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41.
Antisense oligodeoxynucleotides were used to determine whether alterations in the expression of N-methyl-D-aspartate (NMDA) receptor subunit mRNA are responsible for developmental changes in the sensitivity of receptors to agonists and antagonists. Xenopus laevis oocytes were injected with mRNA prepared from neonatal and adult rat cerebral cortex, and the effects of agonists and antagonists were determined under voltage-clamp conditions. Glycine-site antagonists like 7-chlorokynurenate and glutamate-site antagonists like CGP-39653 were more potent at NMDA receptors expressed from mRNA from adult rat cerebral cortex than those expressed from mRNA from 1-day-old rat. NMDA receptors from 1-day-old rat cerebral cortex were more sensitive to activation by glycine than were receptors from adult rat cerebral cortex. 7-Chlorokynurenate and CGP-39653 were more potent inhibitors of responses seen with heteromeric NR1/NR2A receptors than with NR1/ NR2B receptors. Conversely, heteromeric NR1/NR2B receptors were more sensitive to activation by glycine than were NR1/NR2A receptors. We previously described a delay in the expression of the NR2A subunit in developing rat brain. Anti-sense oligodeoxynucleotides were used to determine whether the delayed expression of the NR2A subunit underlies changes in pharmacological properties observed during development. The properties of receptors seen when adult brain mRNA was coinjected with antisense oligodeoxynucleotides against the NR2A subunit were similar to those found in receptors from 1-day-old rat brain. These data suggest that changes in the sensitivity of NMDA receptors to antagonists and to glycine seen during development are a result of alterations in the expression of different species of NR2 subunit mRNA. 相似文献
42.
Summary We consider a circular cylindrical membrane subjected to longitudinal extension and twist. The associated equilibrium deformation is considered to be axisymmetric and the analysis is based on a direct two-dimensional formulation. Wrinkling of the membrane is taken into account in an approximate way by introducing arelaxed strain energy function derived from the neo-Hookean strain energy for isotropic elastic solids. Analytical formulae for wrinkled parts of the membrane are used to corroborate the results of a numerical treatment of the full boundary value problem.Dedicated to the memory of A. C. Pipkin 相似文献
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钟伟明 《石油化工设备技术》2002,23(2):64-66
广州分公司炼油厂重油催化裂化装置四机组轴流风机在 1998年 9月由于入口消音器故障引发重大事故 ,严重影响了装置生产。该文主要针对其损坏的原因、情况和修复方法作了探讨和论述 相似文献
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In order to investigate the galvanic anodic protection (GAP) of ferrous metals (such as 410, 304 and 316 stainless steels) in acid solutions by doped polyaniline (PANi), separate doped PANi powder-pressed electrodes with different surface areas (the area ratio of the PANi electrode to stainless steel is between 1:1 and 1:2) have been prepared. These were coupled with ferrous metal in the following solutions: 5 M sulphuric acid, 5 M phosphoric acid and industrial phosphoric acid (containing 5 M phosphoric acid and 0.05% chloride ion) to construct a galvanic cell, in which PANi is cathode while ferrous metal is anode. The results indicate that a PANi electrode with sufficient area can provide corrosion protection to stainless steel in these acidic solutions. A pilot scale coupling experiment was carried out. The results indicate that PANi is a promising material as an electrode for the anodic protection of ferrous metals in acidic solutions in industrial situations. 相似文献
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双螺杆反应挤出模型的研究 总被引:5,自引:0,他引:5
详细研究了双螺杆中反应挤出聚合物的动力学模型、流动模型和传热模型。通过实验得到了双螺杆反应器中聚合物的停留时间分布及平均停留时间。 相似文献
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非晶软磁合金的巨磁阻抗效应及应用 总被引:3,自引:2,他引:1
近来在FeCoSiB等Co基非晶体丝带中现了巨磁阻抗效应,由于在一小的直流纵向偏置场下该效应能使丝带两端的交流电压发生大而灵敏的变化,因而在磁记录头和传顺技术中具有巨大的应用科学潜能,受到各国学者的关注,本文简单介绍了巨磁阻抗效应的来源,并综述了近年来非晶体软磁合金材料的的巨磁阻抗效应及应用的研究进展,文章最后说明了尚待深入解决的问题。 相似文献