University institutional repositories: competitive environment and their role as communication media of scientific knowledge

Are institutional repositories mere warehouses for digital documents or are they in fact establishing themselves as a rigorous option for the spread of scientific knowledge? This study analyses the competitive environment of the Top100 university repositories, defined as leaders in terms of market participation and penetration. The study also analyses the basic functionalities of preservation and diffusion of academic production through factors related to the prestige of the repositories and of the institutions that operate them. The results show that repositories with a larger digital academic supply are associated with the production of demonstrated scientific rigor.     

Power bus isolation using power islands in printed circuit boards

Power islands are often employed in printed circuit board (PCB) designs to alleviate the problem of power bus noise coupling between circuits. Good isolation can be obtained over a wide frequency band due to the large series impedance provided by the gap between the power islands. However, power bus resonances may degrade the isolation at high frequencies. The amount of isolation also depends on the type of connection between power islands and the components on the board. This paper experimentally investigates the effectiveness of several power island structures up to 3.0 GHz     

Quantification of the Immune Content in Neuroblastoma: Deep Learning and Topological Data Analysis in Digital Pathology

We introduce here a novel machine learning (ML) framework to address the issue of the quantitative assessment of the immune content in neuroblastoma (NB) specimens. First, the EUNet, a U-Net with an EfficientNet encoder, is trained to detect lymphocytes on tissue digital slides stained with the CD3 T-cell marker. The training set consists of 3782 images extracted from an original collection of 54 whole slide images (WSIs), manually annotated for a total of 73,751 lymphocytes. Resampling strategies, data augmentation, and transfer learning approaches are adopted to warrant reproducibility and to reduce the risk of overfitting and selection bias. Topological data analysis (TDA) is then used to define activation maps from different layers of the neural network at different stages of the training process, described by persistence diagrams (PD) and Betti curves. TDA is further integrated with the uniform manifold approximation and projection (UMAP) dimensionality reduction and the hierarchical density-based spatial clustering of applications with noise (HDBSCAN) algorithm for clustering, by the deep features, the relevant subgroups and structures, across different levels of the neural network. Finally, the recent TwoNN approach is leveraged to study the variation of the intrinsic dimensionality of the U-Net model. As the main task, the proposed pipeline is employed to evaluate the density of lymphocytes over the whole tissue area of the WSIs. The model achieves good results with mean absolute error 3.1 on test set, showing significant agreement between densities estimated by our EUNet model and by trained pathologists, thus indicating the potentialities of a promising new strategy in the quantification of the immune content in NB specimens. Moreover, the UMAP algorithm unveiled interesting patterns compatible with pathological characteristics, also highlighting novel insights into the dynamics of the intrinsic dataset dimensionality at different stages of the training process. All the experiments were run on the Microsoft Azure cloud platform.     

A bibliometric portrait of the evolution, scientific roots and influence of the literature on university–industry links

The study of university?Cindustry (U?CI) relations has been the focus of growing interest in the literature. However, to date, a quantitative overview of the existing literature in this field has yet to be accomplished. This study intends to fill this gap through the use of bibliometric techniques. By using three different yet interrelated databases??a database containing the articles published on U?CI links, which encompass 534 articles published between 1986 and 2011; a ??roots?? database, which encompasses over 20,000 references to the articles published on U?CI relations; and a ??influences?? database which includes more than 15,000 studies that cited the articles published on U?CI relations??we obtained the following results: (1) ??Academic spin offs??, ??Scientific and technological policies?? and (to a greater extent) ??Knowledge Transfer Channels?? are topics in decline; (2) ??Characteristics of universities, firms and scientists??, along with ??Regional spillovers??, show remarkable growth, and ??Measures and indicators?? can be considered an emergent topic; (3) clear tendency towards ??empirical?? works, although ??appreciative and empirical?? papers constitute the bulk of this literature; (4) the multidisciplinary nature of the intellectual roots of the U?CI literature??an interesting blending of neoclassical economics (focused on licensing, knowledge transfer and high-tech entrepreneurship) and heterodox approaches (mainly related to systems of innovation) is observed in terms of intellectual roots; (5) the influence of the U?CI literature is largely concentrated on the industrialized world and on the research area of innovation and technology (i.e., some ??scientific endogamy?? is observed).     

Improved photovoltaic performances by post-deposition acidic treatments on tetrapod shaped colloidal nanocrystal solids

The ligand exchange reaction with pyridine is the standard procedure for the integration of colloidal semiconductor nanocrystals (NCs) in photovoltaic devices; however, for large sized and irregularly shaped branched NCs, such as CdSe@CdTe tetrapods, this procedure can lead to a considerable waste of materials and the aggregation of NCs in the colloidal solution, therefore resulting in the formation of an inhomogeneous film and low device performances. Here, we report on alternative post-deposition treatments with carboxylic acids on films of CdSe@CdTe tetrapod shaped NCs. This approach guarantees the removal of the insulating surfactant, necessary to obtain good charge transport among NCs, while preserving the film integrity. We perform a complete characterization of the nanocrystalline films treated with different carboxylic acids and demonstrate the successful integration of such films in photovoltaic devices, showing a doubled efficiency with respect to the standard ligand exchange procedure. Our approach represents a general route towards the development of NC based devices with improved performances and minimized waste of material.     

Analytical study of apple liqueurs

In the present work the composition of apple liqueurs has been analysed, since the consumption of these beverages in Spain has increased during the last years. Twenty-five samples, belonging to the most representative five brands of the Spanish market have been analysed. The following determinations were carried out: alcoholic grade, total acidity, methanol, furfurol, dry extract, reducing sugars, sucrose, ash contact, macroelements (Na, K, Ca, Mg) and microelements (Cu, Fe, Mn, Zn). These parameters enable the quality evaluation of these beverages and contribute to their characterization with respect to the fruit used in their elaboration. To complete the experimental study, a BMDP 7M discriminant statistical analysis has been applied to the results obtained. The variables that best discriminate the groups have been determined and all the samples have been classified and differentiated.

---

Analytisches Studium der Apfelsaftliköre

Zusammenfassung Es wurde die Zusammensetzung von Apfelsaftlikören analysiert, weil diese Getränke öfter in Spanien getrunken werden. Fünfundzwanzig Proben von fünf bestimmten, spanischen Markengetränken wurden analysiert. Es wurden folgende Bestimmungen ausgeführt: Alkoholkonzentration, Gehalt an Säure, Methanol, Extrakt, Zucker, Sucrose, Asche, Macroelemente (Na, K, Ca, Mg) und Mikroelemente (Cu, Fe, Mn, Zn). Diese Parameter erlauben die Qualität dieser Getränke zu schätzen und ihre Charakterisierung auf Grund des Fruchtgehaltes. Weiterhin wurde eine BMDP 7M diskriminant-statistische Analyse der Resultate angewandt. Die diskriminant-Variablen der Gruppe wurden bestimmt und alle Proben konnten klassifiziert und unterschieden werden.

     

Visible spectroelectrochemical characterization of Geobacter sulfurreducens biofilms on optically transparent indium tin oxide electrode

We report visible spectroelectrochemical (SEC) characterization of cytochrome c₅₅₂ (cyt c₅₅₂) in viable Geobacter sulfurreducens biofilms on tin-doped indium oxide (ITO) electrodes poised at 0.24 V vs. SHE. G. sulfurreducens biofilms were grown in minimal medium with acetate as electron donor (turnover conditions), followed by 24 h incubation in electron donor-depleted medium (non-turnover conditions). The electronic absorption spectra of G. sulfurreducens biofilms showed the lowest energy absorption band in the reduced state at 552 nm, which indicated excess of cyt c₅₅₂ in the biofilm. The spectra under non-turnover conditions displayed gradual reduction of the cyt c₅₅₂, following the step-wise decrease of electrode potential from 0.0 V to −0.6 V vs. standard calomel electrode (SCE). The spectral changes were fully reversible in both positive and negative direction of the scan potential, with average midpoint potential value of −0.42 V vs. SCE. Confocal microscopy analysis revealed that the thickness of biofilms under turnover conditions and non-turnover conditions was approximately 35 and 3.5 μm, respectively. This is the first study to observe the reversible redox conversion of cyt c₅₅₂ in viable G. sulfurreducens biofilms.     

Quantifying SMT decoupling capacitor placement in dc power-busdesign for multilayer PCBs

Noise on a dc power-bus that results from device switching, as well as other potential mechanisms, is a primary source of many signal integrity (SI) and electromagnetic interference (EMI) problems. Surface mount technology (SMT) decoupling capacitors are commonly used to mitigate this power-bus noise. A critical design issue associated with this common practice in high-speed digital designs is placement of the capacitors with respect to the integrated circuits (ICs). Local decoupling, namely, placing SMT capacitors in proximity to ICs, is investigated in this study. Multilayer PCB designs that employ entire layers or area fills for power and ground in a parallel plate structure are considered. The results demonstrate that local decoupling can provide high-frequency benefits for certain PCB geometries through mutual inductive coupling between closely spaced vias. The associated magnetic flux linkage is between the power and ground layers. Numerical modeling using an integral equation formulation with circuit extraction is used to quantify the local decoupling phenomenon. Local decoupling can effectively reduce high-frequency power-bus noise, though placing capacitors adjacent to ICs may limit routing flexibility, and tradeoffs need to be made based on design requirements. Design curves are generated as a function of power-bus layer thickness and SMT capacitor/IC spacing using the modeling approach to quantify the power-bus noise reduction for decoupling capacitors located adjacent to devices. Measurement data is provided to corroborate the modeling approach