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81.
Physico‐chemical,nutritional, and volatile composition and sensory profile of Spanish jujube (Ziziphus jujuba Mill.) fruits
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Rafa Mazgaj Pawe Lipiski Mateusz Szudzik Aneta Joczy Zuzanna Kope Adrian M. Stankiewicz Marian Kamyczek Dorine Swinkels Beata elazowska Rafa R. Starzyski 《International journal of molecular sciences》2021,22(18)
Iron deficiency is the most common mammalian nutritional disorder. However, among mammalian species iron deficiency anemia (IDA), occurs regularly only in pigs. To cure IDA, piglets are routinely injected with high amounts of iron dextran (FeDex), which can lead to perturbations in iron homeostasis. Here, we evaluate the therapeutic efficacy of non-invasive supplementation with Sucrosomial iron (SI), a highly bioavailable iron supplement preventing IDA in humans and mice and various iron oxide nanoparticles (IONPs). Analysis of red blood cell indices and plasma iron parameters shows that not all iron preparations used in the study efficiently counteracted IDA comparable to FeDex-based supplementation. We found no signs of iron toxicity of any tested iron compounds, as evaluated based on the measurement of several toxicological markers that could indicate the occurrence of oxidative stress or inflammation. Neither SI nor IONPs increased hepcidin expression with alterations in ferroportin (FPN) protein level. Finally, the analysis of the piglet gut microbiota indicates the individual pattern of bacterial diversity across taxonomic levels, independent of the type of supplementation. In light of our results, SI but not IONPs used in the experiment emerges as a promising nutritional iron supplement, with a high potential to correct IDA in piglets. 相似文献
83.
Aneta Sabuszewska-J
wiak Aron Lukaszuk Marta Janicka-Konik Artur Wdowiak Grzegorz Jakiel 《International journal of molecular sciences》2022,23(10)
Endometrial cancer is the most common malignancy of the female genital tract. Obesity is a strong risk factor for endometrial cancer. Adipose tissue is an active endocrine organ that synthesizes biologically active cytokine peptides, called adipokines. Adiponectin and leptin are the main cytokines of adipose tissue, which may influence the development of metabolic diseases and carcinogenesis. In this scenario, we describe the role of leptin and adiponectin in the development of endometrial cancer. A better understanding of the signalling pathway of these cytokines in endometrial cancerogenesis will provide an opportunity for effective target therapy and may be usable in fertility-sparing treatment. In the future, clinical trials focusing on adipokines, molecular biology, and genetics of the tumour will be needed. 相似文献
84.
Freddy Lttekivi Irina Guljavina Getnet Midekessa Janeli Viil Paul R. Heath Rikke Bk Malene Mller Jrgensen Aneta Andronowska Kulli Kingo Alireza Fazeli 《International journal of molecular sciences》2022,23(7)
Psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) are inflammatory diseases with unresolved pathophysiological aspects. Extracellular vesicles (EVs) play an important role in intercellular communication. We compared the miRNA contents and surface proteome of the EVs in the blood serum of PsV and PsA patients to healthy controls. Size-exclusion chromatography was used to isolate EVs from the blood serum of 12 PsV patients, 12 PsA patients and 12 healthy control subjects. EV samples were characterized and RNA sequencing was used to identify differentially enriched EV-bound miRNAs. We found 212 differentially enriched EV-bound miRNAs present in both PsV and PsA groups—a total of 13 miRNAs at FDR ≤ 0.05. The predicted target genes of these miRNAs were significantly related to lesser known but potentially disease-relevant pathways. The EV array revealed that PsV patient EV samples were significantly enriched with CD9 EV-marker compared to controls. Analysis of EV-bound miRNAs suggests that signaling via EVs in the blood serum could play a role in the pathophysiological processes of PsV and PsA. EVs may be able to fill the void in clinically applicable diagnostic and prognostic biomarkers for PsV and PsA. 相似文献
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Paula Wrblewska-uczka Justyna Cabaj Weronika Bk Julia Bargie Aneta Grabarska Agnieszka Gralczyk Jarogniew J. uszczki 《International journal of molecular sciences》2022,23(17)
The incidence of melanoma is steadily increasing worldwide. Melanoma is the most lethal skin cancer, and new therapeutic methods are being sought. Our research aimed to investigate the cytotoxic and antiproliferative effects of betulinic acid in vitro, used alone and in combination with taxanes (paclitaxel, docetaxel) in four melanoma cell lines. Isobolographic analysis allowed us to assess the interactions between these compounds. Betulinic acid had no cytotoxic effect on normal human keratinocyte HaCaT cells; the amount of LDH released by them was significantly lower compared to melanoma cell lines. The present study shows that betulinic acid significantly inhibits the growth of melanoma cell lines in vitro. The IC50 values of betulinic acid ranged from 2.21 µM to 15.94 µM against the four melanoma lines. Co-treatment of betulinic acid with paclitaxel or docetaxel generated desirable drug–drug interactions, such as an additive and additive with a tendency to synergy interactions. 相似文献
87.
Andrzej Komorek Zenon Komorek Aneta Krzyzak Pawel Przybylek Robert Szczepaniak 《International Journal of Thermophysics》2017,38(8):128
In the article, the authors describe the analysis of the impact of the frequency of fatigue tests on the temperature of the modified polymer. The base material for producing the samples was the epoxy resin Epidian 57 cured with Z1 hardener. The presented study is part of a research program of adhesive joints made with the composition Epidian 57/Z1 aiming to determine the effect of physical modification of the adhesive composition on its properties and on the properties of adhesive joints made with such a modified composition. The tested adhesive compositions were modified by additions of micro- and nanoparticles in an amount of 1.85 % (micro- and nanoparticles) or 10 % (microparticles) in weight, depending on the type of the particles. In the studies, the authors used the particles of tungsten, microspheres and carbon nanotubes. The polymer samples produced by casting were loaded with compressive identical, one-sided loads at two different frequencies of load changes. During the tests, the authors recorded the temperature changes as a function of the number of cycles. The changes in the temperature field on the surface of the samples during the tests were observed by the infrared camera. As a result of the studies, it was possible to observe a significant impact of the composition of the polymer and the frequency of load changes during the test on the temperature of the sample. 相似文献
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89.
Johannes Kahl Farnaz Alborzi Alexander Beck Susanne Bügel Nicolaas Busscher Uwe Geier Darja Matt Tabea Meischner Flavio Paoletti Sirli Pehme Angelika Ploeger Ewa Rembiałkowska Otto Schmid Carola Strassner Bruno Taupier‐Letage Aneta Załęcka 《Journal of the science of food and agriculture》2014,94(13):2582-2594
In 2007 EU Regulation (EC) 834/2007 introduced principles and criteria for organic food processing. These regulations have been analysed and discussed in several scientific publications and research project reports. Recently, organic food quality was described by principles, aspects and criteria. These principles from organic agriculture were verified and adapted for organic food processing. Different levels for evaluation were suggested. In another document, underlying paradigms and consumer perception of organic food were reviewed against functional food, resulting in identifying integral product identity as the underlying paradigm and a holistic quality view connected to naturalness as consumers' perception of organic food quality. In a European study, the quality concept was applied to the organic food chain, resulting in a problem, namely that clear principles and related criteria were missing to evaluate processing methods. Therefore the goal of this paper is to describe and discuss the topic of organic food processing to make it operational. A conceptual background for organic food processing is given by verifying the underlying paradigms and principles of organic farming and organic food as well as on organic processing. The proposed definition connects organic processing to related systems such as minimal, sustainable and careful, gentle processing, and describes clear principles and related criteria. Based on food examples, such as milk with different heat treatments, the concept and definitions were verified. Organic processing can be defined by clear paradigms and principles and evaluated according criteria from a multidimensional approach. Further work has to be done on developing indicators and parameters for assessment of organic food quality. © 2013 Society of Chemical Industry 相似文献
90.