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排序方式: 共有554条查询结果,搜索用时 15 毫秒
21.
Francesca Bugli Federica Massaro Francesco Buonocore Paolo Roberto Saraceni Stefano Borocci Francesca Ceccacci Cecilia Bombelli Maura Di Vito Rosalba Marchitiello Melinda Mariotti Riccardo Torelli Maurizio Sanguinetti Fernando Porcelli 《International journal of molecular sciences》2022,23(4)
The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigated the in vitro and in vivo antifungal activity of three short myristoylated and non-myristoylated peptides derived from a mutant of the AMP Chionodracine. We determined their interaction with anionic and zwitterionic membrane-mimicking vesicles and their structure during this interaction. We then investigated their cytotoxic and hemolytic activity against mammalian cells. Lipidated peptides showed a broad spectrum of activity against a relevant panel of pathogen fungi belonging to Candida spp., including the multidrug-resistant C. auris. The antifungal activity was also observed vs. biofilms of C. albicans, C. tropicalis, and C. auris. Finally, a pilot efficacy study was conducted on the in vivo model consisting of Galleria mellonella larvae. Treatment with the most-promising myristoylated peptide was effective in counteracting the infection from C. auris and C. albicans and the death of the larvae. Therefore, this myristoylated peptide is a potential candidate to develop antifungal agents against human fungal pathogens. 相似文献
22.
Sylvain Lamoine Mlissa Cumenal David A. Barriere Vanessa Pereira Mathilde Fereyrolles Laëtitia Prival Julie Barbier Ludivine Boudieu Emilie Brasset Benjamin Bertin Yoan Renaud Elisabeth Miot-Noirault Marie-Ange Civiale David Balayssac Youssef Aissouni Alain Eschalier Jrme Busserolles 《International journal of molecular sciences》2022,23(1)
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Electrical contact resistance between stainless steel bipolar plate and carbon felt in PEFC: A comprehensive study 总被引:1,自引:0,他引:1
Johan André Laurent Antoni Jean-Pierre Petit Eric De Vito Alexandre Montani 《International Journal of Hydrogen Energy》2009
Bipolar plate represents a key component of Proton Exchange Membrane Fuel Cell (PEFC) with several essential functions, among them the electric connection of elementary cells. Usually made of graphite, this component is studied worldwide in order to develop a commercially viable alternative: different ways have been being investigated, and to date, despite corrosion issues, stainless steel (SS) appears as a good candidate material, but its Electrical Contact Resistance (ECR) can reach unacceptable values when exposed to PEFC environment. This paper offers a comprehensive study of the parameters acting on ECR when using uncoated SS in PEFC: roughness, which influences the surface contact area with carbon baking, bulk composition of the alloy, which influences only partly the nature of passive films, and the composition and structure of passive films, strongly modified by surface treatments and ageing conditions. 相似文献
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Antonino Rizzuti Rocco Caliandro Vito Gallo Piero Mastrorilli Giuseppe Chita Mario Latronico 《Food chemistry》2013
X-ray powder diffraction was combined, for the first time, with Nuclear Magnetic Resonance spectroscopy and direct infusion mass spectrometry to characterise fresh and brined grape leaves. Covariance analysis of data generated by the three techniques was performed with the aim to correlate information deriving from the solid part with those obtained for soluble metabolites. The results obtained indicate that crystalline components can be correlated to the metabolites contained in the grape leaves, paving the way to the use of X-ray diffraction analysis for food fingerprinting purposes. Moreover it was ascertained that, differently from most of the metabolites present in the fresh vine leaves, linolenic acid (an omega-3-fatty acid) and quercetin-3-O-glucuronide (a polyphenol metabolite) do not undergo sensible degradation during the brining process, which is used as preservative method for the grape leaves. 相似文献
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Evolution of the oxidative stability,bio‐active compounds and color characteristics of non‐thermally treated vegetable pâtés during frozen storage
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29.
In this paper a three stage procedure is presented for deriving parameters bounds of SISO Wiener models when the nonlinear block is modeled by a possibly noninvertible polynomial and the output measurement errors are bounded. First, using steady-state input-output data, parameters of the nonlinear part are bounded by a tight orthotope. Then, given the estimated uncertain nonlinearity and the output measurements collected exciting the system with an input dynamic signal, bounds on the unmeasurable inner signal are computed. Finally, such bounds, together with noisy output measurements, are used for bounding the parameters of the linear block. 相似文献
30.
The link between occupation and musculoskeletal disorders has been focused on in numerous research projects, ranging from those simply observing the different pathological findings reported among workers performing particular tasks, down to the latest studies actually quantifying the 'exposure' of workers to physical and psychosocial stimuli. For some disorders and certain tissues, it has been reported that specific types of work-related exposure are associated with the development of musculoskeletal pathologies, and that the relative risks for certain types of occupational exposure can be extremely high. This has been proven in relation to tendinitis of the shoulder and hand-wrist, carpal tunnel syndrome, as well as several localized aspecific musculoskeletal symptoms, such as pain. For other pathologies, the studies reported contradictory results. This is the case for lateral epicondylitis and cervical radiculopathy. 相似文献