracted fingerprints specifically for collusion scenarios to improve the detection performance.  相似文献   
64.
An optical calibration source for free-space systems with large beams is presented. It produces a 2 W, 370 mm beam tunable from 1545-1570 nm with a wavefront error of 相似文献   
65.
Local electrochemical impedance spectroscopy provides a powerful tool for the investigation of surface heterogeneities on electrode surfaces. However, measurements are greatly influenced by geometry-induced frequency dispersion. In order to account for this frequency dispersion, both simulations and experiments were performed to explore the influence of a recessed electrode on the local and global impedance response. The calculations presented here demonstrated that the depth of the recessed electrode required to achieve a uniform primary current distribution was twice the electrode radius. The calculations provide guidelines for design of LEIS measurements, and were in good agreement with results obtained for a stainless steel disk electrode in a Na2SO4 electrolyte.  相似文献   
66.
    
This paper presents an Artificial Immune System (AIS)-based model for cooperative control of multiagent systems. This cooperative control model describes collective behaviors of autonomous agents, known as the AIS agents that are exemplified by the regulated activities performed by individual agents under the computation paradigm of Artificial Immune System. The regulations and emergence of agent behaviors are derived from the immune threshold measures that determine those activities performed by the AIS agents at an individual level. These threshold measures together with the collective behavioral model defined the cooperative control of the AIS-based control framework under which AIS agents behave and act strategically according to the changing environment. The cooperative control model is presented under the three domains, namely exploration, achievement and cooperation domains where AIS agents operate. In this research, we implemented the proposed cooperative control model with a case study of automated material handling with a group of AIS agents that cooperate to achieve the defined tasks.  相似文献   
67.
Since many years, the role of the colonic microbiota in maintaining the host's overall health and well-being has been recognized. Dietary modulation of the microbiota composition and activity has been achieved by the use of pre-, pro- and synbiotics. In this review, we will summarize the available evidence on the modification of bacterial metabolism by dietary intervention with pre-, pro- and synbiotics. Enhanced production of SCFA as a marker of increased saccharolytic fermentation is well documented in animal and in vitro studies. Decreased production of potentially toxic protein fermentation metabolites, such as sulfides, phenolic and indolic compounds, has been less frequently demonstrated. Besides, pre-, pro- and synbiotics also affect other metabolic pathways such as the deconjugation of secondary bile acids, bacterial enzyme activities and mineral absorption. Data from human studies are less conclusive. The emergence of new analytical techniques such as metabolite profiling has revealed new pathways affected by dietary intervention. However, an important challenge for current and future research is to relate changes in bacterial metabolism to concrete health benefits. Potential targets and expected benefits have been identified: reduced risk for the metabolic syndrome and prevention of colorectal cancer.  相似文献   
68.
    
Scope: Health benefits of prebiotic administration have been judged mainly from the increased numbers of bifidobacteria and the enhanced production of short‐chain fatty acids in the colon. Only a few studies have focused on the capacity of prebiotics to decrease the proteolytic fermentation, which might contribute to health as well. Methods and results: The influence of the prebiotic oligofructose‐enriched inulin (OF‐IN) on the pattern of volatile organic compounds was characterized using an in vitro faecal model. Faecal slurries, obtained from healthy subjects, were anaerobically incubated at 37°C with and without different doses of OF‐IN (2.5, 5, 10, or 20 mg) and changes in the metabolite pattern and pH were evaluated. A total of 107 different volatile organic compounds were identified and classified according to their chemical classes. The concentration of esters and acids significantly increased with increasing doses of OF‐IN. Similar effects were observed for some aldehydes. To the contrary, OF‐IN dose‐dependently inhibited the formation of S‐compounds. Also, the generation of other protein fermentation metabolites such as phenolic compounds was inhibited in the presence of OF‐IN. Conclusion: Our results confirmed a clear dose‐dependent stimulation of saccharolytic fermentation. Importantly, a significant decrease in toxic protein fermentation metabolites such as sulphides attended these effects.  相似文献   
69.
    
ABSTRACT

Extensive literature exists for simple and exact expressions of symbol error rate (SER) over fading channels under different modulation schemes whose boundaries meet at right angles. In cases where boundaries do not meet at right angles, integrals of special function in the expressions make the exact calculation most complex. In such cases only approximate solutions are possible. Also, it is noteworthy to mention that when detection is performed with proper use of the phase (phase-jitter-based approach), noise performance of the receiver improves significantly. This paper applies phase-jitter PDF-based approach to present exact and closed-form SER expression of MPSK scheme over Mixture Gamma (MG) distribution for an arbitrary array of signal points. The proposed expression is generic as MG distribution can be approximated in almost all fading/shadowed fading channel models. As a proof to the authenticity, SERs of MPSK scheme over Rayleigh and Nakagami-m fading channels are deduced from the proposed SER over generalised MG distribution. Further, a significant improvement in SER has been achieved with phase-jitter-based approach as compared to conventional (non-phase-jitter-based) approach. Finally, to confirm the correctness of the proposed expression, results are validated through comparison with the existing results and Monte Carlo simulation.  相似文献   
70.
    
Background: The emergence and diffusion of strains of pathogenic bacteria resistant to antibiotics constitutes a real public health challenge. Antibiotic resistance genes (ARGs) can be carried by both pathogenic and non-pathogenic bacteria, including commensal bacteria from the human microbiota, which require special monitoring in the fight against antimicrobial resistance. Methods: We analyzed the proteomes of 335 new bacterial species from human microbiota to estimate its whole range of ARGs using the BLAST program against ARGs reference databases. Results: We found 278 bacteria that harbor a total of 883 potential ARGs with the following distribution: 264 macrolides-lincosamides-streptogramin, 195 aminoglycosides, 156 tetracyclines, 58 β-lactamases, 58 fosfomycin, 51 glycopeptides, 36 nitroimidazoles, 33 phenicols and 32 rifamycin. Furthermore, evolutionary analyses revealed the potential horizontal transfer with pathogenic bacteria involving mobile genetic elements such as transposase and plasmid. We identified many ARGs that may represent new variants in fosfomycin and β-lactams resistance. Conclusion: These findings show that new bacterial species from human microbiota should be considered as an important reservoir of ARGs that can be transferred to pathogenic bacteria. In vitro analyses of their phenotypic potential are required to improve our understanding of the functional role of this bacterial community in the development of antibiotic resistance.  相似文献   
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