Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

Circular RNAs (circRNAs), a class of new endogenous non-coding RNAs (ncRNAs), are closely related to the carcinogenic process and play a critical role in tumor metastasis. CircRNAs can lay the foundation for tumor metastasis via promoting tumor angiogenesis, make tumor cells gain the ability of migration and invasion by regulating epithelial-mesenchymal transition (EMT), interact with immune cells, cytokines, chemokines, and other non-cellular components in the tumor microenvironment, damage the normal immune function or escape the immunosuppressive network, and further promote cell survival and metastasis. Herein, based on the characteristics and biological functions of circRNA, we elaborated on the effect of circRNA via circRNA-associated competing endogenous RNA (ceRNA) network by acting as miRNA/isomiR sponges on tumor angiogenesis, cancer cell migration and invasion, and interaction with the tumor microenvironment (TME), then explored the potential interactions across different RNAs, and finally discussed the potential clinical value and application as a promising biomarker. These results provide a theoretical basis for the further application of metastasis-related circRNAs in cancer treatment. In summary, we briefly summarize the diverse roles of a circRNA-associated ceRNA network in cancer metastasis and the potential clinical application, especially the interaction of circRNA and miRNA/isomiR, which may complicate the RNA regulatory network and which will contribute to a novel insight into circRNA in the future.     

Sensing mechanism of Ag/α-MoO3 nanobelts for H2S gas sensor

Sensing mechanism is still a big problem in the field of gas sensor.In-depth study of the sensing mecha-nism can provide better ideas for the design of sensing ...     

EDGE网络的规划及资源配置研究

本文在现有网络分析的基础上,进行了EDGE数据网的规划,并通过仿真对规划结果进行了验证,最后对语音和数据网络的资源配置方法进行了研究,提出了相应的资源配置方法。     

奥运火炬大同传递电视转播纪实

为了迎接百年奥运圣火于6月27日的到来,大同电视台要进行全程电视直播．同时,还要协助中央电视台和山西电视台完成起点和终点现场节目录制的联络和信号光纤传输任务,为此,之前的一个月就进行着大量的技术准备工作。由于火炬传递路线几经调整,电视转播的技术方案也随之进行了多次的修改和完善。     

A 20.8-Gbps Dual-Carrier Wireless Communication Link in 220-GHz Band

With the successful demonstration of terahertz (THz) high-speed wireless data transmission,the THz frequencies are now becoming a worth candidate for post-5G wi...     

Characterization,Expression Profiling,and Biochemical Analyses of the Cinnamoyl-CoA Reductase Gene Family for Lignin Synthesis in Alfalfa Plants

Cinnamoyl-CoA reductase (CCR) is a pivotal enzyme in plant lignin synthesis, which has a role in plant secondary cell wall development and environmental stress defense. Alfalfa is a predominant legume forage with excellent quality, but the lignin content negatively affects fodder digestibility. Currently, there is limited information on CCR characteristics, gene expression, and its role in lignin metabolism in alfalfa. In this study, we identified 30 members in the CCR gene family of Medicago sativa. In addition, gene structure, conserved motif, and evolution analysis suggested MsCCR1–7 presumably functioned as CCR, while the 23 MsCCR-likes fell into three categories. The expression patterns of MsCCRs/MsCCR-likes suggested their role in plant development, response to environmental stresses, and phytohormone treatment. These results were consistent with the cis-elements in their promoters. Histochemical staining showed that lignin accumulation gradually deepened with the development, which was consistent with gene expression results. Furthermore, recombinant MsCCR1 and MsCCR-like1 were purified and the kinetic parameters were tested under four substrates. In addition, three-dimensional structure models of MsCCR1 and MsCCR-like1 proteins showed the difference in the substrate-binding motif H212(X)2K215R263. These results will be useful for further application for legume forage quality modification and biofuels industry engineering in the future.     

新的等价类划分算法—计数法

目前,基于基数排序的等价类划分算法有较低的时间复杂度但存在以下不足：属性值跳跃性大时会产生大量空队列;排序后仍需O（|P‖U|）的时间才实现划分,求出等价类,排序没能发挥应有作用。为此,设计了一种新算法,通过属性值映射避免大量空队列产生,通过增加一个记录等价类长度信息的计数数组,排序后仅需O（|U|）就可实现划分,求出等价类。整个算法时间复杂度为O（|C‖U|）,空间复杂度为O（|U|）,为求等价类划分提供了一个新的解决办法。     

ptp通讯在锌电解供电优化系统中的研究与应用

以提高锌电解供电系统的自动化程度、实现网络控制为目的,在分析了系统总体结构和控制原理的基础上,重点讨论了ptp通讯在系统中的研究与应用;ptp通讯网络以S7-300PLC为主站,以两台晶闸管数字触发器为从站,实现电流给定和触发角反馈等信号的传输,其通讯协议简单,开发成本低,与Profibus网一道组成的控制网抗干扰能力强,可靠性高,有力地保证了锌电解供电优化系统安全运行,为锌电解提高整流效率、节约电能提供了保障.     

Kam-Fai Wong, Wenjie Li, Ruifeng Xu and Zheng-sheng Zhang: Introduction to Chinese natural language processing

This is a review of a recent book “Introduction to Chinese Natural Language Processing” by Kam-Fai Wong, Wenjie Li, Ruifeng Xu and Zheng-sheng Zhang. The structure and contents of the book will be briefly described and some comments and observations are presented.     

离散模拟的粒子-边界作用模型

粒子-边界作用模型是粒子模拟中非常重要的一类边界条件,主要包括镜面反射、回弹反射和热边界等.本文详细介绍了这几类边界条件,重点分析讨论了几种模型中涉及的Maxwell分布和偏Maxwell分布以及它们在计算机模拟中的实现方式,并用硬球对流体做了模拟测试.模拟结果表明,对于热平衡状态下的流体,壁面反射粒子速度用Maxwell分布模拟的流体温度比边界要低,二维情况下只有壁面温度的约0.70,三维情况下则约为0.77.并且流体温度不是处处相等,靠近壁面处比其他地方要显得更低,而用偏Maxwell分布模拟的流体状态则与实际情形吻合的很好.