Motion analysis of a tripod parallel mechanism

A tripod parallel mechanism consists of three links of fixed length and a rigid platform, and these are connected by revolute joints. The platform can achieve sixdegrees-of-freedom (6-DOF) motion by the coordinated movement of the bottom ends of the three links on a horizontal plane. This mechanism has advantages over the more common six extendible parallel manipulators. It has a much larger work space and a simple structure. In this article, we show that the vector analysis for this tripod parallel mechanism and the derivation of the positions of the three bottom ends of the links in an arbitrary attitude of platform can be found by inverse kinematics and the conditions of geometrical constraint. Then, by a numerical simulation, the trajectories of the bottom ends of the three links are shown.     

Effects of dressing containing plant sterol on serum cholesterol concentration and the safety evaluation in borderline or mildly hypercholesterolemic Japanese subjects

In a placebo-controlled double-blind study, we examined the effects of dressing containing plant sterol (PS) on blood lipids and the safety in Japanese borderline or mildly hypercholesterolemic subjects. Fifty-nine subjects [total cholesterol (TC) concentration > or = 200 mg/dL] were randomly divided into two groups and were given daily 15 g of dressing containing 800 mg of PS [PS(+)-group] or without PS [PS(-)-group] for 12 weeks. Every 4 weeks, fasting blood was examined and subjective symptoms were analyzed. Serum TC, low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) concentrations did not change in the PS(-)-group, while TC and ApoB significantly decreased in the PS(+)-group at 8 and 12 weeks and LDL-C at 4, 8 and 12 weeks. Moreover, serum TC, LDL-C and ApoB concentrations were significantly lower than those of PS(-)-group at 8 and 12 weeks. Other laboratory tests were all in normal ranges and no adverse events were observed. The results indicated that PS-containing dressing decreased serum TC, LDL-C and ApoB concentrations in borderline or mildly hypercholesterolemic subjects. It is therefore proved that the dressing containing PS is helpful in maintaining blood cholesterol level normal and hence, the health of Japanese.     

Design,Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders

Lysine demethylase 5 C (KDM5C) controls epigenetic gene expression and is attracting great interest in the field of chemical epigenetics. KDM5C has emerged as a therapeutic target for anti-prostate cancer agents, and recently we identified triazole 1 as an inhibitor of KDM5C. Compound 1 exhibited highly potent KDM5C-inhibitory activity in in vitro enzyme assays, but did not show strong anticancer effects. Therefore, a different approach is needed for the development of anticancer agents targeting KDM5C. Here, we attempted to identify KDM5C degraders by focusing on a protein-knockdown strategy. Compound 3 b , which was designed based on compound 1 , degraded KDM5C and inhibited the growth of prostate cancer PC-3 cells more strongly than compound 1 . These findings suggest that KDM5C degraders are more effective as anticancer agents than compounds that only inhibit the catalytic activity of KDM5C.     

Effect of plate position and size for self-induced flow oscillation of underexpanded supersonic jet impinging on perpendicular plate

When the underexpanded supersonic jet impinges on the obstacle, it is well known that the self-induced flow oscillation occurs at the specific condition of the pressure ratio in the flowfield, the position of an obstacle and so on. This oscillation is related with the noise problems of aeronautical and other industrial engineering so that the characteristic and the mechanism of self-induced flow oscillation have to be cleared to control the various noise problems. But, it seems that the characteristics of t...     

Effect of tube bundles on nucleate boiling and critical heat flux

In order to elucidate boiling heat transfer characteristics for each tube and the critical heat flux (CHF) for tube bundles, an experimental investigation of pool and flow boiling of Freon-113 at 0.1 MPa was performed using two typical tube arrangements. A total of fifty heating tubes of 14 mm diameter, equipped with thermocouples and cartridge heaters, were arrayed at pitches of 18.2 and 21.0 mm to simulate both square in-line and equilateral staggered bundles. For the flow boiling tests the same bundles as were used in pool boiling were installed in a vertical rectangular channel, to which the fluid was supplied with an approach velocity varying from 0.022 to 0.22 m/s. It was found in this study that the boiling heat transfer coefficient of each tube in a bundle was higher than that for an isolated single tube in pool boiling. This enhancement increases for tubes at higher locations, but decreases as heat flux is increased. At heat fluxes exceeding certain values, the heat transfer coefficient becomes the same as that for an isolated tube. As the heat flux approaches the CHF, flow pulsations occurred in the pool boiling experiments although the heat transfer coefficient was invariant even under this situation. The approach velocity has an appreciable effect on heat transfer up to a certain level of heat flux. In this range of heat flux, the heat transfer coefficient exceeds the values observed for pool boiling. An additive method with two contributions, i.e., single phase convection and boiling, was used to predict the heat transfer coefficient for bundles. The predicted results showed reasonable agreement with the measured results. The critical heat flux in tube bundles tended to increase as more bubbles were rising through the tube clearance. © 1998 Scripta Technica, Heat Trans Jpn Res, 27(4): 312–325, 1998     

Experimental investigation of falling film evaporation on horizontal tubes

This paper presents the results of an experimental investigation relating to heat transfer during evaporation of thin liquid films falling over horizontal tubes. Experiments were conducted using 25 mm o.d. copper tubes heated by internal electrical cartridge heaters so that a uniform heat flux was generated on the outside tube surface. Five heated tubes were arrayed on a vertical plane with a pitch of 50 mm. Freon R-11 preheated to the saturation temperature at 0.2 MPa was supplied to the topmost heated tube through feeding tubes. Heat transfer characteristics on each heated tube were clarified in a range of film Reynolds number from 10 to 2000 and the measured data are presented in the form of correlations. Deterioration of heat transfer due to film break down was also considered. © 1999 Scripta Technica, Inc. Heat Trans Jpn Res, 27(8): 609–618, 1998     

Characteristics of the Mach Disk in the Underexpanded Jet in which the Back Pressure Continuously Changes with Time

When the high-pressure gas is exhausted to the vacuum chamber from the nozzle, the underexpanded supersonic jet contained with the Mach disk is generally formed. The eventual purpose of this study is to clarify the unsteady phenomenon of the underexpanded free jet when the back pressure continuously changes with time. The characteristic of the Mach disk has been clarified in consideration of the diameter and position of it by the numerical analysis in this paper. The sonic jet of the exit Mach number Me=1 is assumed and the axisymmetric conservational equation is solved by the TVD method in the numerical calculation. The diameter and position of the Mach disk differs with the results of a steady jet and the influence on the continuously changing of the back pressure is evidenced from the comparison with the case of steady supersonic jet.     

Computer-aided design of a factor Xa inhibitor by using MCSS functionality maps and a CAVEAT linker search

We have investigated a new approach to efficiently find a novel inhibitor against a serine protease (i.e. an activated coagulation factor X, FXa) by using de novo design programs and the X-ray crystal structure of the target enzyme. FXa is a coagulant enzyme that generates thrombin (a serine protease) and participates in both intrinsic and extrinsic coagulation pathways. We adopted multiple copy simultaneous search (MCSS) and CAVEAT linker search techniques, which disclosed a novel FXa inhibitor (T01312) consisting of two binding moieties (the benzamidinyl and adamantyl groups) and a linker unit (the carboxybenzylamine group). The inhibitory activity of T01312 against FXa was determined to be a small K(i)-value of 48nM, which is two orders of magnitude smaller than that against thrombin. An X-ray crystal analysis of T01312 complexed with trypsin (an analogue of FXa) and docking studies of T01312 with trypsin and FXa showed that: (i) the benzamidinyl group is a predominant binding moiety in the anionic pocket (S1 site) with an asparatic acid residue; (ii) a hydrophobic pocket (S4 site) is the binding site of the adamantyl group; (iii) the carboxylate group of the linker contributes to the selectivity for FXa against thrombin. Thus, the combination of the knowledge of the X-ray crystal structure of the target molecule with MCSS and CAVEAT linker search techniques proved to be an effective hit-finding method that does not require the screening of huge compound libraries.     

Thick films for multilayer substrates

Abstract

Low temperature fired ceramics based on alumina/glass added oxide ceramics have been developed and are being used by several companies as substrates for high density assembled modular packaging.^1–3 The features of low temperature fireable substrates are the cofireability with highly conductive metals such as Ag, Ag-Pd, or Cu, and the cofireability with other passive component materials for L, C, R and relatively low dielectric constant elements. But most of these substrates have the disadvantage that their thermal expansion coefficient is not perfectly compatible with Si or GaAs. This paper reports the results of a newly developed cordierite/glass based substrate employing Cu as the surface and internal conductors and having the freedom of tuning the thermal expansion coefficient by changing the composition. The ceramic composition with adjustable thermal expansion coefficient value of 3 to 7 ppm/°C can be manufactured and easily matched with the thermal expansion coefficient of Si or GaAs without a big change of electrical performance.     

Required limiting impedance and capacity of fault current limiter installed in customer system with synchronous generator

We investigated the required limiting impedance and capacity of a fault current limiter (FCL) installed at an incoming feeder of a customer system with a synchronous generator in a utility distribution system. It was assumed that two types of FCL were installed, i.e. a resistive type (R‐type) FCL and an inductive type (L‐type) FCL. A fault current out of the customer system and a voltage in the customer system were calculated following a three‐phase, short‐circuit fault occurrence. It was found that the required type of FCL and the required limiting impedance depended on the rated capacity of the generator in order to obtain the suppression of the fault current under 0.1 kA_S and to maintain of customer voltage between 85 and 100% of the nominal voltage (6.6 kV). The capacity of FCL consisting of the smallest limiting impedance is discussed. © 2006 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.