致Informix的用户、合作伙伴和股东的一封公开信

今天早晨Informix发表声明,其1997财年第一季度的财政收入将大大低于华尔街的期望。基于初步的信息,第一季度的营业收入大约在1.3～1.45亿美元左右,去年同期的收入为2.04亿美元。这些数字是初步的估计,真正的结果将在4月底公布。 无需多说,我们都对这个结果感到非常失望。Informix执行委员会正在努力寻找营业收入下降的原因,并采取措施使我们的业务状况好转。 我要你们——我们尊敬的用户、合作伙伴和股东,了解所有我们所能提供的在这一季度中产生的问题的性质以及我们相应     

Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism

We present a liquid chromatography/mass spectrometry (LC/MS) method for long-chain and very-long-chain fatty acid analysis and its application to (13)C-tracer studies of fatty acid metabolism. Fatty acids containing 14 to 36 carbon atoms are separated by C(8) reversed-phase chromatography using a water-methanol gradient with tributylamine as ion pairing agent, ionized by electrospray and analyzed by a stand-alone orbitrap mass spectrometer. The median limit of detection is 5 ng/mL with a linear dynamic range of 100-fold. Ratios of unlabeled to (13)C-labeled species are quantitated precisely and accurately (average relative standard deviation 3.2% and deviation from expectation 2.3%). In samples consisting of fatty acids saponified from cultured mammalian cells, 45 species are quantified, with average intraday relative standard deviations for independent biological replicates of 11%. The method enables quantitation of molecular ion peaks for all labeled forms of each fatty acid. Different degrees of (13)C-labeling from glucose and glutamine correspond to fatty acid uptake from media, de novo synthesis, and elongation. To exemplify the utility of the method, we examined isogenic cell lines with and without activated Ras oncogene expression. Ras increases the abundance and alters the labeling patterns of saturated and monounsaturated very-long-chain fatty acids, with the observed pattern consistent with Ras leading to enhanced activity of ELOVL4 or an enzyme with similar catalytic activity. This LC/MS method and associated isotope tracer techniques should be broadly applicable to investigating fatty acid metabolism.     

巴塞罗那Vincci Gala酒店

四星级的Vincci Gala酒店是由位于巴塞罗那扩展区(Eixample)的一栋历史建筑改建而来,酒店拥有78间客房以及酒吧、餐厅、会议室和各式露台.酒店的设计因两个要求而独具特点:一是巴塞罗那古迹保护部(the Monument Protection Department of Barcelona)对于建筑外立面和建筑内部白色大理石楼梯的保护要求;二是酒店要以加拉(Gala,超现实主义画家萨尔瓦多·达利的妻子,他的缪斯的名字)命名的要求.加拉和达利是看似不可能的一对,同样,该项目将新与旧、低调与奢华、优雅与随意这些多重对比调和.作为酒店主色调的金色与有机图形和明暗对比相结合,以不同深浅和应用重复出现在建筑外立面和室内空间中.同时,设计运用大量的金属材料与原建筑所用石材和大理石形成鲜明对比.除了建筑和室内设计,我们还负责灯光、装饰以及标识设计,这使得酒店获得直至细节完整均质的设计.     

阿布扎比Sowwah广场

GP（Goettsch Partners）接受Mubadala发展公司的委托,设计该公司在阿拉伯联合酋长国阿布扎比Sowwah岛上的旗舰商业开发项目——Sowwah广场。项目包含总计约29万m^2的办公空间,特色是被四座办公塔楼所环绕的阿布扎比证券交易所新总部,人们在此可以俯瞰开阔的水面。此外,该项目还整合了2层的零售空间和2个地下停车场。阿布扎比最近出版的《阿布扎比2030规划》的城市规划大纲中,     

潘多拉魔盒都柏林财政部办公楼设计及改建

文章介绍了都柏林格拉夫顿事务所设计的爱尔兰财政部办公楼.设计从城市的角度出发,注重呼应历史遗存和延续建筑传统,同时采用有效的建筑设计策略赋予室内交通和使用空间以新的意义,并给予周围环境积极有效的界面设计.设计创造了一个崭新的政府办公建筑,在延续传统、呼应城市文脉的同时,塑造了办公楼亲切开放民主的建筑形象.     

Theoretical and experimental thermal performance assessment of an innovative external wall insulation system for social housing retrofit

The UK building stock,being amongst the oldest in the developed world,is also one of the least energy efficient and accounts for approximately 45% of UK carbon emission. Energy use from housing alone was responsible for 13% of total UK carbon dioxide and greenhouse gas emissions in 2015. Therefore,achieving the national target of an 80% reduction in carbon emissions by 2050 against 1990 baseline conditions is highly dependent on the reduction of energy consumption in dw ellings. The complexity of the problem of retrofitting energy saving measures in the extensive and diverse aging housing stock is further compounded due to the number of "hard to treat " properties that comprise over 40% of homes in the UK. In this article,the authors present an evaluation of the theoretical and experimental performances of a novel prototype external wall insulation system,developed to improve energy efficiency in "hard to treat"housing. The system was designed to be primarily used to retrofit social housing,w hich comprises up to 18% of the current UK housing stock.A thorough testing regime was undertaken to test the suitability and effectiveness of the new product in the most common social housing construction typologies. This included: an investigation of the theoretical thermal performance of the prototype product through steady state modelling,a laboratory based prototype test,an analysis of empirical data collected from a cross section of social housing properties in Nottinghamshire,UK used to inform whole house dynamic modelling,and the development of dynamic simulations to assess the energy and carbon reduction impacts of the new product. The theoretical modelling suggested that the integration of the system resulted in thermal performance improvements for all construction types with space heating demand reduced by up to 42%. The results of the whole house dynamic modelling assessment also suggested that the addition of the system resulted in a reduction of heating energy demand of up to 49%. The prototyping testing show n that the system is easy to install requirement minimum building skills.The findings suggest that the new product not only meets the performance of existing external wall insulation systems,but also provides unique selling points with respect to easy installation and non-reliance on weather conditions. The project finished with a pilot study when one house was retrofitted using the novel product.     

一些住房及问题

设计师的研究在Mar Azul森林里进行．所以设计师很担心在其已有环境上加上这样一个风格相异的别墅会产生问题．实际情况却是它们融合得很好。一些有特殊要求的别墅业主不断强调要在解决其建筑的审美价值的同时保证别墅的舒适休闲性．维修和建造也要相对较少。这样的要求对于设计师来讲是十分可喜的,但同时也会从中产生很多问题,这也成为了完成每个订单中设计师不断思考的动力。问题的产生本身就是寻找解决方案的起始。