MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System

Nanoparticles of metal–organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. Herein, we develop porous capsules from aggregate of nanoparticles of the iron carboxylate MIL-100(Fe) through a low-temperature spray-drying route. This enables the concomitant one-pot encapsulation of high loading of an antitumor drug, methotrexate, within the pores of the MOF NPs, and the collagenase enzyme (COL), inside the inter-particular mesoporous cavities, upon the formation of the capsule, enhancing tumor treatment. This association provides better control of the release of the active moieties, MTX and collagenase, in simulated body fluid conditions in comparison with the bare MOF NPs. In addition, the loaded MIL-100 capsules present, against the A-375 cancer cell line, selective toxicity nine times higher than for the normal HaCaT cells, suggesting that MTX@COL@MIL-100 capsules may have potential application in the selective treatment of cancer cells. We highlight that an appropriate level of collagenase activity remained after encapsulation using the spray dryer equipment. Therefore, this work describes a novel application of MOF-based capsules as a dual drug delivery system for cancer treatment.     

ORIGIN软件在齿轮测量中的应用

以齿轮检测为例,说明了ORIGIN软件在检测中的使用方法,表明它在提高检测精度和检测效率方面的巨大作用。     

叶绿素荧光量子产量的MODIS遥感算法

从荧光量子产量的原理出发,利用 MODIS 卫星数据建立了一种估算量子产量的算法--φ算法.通过 2006 年 3 月 23 日渤海和北黄海的 MODIS 数据计算了荧光量子产量,并与叶绿素荧光效率(cFE)产品进行了比较.结果表明,φ算法是一种更精确的荧光量子产量的估算算法,它有效地避免了 CFE 存在的几个误差来源:包括未考虑浮游植物的"包裹效应"、使用 412nm 的离水辐亮度反演的浮游植物吸收系数以及积分深度过浅.CFE在大部分海域出现负值,还出现了某些高估点;在有效数据范围内,两者存在明显的线性相关关系.φ算法估算的量子产量最高值在0.05左右,这与其它海区测量的值域范围基本一致.除辽东湾东北部和部分近岸水域外,大部分离岸水域在0.001～0.02的范围内.通过对φ算法的误差来源分析,认为发展一种新的反演 678nm 比吸收系数和平均吸收系数的波段比值算法是可行的,也是改进φ算法精度的有效方法.     

Development of gated fiber detectors for laser-induced strong electromagnetic pulse environments

With the development of laser technologies,nuclear reactions can happen in high-temperature plasma environments induced by lasers and have attracted a lot of at...     

基于超图正则化的域适应偏最小二乘多工况软测量模型

针对流程工业中,因多工况导致数据分布变化引起传统软测量模型预测性能恶化问题,本文提出一种基于超图正则化的域适应多工况软测量回归模型框架.首先,采用非线性迭代偏最小二乘回归算法为基模型,在潜变量空间利用历史工况数据重构当前工况数据,以增强工况间的相关性,有效减小数据分布差异;同时,对重构系数施加低秩稀疏约束,保留了数据的局部和全局子空间结构;其次,通过超图拉普拉斯正则项对域适应潜变量求解过程进行约束,避免在寻找潜变量过程中破坏数据结构.最后,利用交替方向乘子法优化求解模型参数.在多个数据集上的实验表明,本文方法在多工况环境下可有效提高软测量模型的预测精度和泛化性能.     

面向锂电池少量循环的二维支持域直推式健康状态预测

锂离子电池的健康状态(SOH)是反映电池老化程度的关键指标,但由于电池老化的非线性和不确定性使得SOH难以精确估计,并且受到电池数据收集的高时间成本和容量再生现象的影响,传统的数据驱动方法在历史充放电循环数较少时效果较差.针对上述问题,本文创新性地提出了一种二维支持域直推式学习(2D-RoSTL)建模思路,建立了数据由粗到细的精准划分方法,用于少量充放电循环下的SOH预测.一方面,考虑同型号多块电池的批次特性,利用历史数据和批次数据构造二维支持域扩充模型信息来源,提供了粗范围的大量可供选择的样本;另一方面,首次尝试以直推式学习的方式解决SOH预测的任务,利用离线和在线样本特征空间的信息,对每个样本进行细致划分,提升少量充放电循环情况下模型的预测可靠性.基于NASA的公开数据集,所提出的二维支持域直推式建模方法在4个电池上的预测误差均小于1.56%,实现了对锂电池充放电历史初期及再生点的精确预测.     

改性海泡石除磷热力学研究

通过对改性海泡石的热力学性能研究,确定了改性海泡石对磷进行吸附的吸附容量、去除率和改性海泡石用量的关系。根据实验数据求解出吸附等温方程并绘制出等温吸附曲线。对等温吸附曲线进行拟合并比较相关系数的大小,得到改性海泡石的等温吸附方程。它符合修正后的Freundlich等温吸附方程:qe=10.4 4 Ci1.148 29.90。此方程较精确地描述了改性海泡石对P O34--的吸附量随浓度的变化,为改性海泡石的工业化除磷应用提供了理论依据。     

腈纶表面接枝蛋白质改性纤维的结构与性能

腈纶经过表面水解、酰氯化和接枝反应等过程在表面接枝上大豆蛋白质,制成了蛋白质接枝改性腈纶。对其进行物理力学性能分析、红外分析和电子显微镜形貌观察表明:改性腈纶在表面接枝蛋白质的效果明显,其表面完全覆盖上了完整致密的蛋白质表面膜层;X射线衍射分析表明,蛋白质接枝改性腈纶的超分子结构与普通腈纶相比并没有发生大的变化,基本保持了原有腈纶的高序态和低序态共存的结构特征。     

Research on the stability of nearly zero flattened dispersion of photonic crystal fibers

To analyze the stability of nearly zero flattened dispersion, the dispersion deviations for three kinds of PCFs are calculated when the hole diameters deviate from their designed values. Numerical results show that around the wavelength of 1.55 μm, the dispersion deviations of both the PCF with three-fold symmetry core and the PCF with hexagonal lattice are much less than that of the PCF with different hole diameters in different rings. Therefore, the stabilities of nearly zero flattened dispersion of the first two kinds of PCFs are much better than that of the last one. Considering the confinement loss, the PCF with three-fold symmetry core is preferable to practical use.