Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism

As the most recent melanocortin receptor (MCR) identified, melanocortin-5 receptor (MC5R) has unique tissue expression patterns, pharmacological properties, and physiological functions. Different from the other four MCR subtypes, MC5R is widely distributed in both the central nervous system and peripheral tissues and is associated with multiple functions. MC5R in sebaceous and preputial glands regulates lipid production and sexual behavior, respectively. MC5R expressed in immune cells is involved in immunomodulation. Among the five MCRs, MC5R is the predominant subtype expressed in skeletal muscle and white adipose tissue, tissues critical for energy metabolism. Activated MC5R triggers lipid mobilization in adipocytes and glucose uptake in skeletal muscle. Therefore, MC5R is a potential target for treating patients with obesity and diabetes mellitus. Melanocortin-2 receptor accessory proteins can modulate the cell surface expression, dimerization, and pharmacology of MC5R. This minireview summarizes the molecular and pharmacological properties of MC5R and highlights the progress made on MC5R in energy metabolism. We poInt. out knowledge gaps that need to be explored in the future.     

Phloroglucinol Derivative Carbomer Hydrogel Accelerates MRSA-Infected Wounds’ Healing

Globally, wound infection is considered to be one of the major healthcare problems, with bacterial infections being the most critical threat, leading to poor and delayed wound healing, and even death. As a superbug, methicillin-resistant Staphylococcus aureus (MRSA) causes a profound hazard to public health safety, prompting us to search for alternative treatment approaches. Herein, the MTT test and Hoechst/propidium iodide (PI) staining demonstrated that PD was slightly less toxic to human fibroblasts including Human keratinocytes (HaCaT) cell line than Silver sulfadiazine (SSD), and Vancomycin (Van). In the MRSA-infected wound model, PD hydrogel (1%, 2.5%) was applied with for 14 days. The wound healing of PD hydrogel groups was superior to the SSD, Van, and control groups. Remarkably, the experimental results showed that PD reduced the number of skin bacteria, reduced inflammation, and upregulated the expression of PCNA (keratinocyte proliferation marker) and CD31 (angiogenesis manufacturer) at the wound site by histology (including hematoxylin–eosin (HE) staining, Masson staining) and immunohistochemistry. Additionally, no toxicity, hemocompatibility or histopathological changes to organs were observed. Altogether, these results suggested the potential of PD hydrogel as a safe, effective, and low toxicity hydrogel for the future clinical treatment of MRSA-infected wounds.     

基于动态网格的移动对象索引

在移动对象数据库中,移动对象的数量可能会经常变化,这就给索引技术提出了新的挑战。移动对象索引技术的效率是移动对象数据库的一个重要研究课题。为了防止数据库由于移动对象数量的变化而导致性能锐减,本文在网格文件索引的基础上提出了一种动态网格索引技术。通过实验比较显示,它相对于静态索引具有更好的适应性。     

面向雨数的循环优化序列定制方法

讨论了一种可针对程序中的不同函数(routine)采用不同的循环优化序列的方法,该方法基于polyhedron模型,使用简化cache失效率方程分别对每一个函数作优化序列评估,以迭代编译方式为每个函数寻找一个独特的循环优化序列.该方法降低了变换实施的复杂度,降低了对编译器具体实现的依赖;考虑程序中不同函数的差异以获得更好的优化效果.对SPEC2006的实验数据表明,经过定制优化之后,较之Open64-03,加速比为1.05～1.13.     

基于多信号模型的故障诊断算法研究

多信号模型是一种简单而有效的系统建模表示方法,在测试性分析与故障诊断领域得到了广泛的应用;本文结合示例给出了多信号模型的建模和分析过程,并由多信号模型得到了故障-测试相关矩阵;在信息熵理论的基础上,通过定义新的目标函数,本文对最优测试序列的生成进行了具体算法分析,并由此得出了最优诊断树,与TEAMS工具箱的仿真结果一致;和其他方法相比,该方法不仅结果更加优化,而且效率更高,易于计算机编程实现,对测试性分析工具的研发具有一定的参考价值。     

一种基于规则分解映射的防火墙规则匹配算法

并行树搜索(PTS)算法是报文分类领域中较为优秀的算法之一,但它需要构建大量的external nodes,且只支持以前缀形式表示的规则,因此其匹配效率及适用范围都受到了很大的影响.针对这一问题,提出一种基于规则分解映射的规则匹配算法RMBRDM.RMBRDM算法首先按照启发式方法选取标准维;然后根据规则分解映射和标准维对相关规则进行分解;最后建立一棵二叉决策树.理论分析和仿真实验均表明,RMBRDM算法不仅支持以范围形式表示的规则,且时空性能优于PTS算法.     

通用测试系统模型化技术研究

针对通用自动测试系统(ATS)通用性的需求,对自动测试系统进行了模型化处理,并针对目前测试系统模型化设计的不足,提出了基于COM技术的可互换测试系统模型。该模型利用数据库将测试设备的功能进行组件化处理,测试程序集(TPS)可通过特定接口直接使用特定功能,实现了测试程序与硬件的分离,提高了TPS的可移植性。同时利用数据库软件对系统模型进行管理,减小可硬件更换对系统软件的影响。实践证明,系统模型化处理后所需适配器种类减少,测试功能增强。     

Optimizing wheel profiles and suspensions for railway vehicles operating on specific lines to reduce wheel wear: a case study

Multibody System Dynamics - The selection of a wheel profile is a topic of great interest as it can affect running performances and wheel wear, which needs to be determined based on the actual...     

移动地理信息采集共享P2P Web Service平台

提出一种基于移动P2P Web Service的地理信息采集与共享平台MPPWS-GIGS（Mobile P2P Web Service Geography Information Gathering and Sharing）,目标是充分利用移动终端天然的分布式特点,支持地理信息的P2P采集和共享功能;为了克服现有移动网络的漫游性、带宽的局限性,通过中心控制服务器,基于目前移动网络支持的网络协议（UDP/TCP）,完成针对移动网络的终端管理、会话管理、服务管理等功能。