全文获取类型
收费全文 | 1299篇 |
免费 | 133篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 20篇 |
综合类 | 3篇 |
化学工业 | 388篇 |
金属工艺 | 27篇 |
机械仪表 | 14篇 |
建筑科学 | 70篇 |
矿业工程 | 5篇 |
能源动力 | 38篇 |
轻工业 | 82篇 |
水利工程 | 14篇 |
石油天然气 | 2篇 |
无线电 | 118篇 |
一般工业技术 | 241篇 |
冶金工业 | 147篇 |
原子能技术 | 8篇 |
自动化技术 | 257篇 |
出版年
2024年 | 3篇 |
2023年 | 32篇 |
2022年 | 61篇 |
2021年 | 80篇 |
2020年 | 52篇 |
2019年 | 70篇 |
2018年 | 71篇 |
2017年 | 67篇 |
2016年 | 73篇 |
2015年 | 59篇 |
2014年 | 70篇 |
2013年 | 73篇 |
2012年 | 67篇 |
2011年 | 102篇 |
2010年 | 45篇 |
2009年 | 46篇 |
2008年 | 49篇 |
2007年 | 54篇 |
2006年 | 41篇 |
2005年 | 19篇 |
2004年 | 21篇 |
2003年 | 15篇 |
2002年 | 13篇 |
2001年 | 14篇 |
2000年 | 15篇 |
1999年 | 13篇 |
1998年 | 47篇 |
1997年 | 26篇 |
1996年 | 20篇 |
1995年 | 8篇 |
1994年 | 4篇 |
1993年 | 6篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1985年 | 7篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1977年 | 8篇 |
1976年 | 6篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1973年 | 6篇 |
1972年 | 3篇 |
1969年 | 3篇 |
1904年 | 2篇 |
排序方式: 共有1434条查询结果,搜索用时 11 毫秒
71.
Age-related macular degeneration (AMD) is the major reason for blindness in the industrialized world with limited treatment options. Important pathogenic pathways in AMD include oxidative stress and vascular endothelial growth factor (VEGF) secretion. Due to their bioactivities, fucoidans have recently been suggested as potential therapeutics. This review gives an overview of the recent developments in this field. Recent studies have characterized several fucoidans from different species, with different molecular characteristics and different extraction methods, in regard to their ability to reduce oxidative stress and inhibit VEGF in AMD-relevant in vitro systems. As shown in these studies, fucoidans exhibit a species dependency in their bioactivity. Additionally, molecular properties such as molecular weight and fucose content are important issues. Fucoidans from Saccharina latissima and Laminaria hyperborea were identified as the most promising candidates for further development. Further research is warranted to establish fucoidans as potential therapeutics for AMD. 相似文献
72.
The generation of dispersions with defined droplet size distributions is important for liquid-liquid extraction. In this respect, the capability of a centrifugal pump to generate dispersions was investigated for different operating points. For the analysis of the mixing process, a centrifugal pump was designed translucent. High-speed images reveal the mechanism of particle breakup. Optical measurement technology and image processing with neural networks were used to determine droplet size distributions. The influence of flow rate, rotational frequency and holdup are discussed for a paraffin oil-water system. 相似文献
73.
Potential mGAT4 inhibitors derived from the lead substance (S)-SNAP-5114 have been synthesized and characterized for their inhibitory potency. Variations from the parent compound included the substitution of one of its aromatic 4-methoxy and 4-methoxyphenyl groups, respectively, with a more polar moiety, including a carboxylic acid, alcohol, nitrile, carboxamide, sulfonamide, aldehyde or ketone function, or amino acid partial structures. Furthermore, it was investigated how the substitution of more than one of the aromatic 4-methoxy groups affects the potency and selectivity of the resulting compounds. Among the synthesized test substances (S)-1-{2-[(4-formylphenyl)bis(4-methoxyphenyl)-methoxy]ethyl}piperidine-3-carboxylic acid, that features a carbaldehyde function in place of one of the aromatic 4-methoxy moieties of (S)-SNAP-5114, was found to have a pIC50 value of 5.89±0.07, hence constituting a slightly more potent mGAT4 inhibitor than the parent substance while showing comparable subtype selectivity. 相似文献
74.
MS Binding Assays are a label‐free alternative to radioligand binding assays. They provide basically the same capabilities as the latter, but an unlabeled reporter ligand is used instead of a radioligand. The study presented herein describes the development of MS Binding Assays that address D1 and D5 dopamine receptors. A highly sensitive, rapid and robust LC–ESI‐MS/MS quantification method for the selective D1 dopamine receptor antagonist SCH23390 ((5R)‐8‐chloro‐3‐methyl‐5‐phenyl‐1,2,4,5‐tetrahydro‐3‐benzazepin‐7‐ol) was established and validated, using its 8‐bromo analogue SKF83566 as an internal standard. This quantification method proved to be suitable for the characterization of SCH23390 binding to human D1 and D5 receptors. Following the concept of MS Binding Assays, saturation experiments for D1 and D5 receptors were performed, as well as competition experiments for D1 receptors. The results obtained are in good agreement with results from radioligand binding assays and therefore indicate that the established MS Binding Assays addressing D1 and D5 receptors are well‐suited substitutes for radioligand binding assays, the technique that has so far dominated affinity determinations toward these targets. 相似文献
75.
Structure and conductivity of yttria and scandia‐doped zirconia crystals grown by skull melting 下载免费PDF全文
Mihail A. Borik Sergey I. Bredikhin Vladimir T. Bublik Aleksej V. Kulebyakin Irina E. Kuritsyna Elena E. Lomonova Philipp O. Milovich Valentina A. Myzina Vyacheslav V. Osiko Polina A. Ryabochkina Nataliya Y. Tabachkova 《Journal of the American Ceramic Society》2017,100(12):5536-5547
In this paper a detailed study of the (ZrO2)1‐x(Y2O3)x (x=0.025–0.15), (ZrO2)1‐x(Sc2O3)x (x = 0.06 – 0.11) and (ZrO2)1‐x‐y(Sc2O3)x(Y2O3)y (x=0.07 – 0.11; y=0.01 – 0.04) solid solution crystals grown by skull melting technique is presented. The structure, phase composition, and ion conductivity of the obtained crystals were investigated by X‐ray diffraction, transmission electron microscopy, Raman scattering spectroscopy, and impedance spectroscopy. Maximum conductivity as (ZrO2)1‐x(Y2O3)x and (ZrO2)1‐x(Sc2O3)x solid solution crystals is observed for the compositions containing 10 mol% stabilizing oxide, and the conductivity of 10ScSZ is ~3 times higher than for 10YSZ. Experiments on crystal growth (ZrO2)1‐x‐y(Sc2O3)x(Y2O3)y solid solutions showed that uniform, transparent crystals 7Sc3YSZ, 7Sc4YSZ, 8Sc2YSZ, 8Sc3YSZ, 9Sc2YSZ, 9Sc3YSZ, 10Sc1YSZ, and 10Sc2YSZ are single phase crystal containing t″ phase. It is established that a necessary condition of melt growth of (ZrO2)1‐x‐y(Sc2O3)x(Y2O3)y single‐phase crystals is the total concentration of the stabilizing oxides from 10 to 12 mol%. The addition of Y2O3 affects the (ZrO2)1‐x‐y(Sc2O3)x(Y2O3)y solid solution conductivity different ways and depends on the Sc2O3 content in the starting composition. The effects of structure, phase composition, concentration, and type of stabilizing oxides on the electrical characteristics of obtained crystals are discussed. 相似文献
76.
The synthesis of the 4‐(dialkylamino)pyridine derivative 3‐(4‐(pyridin‐4‐yl)piperazin‐1‐yl)propyl methacrylate and its copolymerization with n‐butyl methacrylate are presented. The catalytic activity was evaluated in the acylation of tert‐butanol with acetic anhydride yielding tert‐butyl acetate. It is observed that the activity of polymer‐attached 4‐(dimethylamino)pyridine analogues correlates remarkably well with the chemical shift of the β‐pyridyl protons. Differences in catalytic efficiency result from distinct electronic densities of the pyridine ring, while embedding the catalytically active moiety into a polymeric structure has nearly no deleterious effect on the performance. © 2015 Society of Chemical Industry 相似文献
77.
Electrochemical characterization of laser‐carbonized polyacrylonitrile nanofiber nonwovens 下载免费PDF全文
Dennis Go Martin Opitz Philipp Lott Khosrow Rahimi Jochen Stollenwerk Helga Thomas Martin Möller Bernhard Roling Alexander J. C. Kuehne 《应用聚合物科学杂志》2018,135(25)
Porous carbon materials represent prospective materials for absorbers, filters, and electronic applications. Carbon fibers with high surface areas can be produced from polyacrylonitrile and spun as thin fibers from solution. The resulting polymer fibers are first stabilized to obtain conjugated ribbons and then carbonized to graphitic structures in a second high‐temperature step in an inert atmosphere. In this study, we investigated a previously described fast laser‐heating process that delivered fibers with a higher crystallinity and surface area compared to the thermally carbonized fibers. In a subsequent KOH‐activation step, the crystalline domains were exfoliated, and the surface of the fibers became macroporous. This led to a reduced specific surface area but a higher capacitance compared to thermally carbonized nanofibers. We report the electrochemical properties of the electrochemical cells and discuss their potential applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 46398. 相似文献
78.
Jadran Vrabec Martin Bernreuther Hans‐Joachim Bungartz Wei‐Lin Chen Wilfried Cordes Robin Fingerhut Colin W. Glass Jürgen Gmehling René Hamburger Manfred Heilig Matthias Heinen Martin T. Horsch Chieh‐Ming Hsieh Marco Hülsmann Philip Jäger Peter Klein Sandra Knauer Thorsten Köddermann Andreas Köster Kai Langenbach Shiang‐Tai Lin Philipp Neumann Jürgen Rarey Dirk Reith Gábor Rutkai Michael Schappals Martin Schenk Andre Schedemann Mandes Schönherr Steffen Seckler Simon Stephan Katrin Stöbener Nikola Tchipev Amer Wafai Stephan Werth Hans Hasse 《化学,工程师,技术》2018,90(3):295-306
This article outlines advances in molecular modeling and simulation using massively parallel high‐performance computers (HPC). In the SkaSim project, partners from the HPC community collaborated with users from science and industry. The aim was to optimize the prediction of thermodynamic property data in terms of efficiency, quality and reliability using HPC methods. In this context, various topics were dealt with: atomistic simulation of homogeneous gas bubble formation, surface tension of classical fluids and ionic liquids, multicriteria optimization of molecular models, the development of the molecular simulation codes ls1 mardyn and ms2, atomistic simulation of gas separation processes, molecular membrane structure generators, transport resistors and the evaluation of predictive property data models based on specific mixture types. 相似文献
79.
80.
Analysis of the Insect OS-D-Like Gene Family 总被引:9,自引:0,他引:9
Wanner KW Willis LG Theilmann DA Isman MB Feng Q Plettner E 《Journal of chemical ecology》2004,30(5):889-911
Insect OS-D-like proteins, also known as chemosensory (CSP) or sensory appendage proteins (SAP), are broadly expressed in various insect tissues, where they are thought to bind short to medium chain length fatty acids and their derivatives. Although their specific function remains uncertain, OS-D-like members have been isolated from sensory organs (including the sensillum lymph in some cases), and a role in olfaction similar to that of the insect odorant binding proteins (OBP) has been suggested for some. We have identified 15 new OS-D-like sequences: four from cDNA clones described herein and 11 from sequence databases. The os-d-like genes from the Anopheles gambiae, Apis mellifera, Drosophila melanogaster, and Drosophila pseudoobscura genomes typically have single, small introns with a conserved splice site. Together with all family members entered on GenBank, a total of 70 OS-D-like proteins, representing the insect orders Diptera, Dictyoptera, Hymenoptera, Lepidoptera, Orthoptera, and Phasmatodea, were analyzed. A neighbor joining distance phenogram identified several protein similarity classes that were characterized by highly conserved sequence motifs, including (A) N-terminal YTTKYDN(V/I)(N/D)(L/V)DEIL, (B) central DGKELKXX(I/L)PDAL, and (C) C-terminal KYDP. In contrast, three similarity classes were characterized by their diversion from these conserved motifs. The functional importance of conserved amino acid residues is discussed in relation to the crystal and NMR structures of MbraCSPA6. 相似文献