Validation of a morphometric reconstruction technique applied to a juvenile pelvis

Three-dimensional reconstructions of bone geometry from microCT (computed tomography) data are frequently used in biomechanical and finite element analyses. Digitization of bone models is usually a simple process for specimens with a complete geometry, but in instances of damage or disarticulation it can be very challenging. Subsequent to digitization, further imaging techniques are often required to estimate the geometry of missing bone or connecting cartilage. This paper presents an innovative approach to the reconstruction of incomplete scan data, to reproduce proper anatomical arrangements of bones, including absent connecting cartilaginous elements. Utilizing geometric morphometric tools, the reconstruction technique is validated through comparison of a reconstructed 9 year old pelvis, to the original CT data. A principal component analysis and an overlay of the two pelves provide a measure of the accuracy of the reconstructed model. Future work aims to investigate the biomechanical effects of any minor positional error on the bone's predicted structural properties through the use of finite element analysis.     

Estimating channel‐forming discharge in urban watercourses

Several methods of estimating channel‐forming discharge were conducted on 12 quasi‐stable urban stream channels ranging from 9 to 99% urban land use to test their applicability in the urban condition. Bankfull stage was identified at a series of locations along each study reach and it was found that the most consistent observations of bankfull discharge occurred during flood conditions where bankfull stage was identified at the top of point bars along the convex arc of bends. The largest errors in estimation occurred at gauge stations where cross‐sectional geometry had been altered to conform to bridges or culverts rather than the channel morphology. Independent evaluations of channel forming discharge were conducted by 11 practitioners ranging from 10 years to 43 years of experience with similar findings and errors. Various methods of relating frequency return periods were evaluated using annual peak series discharge observations and continuous 15‐min systematic discharge records using partial duration series analysis. Bankfull discharge was observed to occur more than once a year in all of the urban streams studied and often averaged from 4 to 8 bankfull discharge or larger events per year. In one particular case in a single given year 18 events exceeding bankfull discharge were observed. No specific correlations were identified between frequency return periods and land use change. However, based upon the findings of this study, the applicability of employing annual series peak discharge data to evaluate bankfull frequency return in urban stream channels is highly discouraged. Copyright © 2010 John Wiley & Sons, Ltd.     

Simulated environments with animated agents: effects on visual attention,emotion, performance,and perception

This research assessed how emotive animated agents in a simulation‐based training affect the performance outcomes and perceptions of the individuals interacting in real time with the training application. A total of 56 participants consented to complete the study. The material for this investigation included a nursing simulation in which participants interacted with three animated agents. The results of this investigation indicated that both experienced and novice participants focused more visual attention time on the body of the animated agent than the other defined areas of interest in the simulated environment. The results also indicated that novice participants conveyed more neutral facial expressions during the interaction with the animated agents than experience participants. The results of the simulation performance scores indicated that novice participants achieved higher simulation performance scores on the simulation task than experienced participants. Lastly, the results of the agent persona instrument showed that experienced and novice participants perceived the animated agents as facilitators of learning, credible, human‐like and engaging.     

Designing for attention with sound: challenges and extensions to ecological interface design

OBJECTIVE: We explore whether ecological interface design (EID) principles can be applied to the design of an auditory display for anesthesia monitoring. BACKGROUND: EID examples focus almost exclusively on visual displays. In the anesthesia work environment, however, auditory displays may provide better individual and team awareness of patient state. METHOD: Using a work domain analysis of physiological monitoring in anesthesia, we identify information to display. Using the skills, rules, and knowledge distinction we identify cognitive control needed. Using semantic mapping we map physiological variables and constraints to auditory dimensions. RESULTS: EID principles do not address when information should be displayed and to whom. An attentional mapping stage helps to specify answers to these questions so that a workable auditory display for anesthesia monitoring is achieved. CONCLUSION: EID principles of representing work domain functional structure and minimizing resource-demanding cognitive control are necessary but insufficient to specify requirements for an effective auditory display. Also needed are analyses of control tasks, strategies, and the social organization of work. Such analyses are an integral part of the broader cognitive work analysis framework from which EID emerged. APPLICATION: Actual or potential uses of this research include the design of displays that support continuous peripheral awareness in collaborative multimodal work environments.     

Quantification of heart fatty acid binding protein as a biomarker for drug-induced cardiac and musculoskeletal necroses

Heart fatty acid binding protein (Fabp3) is a cytosolic protein expressed primarily in heart, and to a lesser extent in skeletal muscle, brain, and kidney. During myocardial injury, the Fabp3 level in serum is elevated rapidly, making it an ideal early marker for myocardial infarction. In this study, an MS‐based selected reaction monitoring method (LC‐SRM) was developed for quantifying Fabp3 in rat serum. Fabp3 was enriched first through an immobilized antibody, and the protein was digested on beads directly. A marker peptide of Fabp3 was quantified using LC‐SRM with a stable isotope‐labeled peptide standard. For six quality control samples with Fabp3 ranging from 0.256 to 25 ng, the average recovery following the procedure was about 73%, and the precision (%CV) between replicates was less than 7%. The Fabp3 concentrations in rat serum peaked 1 h after isoproterenol treatment, and returned to baseline levels 24 h after the dose. Elevated Fabp3 levels were also detected in rats administered with a PPAR α/δ agonist, which has shown to cause skeletal muscle necrosis. Fabp3 can be used as a biomarker for both cardiac and skeletal necroses. The cross‐validation of the LC‐SRM method with an existing ELISA method is described.     

Quasi‐equilibrium conditions of urban gravel‐bed stream channels in southern Ontario,Canada

Urban gravel‐bed stream channels in southern Ontario, Canada identified to be in a state of quasi‐equilibrium have been studied over the past 15 years and compared against rural gravel bed stream channels of the same hydrophysiographic region. Bankfull width and depth versus bankfull discharge were not found to increase as a function of increasing urbanization as has been found in many other studies. The observed annual frequency of bankfull discharge was typically less than a 1‐year return period with many sites ranging between 2 and 18 bankfull events per year with higher intensity and shorter duration urban flood responses, which further identified significant limitations in using annual peak discharge methods for predicting morphological forming flows in urban watersheds. The cumulative volume of bankfull and larger flood events from the urban stream channels were very similar to the same annual event volumes in the rural comparison study reaches. Bed material supply was found to decrease with increasing urbanization and the reduction in bed material supply appears to be off‐set by the smaller bankfull channel width, depth and access to floodplains during large flood events. Field evidence may also suggest a even greater reduction in channel width trajectory, relative to the rural setting, with expansive floodplains to maintain quasi‐equilibrium conditions as bed material supply continues to decrease with increased anthropogenic activity. Copyright © 2010 John Wiley & Sons, Ltd.     

Sex typing and androgyny: further explorations of the expressive domain

Previous research by Bem has indicated that androgynous individuals of both sexes display "masculine" independence when under pressure to conform as well as "feminine" nurturance when interacting with a kitten. In contrast, sex-typed individuals were low in one or both of these behaviors. The two studies reported here were designed to replicate the low nurturance of the masculine male and to clarify the unexpected finding that feminine females were low in both independence and nurturance. In the first study subjects interacted with a human infant, and in the second study they listened to a lonely student. Taken together, the results of these two studies conceptually replicated the low nurturance of the masculine male and demonstrated that the low nurturance of the feminine female does not extend to her interaction with humans. Finally, evidence was presented in support of Spence, Helmreich, and Stapp's distinction between "androgynous" individuals, who are high in both masculinity and feminity, and "undifferentiated" individuals, who are low in both of these characteristics.     

Diversity improvement estimation from rain Radar databases using maximum likelihood estimation

This research examines route diversity as a fade mitigation technique in the presence of rain, for terrestrial microwave links. The improvement in availability due to diversity depends upon the complex spatio-temporal properties of rainfall. To produce a general model to predict the advantage due to route diversity it is necessary to be able to predict the correlation of rain attenuation on arbitrary pairs of microwave links. This is achieved by examination of a database of radar derived rain rate fields. Given a representative sample of rain field images, the joint rain attenuation statistics of arbitrary configurations of terrestrial links can be estimated. Existing rain field databases often yield very small numbers of high joint attenuation events. Consequently, estimates of the probability of joint high attenuation events derived from ratios of the number of occurrences can be highly inaccurate. This paper assumes that pairs of terrestrial microwave links have joint rain attenuation distributions that are bi-lognormally distributed. Four of the five distribution parameters can be estimated from ITU-R models. A maximum likelihood estimation (MLE) method is used to estimate the fifth parameter, i.e., the covariance or correlation. The predicted diversity statistics vary smoothly and yield plausible extrapolations into low probability situations.