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111.
Kuczewski B Marquardt CM Seibert A Geckeis H Kratz JV Trautmann N 《Analytical chemistry》2003,75(24):6769-6774
Capillary electrophoresis (CE) was coupled to ICPMS in order to combine the good performance of this separation technique with the high sensitivity of the ICPMS for the analysis of plutonium and neptunium oxidation states. The combination of a fused-silica capillary with a MicroMist AR 30-I-FM02 nebulizer and a Cinnabar small-volume cyclonic spray chamber yielded the best separation results. With this setup, it was possible to separate a model element mixture containing neptunium (NpO2(+)), uranium (UO2(2+)), lanthanum (La3+), and thorium (Th4+) in 1 M acetic acid. The same conditions were also suitable for the separation of various oxidation states of plutonium and neptunium in different aqueous samples. All separations were obtained within less than 15 min. A detection limit of 50 ppb identical with 2 x 10(-7) M (3-fold standard deviation of a blank) was achieved. To prove the negligible disturbance of the plutonium and neptunium redox equilibria during the CE separations, plutonium and neptunium speciation by CE-ICPMS in acidic solutions was compared with the results of UV/visible absorption spectroscopy and was found to be in good agreement. The CE-ICPMS system was also applied to study the reduction of Pu(VI) in a humic acid-containing groundwater at different pH values. 相似文献
112.
Willkomm DK Gruegelsiepe H Goudinakis O Kretschmer-Kazemi Far R Bald R Erdmann VA Hartmann RK 《Chembiochem : a European journal of chemical biology》2003,4(10):1041-1048
RNA has gained increasing importance as a therapeutic target. However, so far mRNAs rather than stable cellular RNAs have been considered in such studies. In bacteria, the tRNA-processing enzyme RNase P has a catalytic RNA subunit. Fundamental differences in structure and function between bacterial and eukaryotic RNase P, and its indispensability for cell viability make the bacterial enzyme an attractive drug target candidate. Herein we describe two approaches utilized to evaluate whether the catalytic RNA subunit of bacterial RNase P is amenable to inactivation by antisense-based strategies. In the first approach, we rationally designed RNA hairpin oligonucleotides targeted at the tRNA 3'-CCA binding site (P15 loop region) of bacterial RNase P RNA by attempting to include principles derived from the natural CopA-CopT antisense system. Substantial inactivation of RNase P RNA was observed for Type A RNase P RNA (such as that in Escherichia coli) but not for Type B (as in Mycoplasma hyopneumoniae). Moreover, only an RNA oligonucleotide (Eco 3') complementary to the CCA binding site and its 3' flanking sequences was shown to be an efficient inhibitor. Mutation of Eco 3' and analysis of other natural RNase P RNAs with sequence deviations in the P15 loop region showed that inhibition is due to interaction of Eco 3' with this region and occurs in a highly sequence-specific manner. A DNA version of Eco 3' was a less potent inhibitor. The potential of Eco 3' to form an initial kissing complex with the P15 loop did not prove advantageous. In a second approach, we tested a set of oligonucleotides against E. coli RNase P RNA which were designed by algorithms developed for the selection of suitable mRNA targets. This approach identified the P10/11-J11/12 region of bacterial RNase P RNA as another accessible region. In conclusion, both the P15 loop and P10/11-J11/12 regions of Type A RNase P RNAs seem to be promising antisense target sites since they are easily accessible and sufficiently interspersed with nonhelical sequence elements, and oligonucleotide binding directly interferes with substrate docking to these two regions. 相似文献
113.
Tim Reichling Michael Veith Volker Wulf 《Computer Supported Cooperative Work (CSCW)》2007,16(4-5):431-465
Recent knowledge management initiatives focus on expertise sharing within formal organizational units and informal communities of practice. Expert recommender systems seem to be a promising tool in support of these initiatives. This paper presents experiences in designing an expert recommender system for a knowledge-intensive organization, namely the National Industry Association (NIA). Field study results provide a set of specific design requirements. Based on these requirements, we have designed an expert recommender system which is integrated into the specific software infrastructure of the organizational setting. The organizational setting is, as we will show, specific for historical, political, and economic reasons. These particularities influence the employees’ organizational and (inter-)personal needs within this setting. The paper connects empirical findings of a long-term case study with design experiences of an expertise recommender system. 相似文献
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115.
Oscar Almer Igor Böhm Tobias Edler von Koch Björn Franke Stephen Kyle Volker Seeker Christopher Thompson Nigel Topham 《International journal of parallel programming》2013,41(2):212-235
In recent years multi-core processors have seen broad adoption in application domains ranging from embedded systems through general-purpose computing to large-scale data centres. Simulation technology for multi-core systems, however, lags behind and does not provide the simulation speed required to effectively support design space exploration and parallel software development. While state-of-the-art instruction set simulators (Iss) for single-core machines reach or exceed the performance levels of speed-optimised silicon implementations of embedded processors, the same does not hold for multi-core simulators where large performance penalties are to be paid. In this paper we develop a fast and scalable simulation methodology for multi-core platforms based on parallel and just-in-time (Jit) dynamic binary translation (Dbt). Our approach can model large-scale multi-core configurations, does not rely on prior profiling, instrumentation, or compilation, and works for all binaries targeting a state-of-the-art embedded multi-core platform implementing the ARCompact instruction set architecture (Isa). We have evaluated our parallel simulation methodology against the industry standard Splash-2 and Eembc MultiBench benchmarks and demonstrate simulation speeds up to 25,307 Mips on a 32-core x86 host machine for as many as 2,048 target processors whilst exhibiting minimal and near constant overhead, including memory considerations. 相似文献
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117.
Dr. Gunther Kolb Dipl.‐Ing. Hans‐Joachim Kost Prof. Dr. Volker Hessel Prof. Dr. Volker Hessel 《化学,工程师,技术》2011,83(4):465-478
In this contribution it is reported about the realization of efficient micro rectification equipment (MRA), which can be operated intermittently or continuously and be used both for analytical as well as for preparative separations of mixtures of liquid substances. Different binary systems were separated. A theoretical separation stage number of 12 was obtained together with a height equivalent to one theoretical plate of 1.08 cm. Compared to the state of microtechnology this can be regarded as an excellent progress. 相似文献
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Christin Hengst Susanne Werner Lars Müller Kati Fröhlich Volker Böhm 《European Food Research and Technology》2009,230(2):249-254
The aim of the present analysis was to study the influence of the sample concentration on the measured antioxidant capacity, since such investigations are scarce but necessary to ensure the reproducibility of the results. Pure substances (ascorbic acid, gallic acid, Trolox®, uric acid) and food extracts (strawberry nectar, tomato extract, white tea) were analysed using seven common antioxidant capacity assays (three versions of Trolox equivalent antioxidant capacity, TEAC; ferric reducing antioxidant power, FRAP; photochemiluminescence, PCL; oxygen radical absorbance capacity, ORAC and total phenolics assay). For all applied pure substances and in most of the assays effects of the sample concentration on the measured antioxidant capacity were observed. Since it remains speculative how sample concentration does affect the measured antioxidant capacity exactly, it is strongly recommended to use at least three sample concentrations for analysis to detect and to discuss concentration-dependent effects. 相似文献