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Ping Huang Guangwei Chen Weifeng Jin Kunjun Mao Haitong Wan Yu He 《International journal of molecular sciences》2022,23(13)
Differential evolution of apoptosis, programmed necrosis, and autophagy, parthanatos is a form of cell death mediated by poly(ADP-ribose) polymerase 1 (PARP1), which is caused by DNA damage. PARP1 hyper-activation stimulates apoptosis-inducing factor (AIF) nucleus translocation, and accelerates nicotinamide adenine dinucleotide (NAD+) and adenosine triphosphate (ATP) depletion, leading to DNA fragmentation. The mechanisms of parthanatos mainly include DNA damage, PARP1 hyper-activation, PAR accumulation, NAD+ and ATP depletion, and AIF nucleus translocation. Now, it is reported that parthanatos widely exists in different diseases (tumors, retinal diseases, neurological diseases, diabetes, renal diseases, cardiovascular diseases, ischemia-reperfusion injury...). Excessive or defective parthanatos contributes to pathological cell damage; therefore, parthanatos is critical in the therapy and prevention of many diseases. In this work, the hallmarks and molecular mechanisms of parthanatos and its related disorders are summarized. The questions raised by the recent findings are also presented. Further understanding of parthanatos will provide a new treatment option for associated conditions. 相似文献
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Bao Wan Xiao-Qiang Li Cun-Liang Pan Dong-Yu Li Sheng-Guan Qu Chao Yang 《稀有金属(英文版)》2021,(8):2134-2142
For the purpose of elevated temperature service and weight reduction in aerospace vehicle applications,a novel Ti-Zr-Fe-Cu-Ni-Co-Mo filler metal was employed to... 相似文献
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1 INTRODUCTIONAntimonymercaptides[1~ 4 ] usedasheatstabiliz erisattractivenotonlyforitsrelativelylowcost ,butalsoforitssimilarstabilizingeffectcomparedwiththatofthemostexcellentone organotin .Bymakingfulluseoftheplentifulantimonyresource ,developingantimonym… 相似文献
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Xiao Zhang Daoming Liu Dong Gao Weining Zhao Huaying Du Zeyu Qiu Jie Huang Peizheng Wen Yongsheng Wang Qi Li Wenhui Wang Haosen Xu Jun He Yuqiang Liu Jianmin Wan 《International journal of molecular sciences》2022,23(11)
Plants have evolved a sophisticated defense system that employs various hormone pathways to defend against attacks by insect pests. Cytokinin (CK) plays an important role in plant growth and stress tolerance, but the role of CKs in plant–insect interaction remains largely unclear. Here, we report that CKs act as a positive regulator in rice resistance against brown planthopper (BPH), a devastating insect pest of rice. We found that BPH feeding promotes CK biosynthesis and signaling in rice. Exogenous application of CKs significantly increased the rice resistance to BPH. Increasing endogenous CKs by knocking out cytokinin oxidase/dehydrogenase (OsCKXs) led to enhanced resistance to BPH. Moreover, the levels of the plant hormone jasmonic acid (JA) and the expression of JA-responsive genes were elevated by CK treatment and in OsCKXs knockout plants. Furthermore, JA-deficient mutant og1 was more susceptible to BPH, and CK-induced BPH resistance was suppressed in og1. These results indicate that CK-mediated BPH resistance is JA-dependent. Our findings provide the direct evidence for the novel role of CK in promoting insect resistance, and demonstrate that CK-induced insect resistance is JA-dependent. These results provide important guidance for effective pest management strategies in the future. 相似文献
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本文以连通片检测器无性模板的设计为例,给出了细胞神经网络中无性模板的设计方法及连通片检测器无性模板中各元素的数值范围。 相似文献
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With the development of MEMS and the electronic devices's miniaturization and integration, a new kind of power sources that can satisfy the need for high energy density is required. Microbatteries are being researched abroad for their advantages of extreme thinness and long-term power supply. The development of MEMS microbatteries are reviewed and suggestedmagnetron sputtering in fabricating a high-performance microbattery. The technics as annealing are analyzed. The microbattery with a LiNi1-x Cox O2 cathode exhibited stable cycle ability and a high specific discharge capacity, which was attributed to the alloying effect of the LiNiO2and LiCoO2. 相似文献
30.
梅山汽车运输分公司运翔码头原设计为1500吨级码头,为适应市场发展需要,要停靠5000吨级船舶。从现运翔码头前沿航行水深、码头设施、防护设施等实际出发对安全停靠5000吨级船舶进行可行性论证。 相似文献