Suppressive effect of corticosteroids on the gene expression of interleukin-5 and eosinophil activation in asthmatics

Although cortico steroids are effective anti-inflammatory agents in ameliorating asthma symptoms and bronchial hperreactivity, their mechanism of action is unknown. Interleukin (IL)-5 is known to play a key role in regulating eosinophil proliferation and activation. Therefore, we examined the changes of IL-5 mRNA expressions in PBMC semi-quantitatively with RT-PCR as well as serum ECP levels and MCH-PC20 values in asthmatics before and after being treated with corticosteroids. The results revealed that there were significant decrease in the level of IL-5 mRNA and serum ECP concentration after therapy (P < 0.05) and there was remarkable improvement in the values of MCH-PC20 and FEV1% (P < 0.05). It was also found that the changes of serum ECP levels or MCH-PC20 values were accompanied by a reduction in IL-5 mRNA expression (r = 0.5426 or 0.4857, P < 0.05). These results suggested that the therapeutic effects of corticosteroids in asthma may result from modulation of IL-5 gene expression with consequent inhibition of eosinophil activation.     

威海市污水处理深海排放工程的设计

威海市污水处理深海排放工程是为改善其水域环境而建设的一英包括市区排水系统，污水预处理厂，输水管道和海洋放流管系统在内的完整而典型的工程，因此其工程设计扣的经验将会对同类项目的设计与工程建设有所借鉴。     

A new monitoring system for piping systems in fossil fired power plants

A CEC-funded project has been performed to tackle the problem of producing an advanced Life Monitoring System (LMS) which would calculate the creep and fatigue damage experienced by high temperature pipework components. Four areas were identified where existing Life Monitoring System technology could be improved:

1. 1. the inclusion of creep relaxation

2. 2. the inclusion of external loads on components

3. 3. a more accurate method of calculating thermal stresses due to temperature transients

4. 4. the inclusion of high cycle fatigue terms.

The creep relaxation problem was solved using stress reduction factors in an analytical in-elastic stress calculation. The stress reduction factors were produced for a number of common geometries and materials by means of non-linear finite element analysis. External loads were catered for by producing influence coefficients from in-elastic analysis of the particular piping system and using them to calculate bending moments at critical positions on the pipework from load and displacement measurements made at the convenient points at the pipework. The thermal stress problem was solved by producing a completely new solution based on Green's Function and Fast Fourier transforms. This allowed the thermal stress in a complex component to be calculated from simple non-intrusive thermocouple measurements made on the outside of the component. The high-cycle fatigue problem was dealt with precalculating the fatigue damage associated with standard transients and adding this damage to cumulative total when a transient occurred.

The site testing provided good practical experience and showed up problems which would not otherwise have been detected.     

Study of photosensitive mixtures of TMAE and helium, hydrocarbon or CF4-based carrier gases

Among the photocathodes used for particle identification based on the Cherenkov Ring Imaging technique, the TMAE molecule is still the best in terms of quantum efficiency. Despite the fact that TMAE gaseous photocathodes have already been used in a number of large experiments, one still seeks answers to many detailed questions. We present a systematic study of gaseous photocathodes based on TMAE mixed with helium, hydrocarbon and CF₄-based gases at normal pressure. The study includes a measurement of the electron drift velocity, gas quenching properties, single electron pulse height spectra and anode wire aging. The paper makes recommendations for carrier gas mixtures to obtain the best quenching, and suggests how to manage TMAE wire aging. This study was motivated by a specific particle identification detector proposal, the Fast Drift CRID proposed for the B-factory at SLAC.     

A Special Structure in Al-Mg-Li Alloy (01420) Weld Metal

A large quantity of laminated fine grain zones were observed in the Al-Mg-Li alloy weld metal by manual TIG, which was not found in ordinary Al alloy welds. The fine grain zone is formed because of the Al3(Zr,Ti) particles in the filler metal and the manual filling of filler metal in welding process     

CA／PAN中空纤维血浆分离膜的结构与性能

本研究以CA及PAN的共混溶液,通过干-湿法纺丝制取中空纤维,利用共混高聚物各组分在凝固剂中相分离速度的差异,形成具有稳定结构的中空纤维孔膜,该膜用于分离血液中的血浆成分具有良好效果。讨论了成型条件及添加剂等对膜结构、性能的影响,用SEM及图相分析仪、MAP压汞仪及DSC等分析手段,对膜的微孔结构、形态、孔尺寸及中空纤维膜的血浆通量和水通量等进行了系统的考查。     

混合Hermite-Lagrange插值之同时逼近

对于(-1,1)中的结点组{X_k}_(k=1)~n,记l_k(x)为相应的Lagrange插值基本多项式,又记A_n=‖∑(2-x~2-x_k~2)(1-x_k~2)~-1丨l_k(x)‖。对于f∈C_([-1,1)~q与r=[q+2/2],本文证明满足条件H_n(f,x_k)=f(x_k)(k=1,2,…,n),H_n~(s)(f,±1)=f~(s)(±1)(s=0,1,…,n-1)的n+2r-1次代数多项式H_n(f,x)有逼近性质H_n~(s)(f,x)-f~(s)(x)=(?)其中δ_n(x)=n~(-1)(1-x~2)~(1/2),△_n(x)=δ_n(x)+n~(-2).作为证明的重要工具,本文还对n次代数多项式P_n(x),建立了另一形式的Bernstein不等武:若 P_n(x)=O(1)δ_n~q(x)ω(δ_n(x)),则p_n~(S)(X)=O(1)δ_n~(q-2S)(X)ω(δ_n(X))△_n~s(X)。     

The zinc-rich corner of the Zn-Fe-Ni-Si quaternary system at 450 °C

Following up on recent studies of the Zn-rich corners of the Zn-Fe-Ni and Zn-Fe-Si ternary systems, a 450 °C isothermal section of the Zn-Fe-Ni-Si quaternary phase diagram with the Zn composition being fixed at 93 at.% was determined experimentally using optical microscopy, scanning electron microscopy (SEM) coupled with energy dispersive x-ray spectroscopy (EDS), and x-ray diffractometry (XRD). FeSi was found to be in equilibrium with almost all phases in the section, including the T, ζ, Ni-δ, NiSi₂, and FeSi₂ phases, as well as the liquid phase (L). Silicon solubilities in the T, ζ, and Ni-δ phases were rather limited. However, the solubilities of Fe and Zn in the NiSi₂ phase, at 4.5 at.% and 7.2 at.%, respectively, were appreciable. The existence of the (L+NiSi₂+Ni-δ) three-phase equilibrium state apparently prevents other Ni-Si compounds from entering equilibrium with the liquid at 450 °C. No true quaternary compound was found in the study.     

利用反射纵波评价裂缝倾角的模拟实验研究

声波全波列测井中的反射纵波可以用来评价高角度裂缝和对井周附近地质结构进行成像。目前的研究主要侧重于直接从波形资料处理出发计算裂缝的位置和倾角 ,其可靠性和准确性无从评价和校验。文中采用模拟实验的方法记录了倾角为 6 0°～80°范围内的 8种倾角裂缝的反射脉冲纵波波形 ,自行推导了反演裂缝倾角的公式 ,结合波场分离技术对实验测量波形数据进行了处理 ,计算出的裂缝倾角与实际值具有良好的一致性。本文结果表明 ,利用至少 2个深度点的纵波反射波波形资料就可以准确地反演裂缝的倾角