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排序方式: 共有854条查询结果,搜索用时 15 毫秒
91.
Study of the modulus of elasticity of polymer concrete compounds and comparative assessment of polymer concrete and portland cement concrete 总被引:1,自引:0,他引:1
The main aim of this study is to assess the modulus of elasticity of polymer concrete (PC) compounds produced using two types of binders: orthophtalic or isophtalic polyester. The compositions used were selected from a previous study that identified cost-effective PC compositions. Based on those data, the concentrations of polymer used were 12% of orthophtalic polyester and 13% of isophtalic polyester by weight of the dry materials. Fly ash was used as a filler and compositions with 8%, 12%, 16% and 20% of ash by weight of aggregate were studied. Results indicate that all compositions assessed in this study display high modulus of elasticity values. Statistical analysis of the data reveals that the type of resin and the concentration of fly ash, both in isolation and in combination, have a significant effect on the modulus of elasticity of these compounds. 相似文献
92.
Zelazo Philip David; Reznick J. Steven; Pi?on Denise E. 《Canadian Metallurgical Quarterly》1995,31(3):508
Two-year-olds' difficulty with rule execution is robust and pervasive. In Experiment 1, 120 32-month-olds received 1 of 6 tasks: a task assessing knowledge about a series of items; a deductive card sort requiring children to use their knowledge to sort the items by rules; and 4 modifications of the card sort that provided various types of task support. Children performed better on the knowledge task than the other tasks, which did not differ. Errors increased over trials and were typically perseverative. Experiment 2 replicated the finding that children failed to use rules systematically even when items were labeled by the rules' antecedents. Improvements in rule use seem to reflect emerging control over actions rather than increased representational flexibility. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
93.
Denise C. Hunter Jingli Zhang Lesley M. Stevenson Margot A. Skinner 《International Journal of Food Science & Technology》2008,43(12):2123-2129
Developing functional food products requires a structured approach for screening potential ingredients. Using the development of a product with antioxidant properties as a model, eight fruit juice concentrates were screened, including New Zealand fruits. The total phenolic content and the antioxidant capacity, using chemical‐based assays (ferric reducing antioxidant power and oxygen radical absorbance capacity assays), were determined. The potential to protect against oxidative stress in Jurkat cells was also determined. Results indicate that the total phenolic content and antioxidant capacity in chemical‐based assays were strongly correlated. However, the total phenolic content did not dictate the level of protection from oxidative stress in this cell‐based model, suggesting that the type of phenolic compounds present and interactions between them may be important, although the activity of other compounds, such as vitamin C or carotenoids, may also be implicated. This model for screening ingredients may be used to design synergistic combinations of ingredients, and results may provide supportive evidence in the development of functional foods for this and other health targets. 相似文献
94.
Alan M. Allgeier Denise Andersen Michael D. Bartberger Emilio E. Bunel Robert D. Larsen Pingli Liu Thomas Storz Jason S. Tedrow 《Topics in Catalysis》2014,57(17-20):1335-1341
To overcome stability issues associated with the use of an aldehyde in a catalytic reductive amination reaction, a cyclic ketolactol (ω-hydroxylactone) was employed as an aldehyde surrogate to form a γ-aminoacid. The reaction proceeded most favorably over a Pt/C catalyst. The thermodynamics of each step were evaluated using density functional theory calculations, which correctly predicted the dominance of the ring-closed lactol reactant, yet suggested a preference for a ring-opened iminium intermediate upon the initial, slightly endoergic addition of amine substrate. Exoergic hydrogenation of this intermediate provided the thermodynamic driving force for the overall transformation. During development, the reaction was observed to depend significantly on the volumetric gas to liquid mass transfer coefficient (kLa) and this parameter was optimized to ensure successful scale up in a 400 L stirred tank reactor. 相似文献
95.
Unique Crystal Structure of a Novel Surfactant Protein from the Foam Nest of the Frog Leptodactylus vastus
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Dr. Denise Cavalcante Hissa Dr. Gustavo Arruda Bezerra Dr. Ruth Birner‐Gruenberger Dr. Luciano Paulino Silva Dr. Isabel Usón Prof. Dr. Karl Gruber Prof. Dr. Vânia Maria Maciel Melo 《Chembiochem : a European journal of chemical biology》2014,15(3):393-398
Breeding by releasing eggs into stable biofoams (“foam nests”) is a peculiar reproduction mode within anurans, fish, and tunicates; not much is known regarding the biochemistry or molecular mechanisms involved. Lv‐ranaspumin (Lv‐RSN‐1) is the predominant protein from the foam nest of the frog Leptodactylus vastus. This protein shows natural surfactant activity, which is assumed to be crucial for stabilizing foam nests. We elucidated the amino acid sequence of Lv‐RSN‐1 by de novo sequencing with mass‐spectrometry and determined the high‐resolution X‐ray structure of the protein. It has a unique fold mainly composed of a bundle of 11 α‐helices and two small antiparallel β‐strands. Lv‐RSN‐1 has a surface rich in hydrophilic residues and a lipophilic cavity in the region of the antiparallel β‐sheet. It possesses intrinsic surface‐active properties, reducing the surface tension of water from 73 to 61 mN m?1 (15 μg mL?1). Lv‐RSN‐1 belongs to a new class of surfactants proteins for which little has been reported regarding structure or function. 相似文献
96.
Coussy S Benzaazoua M Blanc D Moszkowicz P Bussière B 《Journal of hazardous materials》2011,185(2-3):1467-1476
Arsenic (As) is a toxicant in tailings from sulphur deposits. It represents an environmental risk because of its high solubility. Tailings can be mixed with water (typically 25%) and a low proportion of hydraulic binder (3-7%) to produce a cemented paste backfill (CPB), stored in underground mine openings. CPB is a tailings storage technique, but it could also provide environmental advantages by stabilization of polluting elements such as As. Tailings from Casa Berardi mine (QC, Canada) contain As (3800 ppm), mainly in arsenopyrite form. For this study, three different CPBs were synthesized in laboratory using Casa Berardi tailings and three different binders. These pastes were submitted to various leaching tests after 28 days of curing. The results indicate that As is released at higher concentration for a fly ash-based CPB than for slag- and Portland cement-based CPB. However, at lower pH, As is better stabilized in fly ash-based samples. These differences can be explained by a variation of solubility of As-compounds in each CPB. Several mechanisms of As release occur, as diffusion and/or dissolution/precipitation. The accelerated weathering test results show that sulphide reactivity is buffered by the neutralizing minerals contained in CPB, and influence the As release behaviour by decreasing the oxidation of As-bearing sulphides. 相似文献
97.
The effectiveness of ozone and acidulant treatments in extending the refrigerated shelf life of fresh-cut potatoes 总被引:1,自引:0,他引:1
Calder BL Skonberg DI Davis-Dentici K Hughes BH Bolton JC 《Journal of food science》2011,76(8):S492-S498
Abstract: The objective of the study was to determine the effectiveness of acidulant dip treatments (with or without aqueous ozone) to reduce enzymatic browning and to extend the shelf life of fresh‐cut potato slices during refrigerated storage (4 °C) for 28 d. Potato slices subjected to aqueous ozone (2 ppm) had significantly (P≤ 0.05) higher L‐values and lower a‐values, but ozone did not appear to have any effect on aerobic plate counts (APCs) or polyphenol oxidase (PPO) activity. NatureSeal (NS) and sodium acid sulfate (SAS) were the most effective acidulant treatments in reducing browning (significantly [P≤ 0.05] higher L‐values, lower a‐values, and browning index values) regardless of ozone treatment. NS and SAS also had lower PPO activity compared to other treatments on days 0 and 28, and significantly (P≤ 0.05) lower APCs (≤2.00 log CFU/g) over refrigerated storage. Therefore, the SAS treatment was comparable to NS, a commercially available product, and showed promise as an effective antibrowning dip to reduce browning and spoilage in fresh‐cut potato products. Practical Application: A 1% SAS dip treatment which included 1% citric and 1% ascorbic acid was found to be an effective antibrowning dip for fresh‐cut potatoes along with NatureSeal®'s PS‐10, compared to other treatments. They were both effective in maintaining low microbial counts over refrigerated storage. Additionally, aqueous ozone washes (2 ppm) showed significant benefits to reduce browning; however, ozone did not affect microbial counts or PPO enzyme activity. Therefore, the SAS treatment could have potential use in the fruit and vegetable industry to reduce browning and spoilage in fresh‐cut potato products. 相似文献
98.
Natlia Lins da Silva-Gomes Leonardo Alexandre de Souza Ruivo Claudia Moreira Marcelo Meuser-Batista Cristiane Frana da Silva Denise da Gama Jaen Batista Stênio Fragoso Gabriel Melo de Oliveira Maria de Nazar Correia Soeiro Otacilio C. Moreira 《International journal of molecular sciences》2022,23(23)
Ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) are enzymes located on the surface of the T. cruzi plasma membrane, which hydrolyze a wide range of tri-/-diphosphate nucleosides. In this work, we used previously developed genetically modified strains of Trypanosoma cruzi (T. cruzi), hemi-knockout (KO +/−) and overexpressing (OE) the TcNTPDase-1 gene to evaluate the parasite infectivity profile in a mouse model of acute infection (n = 6 mice per group). Our results showed significantly higher parasitemia and mortality, and lower weight in animals infected with parasites OE TcNTPDase-1, as compared to the infection with the wild type (WT) parasites. On the other hand, animals infected with (KO +/−) parasites showed no mortality during the 30-day trial and mouse weight was more similar to the non-infected (NI) animals. In addition, they had low parasitemia (45.7 times lower) when compared with parasites overexpressing TcNTPDase-1 from the hemi-knockout (OE KO +/−) group. The hearts of animals infected with the OE KO +/− and OE parasites showed significantly larger regions of cardiac inflammation than those infected with the WT parasites (p < 0.001). Only animals infected with KO +/− did not show individual electrocardiographic changes during the period of experimentation. Together, our results expand the knowledge on the role of NTPDases in T. cruzi infectivity, reenforcing the potential of this enzyme as a chemotherapy target to treat Chagas disease (CD). 相似文献
99.
Sonia Domingos-Pereira Karthik Sathiyanadan Lenka Polak Jacques-Antoine Haefliger Martina Schmittnaegel Carola H. Ries Patrice Jichlinski Beat Roth Laurent Derr Denise Nardelli-Haefliger 《International journal of molecular sciences》2023,24(1)
Bacillus Calmette-Guérin (BCG) instillations for the treatment of non-muscle-invasive bladder cancer patients can result in significant side effects and treatment failure. Immune checkpoint blockade and/or decreasing tumor-infiltrating myeloid suppressor cells may be alternative or complementary treatments. Here, we have characterized immune cell infiltration and chemoattractant molecules in mouse orthotopic MB49 bladder tumors. Our data show a 100-fold increase in CD45+ immune cells from day 5 to day 9 tumors including T cells and mainly myeloid cells. Both monocytic myeloid-derived suppressor-cells (M-MDSC) and polymorphonuclear (PMN)-MDSC were strongly increased in day 9 tumors, with PMN-MDSC representing ca. 70% of the myeloid cells in day 12 tumors, while tumor associated macrophages (TAM) were only modestly increased. The kinetic of PD-L1 tumor expression correlated with published data from patients with PD-L1 expressing bladder tumors and with efficacy of anti-PD-1 treatment, further validating the orthotopic MB49 bladder-tumor model as suitable for designing novel therapeutic strategies. Comparison of chemoattractants expression during MB49 bladder tumors grow highlighted CCL8 and CCL12 (CCR2-ligands), CCL9 and CCL6 (CCR-1-ligands), CXCL2 and CXCL5 (CXCR2-ligands), CXCL12 (CXCR4-ligand) and antagonist of C5/C5a as potential targets to decrease myeloid suppressive cells. Data obtained with a single CCR2 inhibitor however showed that the complex chemokine crosstalk would require targeting multiple chemokines for anti-tumor efficacy. 相似文献
100.
Jonathan Tenrio Vinhal Raquel Húngaro Costa Jorge Luís Coleti Denise C. R. Espinosa 《加拿大化工杂志》2021,99(1):166-177
The volume of tailings produced by the extractive industry has been increasing due to the processing of the low‐grade ore. This issue can cause environmental accidents and require significant investment to control the disposal of tailings. Therefore, this study aims to recover iron from zinc mine tailings by wet magnetic separation followed by the carbothermal reduction of self‐reducing briquettes. Two magnetic separation routes were investigated to concentrate iron. Zinc mine tailings were processed by route I, in a rougher stage followed by a scavenger stage; and route II, in a rougher stage followed by a cleaner stage. The carbothermal reductions were performed using self‐reducing briquettes composed of Fe concentrate from the route with high Fe content and charcoal. The products were analyzed by scanning electron microscopy with energy dispersive spectroscopy (SEM‐EDS), x‐ray diffraction (XRD), inductively coupled plasma optical emission spectrometry (ICP‐OES), and volumetric chemical analysis. Magnetic separation route II provided the highest‐grade Fe concentrate, 52% Fe, while route I provided 33% Fe. In the carbothermal reductions, a metallization degree of 98% in the Fe concentrate briquette, 97% in the briquette with a 10% replacement of its raw material by Fe concentrate, and 99% in the hematite briquette was reached. The replacement of raw material by Fe concentrate showed no significant change in Fe recovery. Considering the whole process, magnetic separation and carbothermal reduction, the recovery of Fe from the zinc mine tailings was 67%. Therefore, the process route suggested in this study will not only reduce tailings disposal and consequently the risk of environmental accidents, but it will also provide profitable raw material for the steel industry. 相似文献