Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment

The immediate and delayed metabolic changes in rats treated with valproate (VPA), a drug used for the treatment of epilepsy, were profiled. An established approach using dried blood spots (DBS) as sample matrices for gas chromatography/mass spectrometry-based metabolomics profiling was modified using double solvents in the extraction of analytes. With the modified method, some of the previously undetectable metabolites were recovered and subtle differences in the metabolic changes upon exposure to a single dose of VPA between males and female rats were identified. In male rats, changes in 2-hydroxybutyric acid, pipecolic acid, tetratriacontane and stearic acid were found between the control and treatment groups at various time points from 2.5 h up to 24 h. In contrast, such differences were not observed in female rats, which could be caused by the vast inter-individual variations in metabolite levels within the female group. Based on the measured DBS drug concentrations, clearance and apparent volume of distribution of VPA were estimated and the values were found to be comparable to those estimated previously from full blood drug concentrations. The current study indicated that DBS is a powerful tool to monitor drug levels and metabolic changes in response to drug treatment.     

家庭安防系统中手机彩信报警的实现

利用LabVIEW软件开发了集现场数据采集、传送及远程监视于一体的彩信实时报警系统。当监控现场有非法侵入时,控制主机收到被触发的探测器报警信号后立即启动相应的模块采集现场的声音与图像,经信号处理后以最直观的彩信形式,通过GPRS网络发送到用户设定的手机。系统运行结果表明,数据发送稳定、实时性好,声音和图像清晰,可以作为传统报警方式的补充,也可应用于其他方面的远程监控。     

一种新型无杆泵投捞式电缆研制与应用

无杆举升技术具有系统效率高、节能、安全环保等优势,且解决了管杆偏磨等问题,是新型举升技术的发展方向.无杆泵动力电缆采用绑缚在油管外壁的方式下入,存在提下管柱时电缆故障率高、操作复杂等缺点,制约了无杆泵的应用.研发了新型投捞式电缆,下入方式改为从油管内部投入,避免了油套环空间隙狭小而导致的电缆磕碰损坏,提高了作业效率.对...     

天然裂缝性油藏渗吸规律

为了研究渗吸作用对天然裂缝性油藏的影响,改善该类油藏的开发效果,以数值模拟为手段,通过建立概念地质模型,以静态和动态2种方式研究了毛细管压力、孔隙均匀程度、相渗曲线、基质和裂缝渗透率、原油黏度和基质含油饱和度对基质渗吸速度的影响,并在静态下对相关参数进行了公式拟合.静态下,渗吸速度与毛细管压力、基质渗透率、残余油饱和度、束缚水饱和度下的油相相对渗透率呈直线关系,与束缚水饱和度呈指数关系,与原油黏度呈幂指数关系;动态下,对于不同润湿性的油藏提出了不同的开发方式.     

低渗透储层应力敏感性定量解释研究

对致密及发育微裂缝、裂缝的低渗透岩心应力敏感性进行了实验;采用不等径迂曲毛管束模型,通过弹性力学原理对粗、细毛细管变形量的计算,研究了单毛细管和多孔介质应力敏感性定量表征关系,并通过有效毛细管半径分数探讨了低渗透储层应力敏感性的作用机制。研究表明,低渗透储层的应力敏感性主要表现为渗透率的应力敏感性,低、中高渗透率储层在应力敏感性上的差异与微观孔隙结构、固液界面作用力和启动压力梯度效应等密切相关,且这种差异性集中体现为有效毛细管半径分数的不同。考虑有效毛细管半径分数的多孔介质应力敏感性量化模型可以从应力敏感性微观作用机制角度解释低渗透储层与中高渗透率储层在应力敏感性上的差异。     

Wear Behavior of the Lead-Free Tin Bronze Matrix Composite Reinforced by Carbon Nanotubes

Copper-coated carbon nanotubes were prepared by the electroless plating route. The structure and component of copper/carbon tubes were characterized using a transmission electron microscope and energy dispersive spectrometer. The results show that the surface of the carbon tubes was covered by the copper particles. Copper/carbon tubes were used as the substitute of part of tin and all of lead in the tin bronze matrix, and the tribological properties of carbon nanotube-reinforced Cu-4 wt pct Sn-6 wt pct Zn composites were studied. The effects of the carbon nanotube volume fraction and sliding distance in unlubricated ball-on-disc wear test were investigated. The 3 vol pct carbon nanotube-reinforced Cu-4 wt pct Sn-6 wt pct Zn composite shows the Vickers hardness of 126.9, which is approximately 1.6 times higher than that of Cu-6 wt pct Sn-6 wt pct Zn-3 wt pct Pb tin bronze. The wear rate and average friction coefficients of 3 vol pct carbon nanotube-reinforced Cu-4 wt pct Sn-6 wt pct Zn composite were lower than those of the Cu-6 wt pct Sn-6 wt pct Zn-3 wt pct Pb tin bronze, respectively.     

城镇开发建设中的规划管理问题研究

近年来,我国各地都根据国家制定的城镇发展战略,对本地的城镇进行了规划部署与开发建设,既促进了城市经济的发展,又带动了农村经济的发展。但是在建设规划过程中,由于经验不足,暴露出来许多问题,对本地城镇建设造成一定的影响,因此对这些问题进行深入的剖析,并进行改进,对促进城镇建设有很大帮助。     

深基坑支护结构和施工新技术

简要介绍了我国基坑工程发展概况,重点介绍了复合土钉墙、双排桩、型钢水泥土搅拌墙等新型支护结构以及几种施工新设备、新工艺。分析了地下结构逆作法和利用"时空效应"开挖技术的工程应用。     

桶装饮用水藻类污染检测技术研究

在改良克氏 (Pringsheim’s)液无机盐组分中 ,添加适量的土壤提取液、微量元素、抗生素等 ,通过比较小球藻、栅藻等藻类的生长情况和实际样品的测试 ,研制出藻类 2 # 培养基。采用液体大样法或琼脂平板法 ,2 5～ 2 8℃光照静置培养 5～ 10d ,可对饮用矿泉水、纯净水生产中污染的藻类进行定性或定量检测