The Protosphera Experiment and the PROTO-PINCH Testbench

Spherical Tori A=R/α<2 were originally proposed by M. Peng and his collaborators at ORNL. They are based on economical (low aspect ratio=low volume=low cost) and physical (probable no disruptions, low geodesic curvature,     

蛋白质组学面临的新问题

蛋白质组学领域仅仅经历了十年的发展历程。虽然它还有许多棘手的问题尚待解决，但是研究人员坚信蛋白质组学能够发现新的药靶和生物标记物，从而可以改进诊断和治疗过程。本文选择此领域内几家瑞士公司的工作进行评述。     

改善“最终形状成形”的经济性

改善“最终形状成形”的经济性美国国民机械公司ＲｏｂｅｒｔＪ．ＳｃｈｉｌｉｎｇＷｉｌｉａｍＲ．Ｐｅｒｒｙ１“接近最终形状成形”的优越性利用多模递进式成形机由金属盘料来冷锻生产零件已被广泛接受。这种加工与切削、铸造或锻造等相比较具有下列明显的优点：①降低...     

Contribution of extracellular polymeric substances from Shewanella sp. HRCR-1 biofilms to U(VI) immobilization

The goal of this study was to quantify the contribution of extracellular polymeric substances (EPS) to U(VI) immobilization by Shewanella sp. HRCR-1. Through comparison of U(VI) immobilization using cells with bound EPS (bEPS) and cells with minimal EPS, we show that (i) bEPS from Shewanella sp. HRCR-1 biofilms contribute significantly to U(VI) immobilization, especially at low initial U(VI) concentrations, through both sorption and reduction; (ii) bEPS can be considered a functional extension of the cells for U(VI) immobilization and they likely play more important roles at lower initial U(VI) concentrations; and (iii) the U(VI) reduction efficiency is dependent upon the initial U(VI) concentration and decreases at lower concentrations. To quantify the relative contributions of sorption and reduction to U(VI) immobilization by EPS fractions, we isolated loosely associated EPS (laEPS) and bEPS from Shewanella sp. HRCR-1 biofilms grown in a hollow fiber membrane biofilm reactor and tested their reactivity with U(VI). We found that, when reduced, the isolated cell-free EPS fractions could reduce U(VI). Polysaccharides in the EPS likely contributed to U(VI) sorption and dominated the reactivity of laEPS, while redox active components (e.g., outer membrane c-type cytochromes), especially in bEPS, possibly facilitated U(VI) reduction.     

Predicting the function and subcellular location of Caenorhabditis elegans proteins similar to Saccharomyces cerevisiae beta-oxidation enzymes

The role of peroxisomal processes in the maintenance of neurons has not been thoroughly investigated. We propose using Caenorhabditis elegans as a model organism for studying the molecular basis underlying neurodegeneration in certain human peroxisomal disorders, e.g. Zellweger syndrome, since the nematode neural network is well characterized and relatively simple in function. Here we have identified C. elegans PEX-5 (C34C6.6) representing the receptor for peroxisomal targeting signal type 1 (PTS1), defective in patients with such disorders. PEX-5 interacted strongly in a two-hybrid assay with Gal4p-SKL, and a screen using PEX-5 identified interaction partners that were predominantly terminated with PTS1 or its variants. A list of C. elegans proteins with similarities to well-characterized yeast beta-oxidation enzymes was compiled by homology probing. The possible subcellular localization of these orthologues was predicted using an algorithm based on trafficking signals. Examining the C termini of selected nematode proteins for PTS1 function substantiated predictions made regarding the proteins' peroxisomal location. It is concluded that the eukaryotic PEX5-dependent route for importing PTS1-containing proteins into peroxisomes is conserved in nematodes. C. elegans might emerge as an attractive model system for studying the importance of peroxisomes and affiliated processes in neurodegeneration, and also for studying a beta-oxidation process that is potentially compartmentalized in both mitochondria and peroxisomes.     

气井的动态优化技术

在生产层特别是在致密含气砂岩中合理放置支撑剂是产量优化成功的关键。几十年来，油气行业一直采用同位素作为支撑剂标记来帮助确定支撑剂放置的是否成功。一般是在压裂的不同阶段加入放射性示踪剂，以帮助评价支撑剂放置在各目的层的放置情况。     

巴西远海深水开发面临挑战

2000年,壳牌在离巴NEspirito Santo 60英里进行钻探,发现了北Campos盆地BC10区块的6个油田。随后展开了大规模的勘探和评估项目,包括钻探了13口井以及为商业研究投入工程师和先前费用。在该区块发现的六个油田中,已经有四个在2005年12月被宣布存在商业开采价值。与官方期望一致,这一地区被命名为“Parquede Conchas”（壳牌公园）,个别的油田以海贝命名。他们是：Ostra（Oyster）,Abalone,Argonauta and Nautilus。     

Ultrasensitive aptamer-based multiplexed electrochemical detection by coupling distinguishable signal tags with catalytic recycling of DNase I

This work reports an aptamer-based, disposable, and multiplexed sensing platform for simultaneous electrochemical determination of small molecules, employing adenosine triphosphate (ATP) and cocaine as the model target analytes. The multiplexed sensing strategy is based on target-induced release of distinguishable redox tag-conjugated aptamers from a magnetic graphene platform. The electronic signal of the aptasensors could be further amplified by coupling DNase I with catalytic recycling of self-produced reactants. The assay was based on the change in the current at the various peak potentials in the presence of the corresponding signal tags. Experimental results revealed that the multiplexed electrochemical aptasensor enabled the simultaneous monitoring of ATP and cocaine in a single run with wide working ranges and low detection limits (LODs: 0.1 pM for ATP and 1.5 pM for cocaine). This concept offers promise for rapid, simple, and cost-effective analysis of biological samples.     

应用灵活的解决方案进行毫米波测量

在30至300GHz之间,毫米波测量的应用正在增加。从高数据速率到汽车行业再到射电天文学,灵活的测量解决方案正日益显现出它的优势。在这些应用中,毫米波测量解决方案必须遵守很多规则。例如,探测环境中的晶圆器件表征,或通过波导或同轴接口进行模块测试。解决方案还包括夹具中或自由空间的材料测量,或室外／室内天线测试。[第一段]