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41.
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A new triazol antifungal agent, (+)-2-(2,4-difluorophenyl)-3-methyl-1-(1H-1, 2,4-triazol-1-yl)-3-[6-(1H-1,2,4-triazol-1-yl)pyridazin++ +-3-ylthio]butan-2-ol (MFB-1041), shows poor oral absorption and is practically insoluble in water (1.2 micrograms/ml). Solid dispersion systems with an enteric polymer such as hydroxypropylmethylcellulose phthalate (HP-55) and carboxymethylethylcellulose (CMEC), and a nonenteric polymer, hydroxypropylmethylcellulose (Metolose) were evaluated to improve drug absorption and solubility. The oral bioavailabilities of these solid dispersions in beagle dogs were over 6 times higher than that of a suspension system with increasing drug solubility in an alkaline medium. X-Ray powder diffraction measurement of the solid dispersion showed a complete drug phase change from a crystal to an amorphous state. Further, from the results of a stability test, the preparations were stable in a desiccated condition and the absorption profiles also showed no change. From the results, it was suggested that the oral administrative preparation of MFB-1041 having a superior absorption profile and a high stability could be obtained by a drug phase change from a crystal to an amorphous state, especially in the spray-drying method using enteric polymers. 相似文献
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针对PTA装置的工艺生产特点,对自动控制系统当中出现的不同种类的问题,进行了多方面的简要探讨与分析,并提出实现安稳运行相应的对策。 相似文献
45.
The oxidation behavior of a Cu60Hf25Ti15 bulk metallic glass was studied over the temperature range of 375–520 °C in dry air. The oxidation kinetics of the amorphous
alloy generally followed the parabolic law at all temperatures, with an oxidation rate increasing with temperature. The oxidation
rates of the amorphous alloy were much higher than those of polycrystalline pure-Cu, implying that the additions of Hf and
Ti accelerated the oxidation reaction. The composition of the scales formed on the amorphous alloy was strongly temperature-dependent,
since they consisted mostly of Cu4O3 and CuO with minor amounts of HfO2 at T ≤ 450 °C, while mostly CuO with minor amounts of HfO2 and Cu2TiO3 were detected at higher temperatures. In addition, nanocrystalline Cu51Hf14 and Cu3Ti2 phases were detected on the substrate after oxidation at T ≥ 450 °C, indicating the occurrence of phase transformation. 相似文献
46.
Kanamaluru S. Ming-Yi Li Kai Chang 《Antennas and Propagation, IEEE Transactions on》1996,44(7):964-974
This paper presents the analysis and design of aperture-coupled microstrip patch antennas and arrays fed by an dielectric image line. A theory based on the cavity model of the microstrip patch antenna and the change in the modal voltage of the image line at the aperture was developed to analyze the single element aperture-coupled microstrip patch antenna. The theory developed was combined with the array theory to design linear traveling wave arrays at X-band and Ka-band frequencies. The required taper in the excitations of the individual patches of the array was achieved by varying the aperture dimensions. Experiments show very good results for the antennas and the arrays 相似文献
47.
In this paper,we address the need for better hands-on learning materials in computing education and the need for integrating mobile computing education into computing curricular.We propose an innovative learning approach that uses state-of-the-art mobile computing technologies and devices to design a highly accessible and real-world relevant hands-on labware for computing education.The labware employs a modular design such that the learning materials can both be combined together into a single course of mobile program development and be integrated into the related computing courses as building blocks.The labware will help students understand the concepts,improve their problem solving skills,and prepare them for the mobile computing industrial workforce.The pilot modules of the labware have been presented to undergraduate students and have received positive feedbacks. 相似文献
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CAE技术在汽轮机高温强度计算中的应用 总被引:1,自引:0,他引:1
为分析某百万千瓦超超临界汽轮机高压缸旋转部件在高温以及高离心力载荷下的强度状况,建立高压缸第一级动叶片的模型.根据蠕变试验数据,采用最小二乘法拟合幂蠕变方程中的各个参数,并详细介绍各参数的拟合、优化和验算过程;用CFD分析软件计算流体域内的对流传热系数并插值到有限元计算程序中,分析叶根倒角处危险区域的蠕变应力状况.数据验算结果表明,利用拟合数据计算得到的蠕变应力值与试验值比较接近,证明该方法可靠;CAE计算结果表明,叶根倒角处危险区域蠕变应力考核合格,并且有充足的安全裕量. 相似文献