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101.
102.
Rongrong Luo Lei Chen Xingxing Song Xin Zhang Wenhao Xu Dongyang Han Jianyu Zuo Wen Hu Yan Shi Yajie Cao Runwen Ma Chengcheng Liu Changlin Xu Zixin Li Xun Li 《International journal of molecular sciences》2022,23(15)
Gonadotropin-inhibitory hormone (GnIH) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis and reproduction. However, whether GnIH is a molecular signal link of metabolism and the reproductive system, and thus, regulates reproductive activity as a function of the energy state, is still unknown. In the present study, we investigated the involvement of GnIH in glycolipid metabolism and reproduction in vivo, and in the coupling between these two processes in the testis level. Our results showed that chronic intraperitoneal injection of GnIH into male mice not only increased food intake and altered meal microstructure but also significantly elevated body mass due to the increased mass of liver and epididymal white adipose tissue (eWAT), despite the loss of testicular weight. Furthermore, chronic intraperitoneal administration of GnIH to male mice resulted in obesity-related glycolipid metabolic derangements, showing hyperlipidemia, hyperglycemia, glucose intolerance, and insulin resistance through changes in the expression of glucose and lipid metabolism-related genes in the pancreas and eWAT, respectively. Interestingly, the expression of GnIH and GPR147 was markedly increased in the testis of mice under conditions of energy imbalance, such as fasting, acute hypoglycemia, and hyperglycemia. In addition, chronic GnIH injection markedly inhibited glucose and lipid metabolism of mice testis while significantly decreasing testosterone synthesis and sperm quality, inducing hypogonadism. These observations indicated that orexigenic GnIH triggers hyperphagia-induced obesity-related metabolic derangements and hypogonadism in male mice, suggesting that GnIH is an emerging candidate for coupling metabolism and fertility by involvement in obesity and metabolic disorder-induced reproductive dysfunction of the testes. 相似文献
103.
采用三种不同沉积韵律平面模型试验研究水驱后聚合物与水气交替联驱提高原油采收率的驱替特征。结果表明,聚合物与水气交替联驱对正韵律油藏提高采收率效果很好;对反韵律油藏和复合韵律油藏也有不同程度提高采收率效果。通过分析两种不同韵律砂岩油藏水气交替提高采收率矿场试验成功实例,认为聚合物与水气交替联驱法可综合发挥两种方法的优势,在类似油藏中比单一方法有更好的提高采收率效果。 相似文献
104.
105.
曹双华 《建筑热能通风空调》2007,26(6):18-22
在许多领域的计算与应用中,常需借助室外干球温度的逐时资料。以可照时数为依据,可把室外干球温度划分为两大部分,分别为室外干球温度日段与夜段部分。本文通过改进递归神经网络,以气象站记录的室外干球温度日4值历史数据以及它的影响因素为基础,再结合室外干球温度日段部分的特性,建立了室外干球温度日段逐时预测模型。预测结果显示所建立的模型是合理可靠的。 相似文献
106.
对门式和桥式起重机采用凸轮开关切换线绕转子中串接的电阻来控制速度时,易发生桥架"抖动"问题展开研究,认为为了改善电动机械特性和控制性能,较好的办法就是选用变频器进行控制。介绍了变频器的工作原理的控制方法。 相似文献
107.
Wei-Feng Liu Bi-Jun Xie Ming-Yue Sun Bin Xu Yan-Fei Cao Dian-Zhong Li 《金属学报(英文版)》2022,35(11):1837-1848
The interfacial oxidation behavior of Cr4 Mo4 V high-speed steel(HSS) joints undergoing hot-compression bonding was investigated by using optical microscopy(OM),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).In the heating and holding processes,dispersed rod-like and granular δ-Al2 O3 oxides were formed at the interface and in the matrix near the interface due to the selective oxidation and internal oxidation of Al,while irregular Si-Al-O compou... 相似文献
108.
109.
Jianfeng Wanyan Kun Cao Zhiping Chen Yun Li Chenxi Liu Runqing Wu Xiao-Dong Zhang Rong Chen 《工程(英文)》2021,7(10):1459-1468
The reliable operation of flexible display devices poses a significant engineering challenge regarding the metrology of high barriers against water vapor. No reliable results have been reported in the range of 10–6 g∙(m2∙d)−1, and there is no standard ultra-barrier for calibration. To detect trace amount of water vapor permeation through an ultra-barrier with extremely high sensitivity and a greatly reduced test period, a predictive instrument was developed by integrating permeation models into high-sensitivity mass spectrometry measurement based on dynamic accumulation, detection, and evacuation of the permeant. Detection reliability was ensured by means of calibration using a standard polymer sample. After calibration, the lower detection limit for water vapor permeation is in the range of 10–7 g∙(m2∙d)−1, which satisfies the ultra-barrier requirement. Predictive permeation models were developed and evaluated using experimental data so that the steady-state permeation rate can be forecasted from non-steady-state results, thus enabling effective measurement of ultra-barrier permeation within a significantly shorter test period. 相似文献
110.
Two-dimensional (2D) perovskites are known as one of the most promising luminescent materials due to their structural diversity and outstanding optoelectronic p... 相似文献