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101.
102.
Akane Yamamichi Fumiharu Ohka Hiromichi Suzuki Akira Kato Kazuya Motomura 《Science and Technology of Advanced Materials》2016,17(1):618-625
World Health Organization grade II and III gliomas most frequently occur in the central nervous system (CNS) in adults. Gliomas are not circumscribed; tumor edges are irregular and consist of tumor cells, normal brain tissue, and hyperplastic reactive glial cells. Therefore, the tumors are not fully resectable, resulting in recurrence, malignant progression, and eventual death. Approximately 69–80% of grade II and III gliomas harbor mutations in the isocitrate dehydrogenase 1 gene (IDH1), of which 83–90% are found to be the IDH1-R132H mutation. Detection of the IDH1-R132H mutation should help in the differential diagnosis of grade II and III gliomas from other types of CNS tumors and help determine the boundary between the tumor and normal brain tissue. In this study, we established a highly sensitive antibody-based device, referred to as the immuno-wall, to detect the IDH1-R132H mutation in gliomas. The immuno-wall causes an immunoreaction in microchannels fabricated using a photo-polymerizing polymer. This microdevice enables the analysis of the IDH1 status with a small sample within 15 min with substantially high sensitivity. Our results suggested that 10% content of the IDH1-R132H mutation in a sample of 0.33 μl volume, with 500 ng protein, or from 500 cells is theoretically sufficient for the analysis. The immuno-wall device will enable the rapid and highly sensitive detection of the IDH1-R132H mutation in routine clinical practice. 相似文献
103.
Kiyoharu Nakagawa Hirokazu Oda Akira Yamashita Masahiro Okamoto Yoichi Sato Hidenori Gamo Mikka Nishitani-Gamo Kazuyuki Ogawa Toshihiro Ando 《Journal of Materials Science》2009,44(1):221-226
We developed a novel spherical carbon material. The spherical carbon is composed of a high density of carbon nanotubes or
nanofilaments, and includes an oxidized diamond particle as a core. Syntheses of this carbon in high volume with high selectivity
may be possible. It is expected that this carbon will be useful as a catalyst material for fuel cells, electric double-layer
capacitors, etc. 相似文献
104.
In this study, we prepared monodisperse spherical particles of a desired diameter using [(Fe0.5Co0.5)0.75B0.2Si0.05]96Nb4 alloy; the particles were prepared by using an atomization process developed by us. The particles have perfect sphericity and narrow size distribution along with a homogeneous composition. The phase transitions of particles from the fully glassy phase to the crystalline phase via mixed phase structures occurred as the particle diameter was increased; the particles produced in the fully glassy phase in an argon atmosphere had a diameter of less than 300 μm. This allowed the estimation of the intrinsic critical cooling rate for the particles with a fully glassy phase, Rc:Rc varied in the range of 700-900 K/s and depended only on the initial temperature of the alloy melt. 相似文献
105.
Hiroki Ishikawa Ryoko Komaki Haruo Naitoh Akira Yamaba Hiroki Katoh 《Electrical Engineering in Japan》2010,173(1):51-59
This paper presents a current control design for switched reluctance motors (SRMs). The electric transfer characteristic of the motors is studied first. Their transfer function is shown to be expressible by a pure resistive component, which is not constant but varies depending on the motor current and speed. The current control design for SRMs follows the classical design technique used for DC machines, where the zeros of the PI controller cancel the poles of Ls+R. Because the transfer function of SRMs does not have any poles, an I controller is suitable for them. The integral gain should be adjusted in order to compensate the nonlinearity, that is, the variation in the equivalent resistor of the SRMs' transfer function. The values of the integral gain are tuned and tabulated for the motor speed and current. Simulation and experiment demonstrate that the current and speed of the SRMs present good responses without dependence on the motor speed and current. © 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 173(1): 51–59, 2010; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20987 相似文献
106.
Koh Matsumoto Kazutada Ikenaga Jun Yamamoto Kazuki Naito Yoshiki Yano Akinori Ubukata Hiroki Tokunaga Tadanobu Arimura Katsuaki Cho Toshiya Tabuchi Akira Yamaguchi Yasuhiro Harada Yuzaburo Ban Kousuke Uchiyama 《半导体学报》2011,32(1):21-23
Growth rate has a direct impact on the productivity of nitride LED production.Atmospheric pressure growth of GaN with a growth rate as high as 10μm/h and also Al0.1Ga0.9N growth of 1μm/h by using 4 inch by 11 production scale MOVPE are described.XRD of(002) and(102) direction was 200 arcsec and 250 arcsec, respectively.Impact of the growth rate on productivity is discussed. 相似文献
107.
108.
This study aimed to investigate the rheology of two-mineral mixture systems as a function of pH and solid concentration. Single minerals (nickel oxide, quartz and hematite) and two-mineral systems (nickel oxide–quartz and nickel oxide–hematite) were studied. Rheology tests were conducted to investigate the effect of pH and solid concentration on shear yield stress of suspensions while zeta potential measurements of suspensions were used to explain the rheology results. Rheology results indicated that single mineral experiments showed that 5 and 10 vol.% of quartz and hematite had no shear yield stress whereas the one of nickel oxide was positive value. Shear yield stress of nickel oxide–quartz mixture and nickel oxide–hematite mixtures increased as increasing pH and solid concentration, and the value was higher than the one obtained with only nickel oxide. These results obtained with two-mineral mixture systems were explained by electrokinetic properties of the minerals, i.e. zeta potential of the minerals. 相似文献
109.
Kaoru Abe Yasuhiro Sakurai Akira Okuyama Kazuhiro Sasaki Kei Tawarada 《Journal of the science of food and agriculture》2009,89(6):1097-1100
BACKGROUND: The behavior of cadmium in ecosystems needs to be monitored because of the human toxicity of this heavy metal. The need recently arose for a simple and quick on‐site test for trace levels of Cd in food and environmental samples. In response, an immunochromatographic assay kit for detecting Cd was manufactured by Kansai Electric Power Co. of Japan. This kit uses the antigen–antibody complex reaction between the Cd–EDTA complex and an anti‐Cd–EDTA antibody and shows the results in terms of the degree of color developed on a test paper. We previously reported the successful use of this kit to determine Cd concentrations in brown rice. Here, we applied the kit to the determination of Cd concentrations in rice foliage and soil. RESULTS: Cadmium in rice foliage was not extracted successfully by the method used for brown rice. However, it was successfully extracted by 0.1 mol L?1 HCl solution at a rice foliage:HCl ratio of 1:20, and coexisting metals were removed sufficiently by the column treatment. The Cd concentrations determined by immunochromatographic assay were well correlated with the values obtained by acid decomposition and inductively coupled plasma mass spectrometry. The 0.1 mol L?1 HCl‐extractable Cd concentration in soil was also determined successfully with the kit. CONCLUSION: Approximate Cd concentrations in rice plants and 0.1 mol L?1 HCl‐extractable Cd concentrations in soil can be monitored easily and quickly by this method at locations where facilities for acid digestion and precision analysis are not available. Copyright © 2009 Society of Chemical Industry 相似文献
110.
Saitoh M Asaka K Arai M Kawabata A Kanoh S Kanoh T 《Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan》2002,43(4):243-249
In order to evaluate the relationship between nasal carriers of S. aureus and their history of allergic diseases, the total serum IgE titer, the hemogramme pattern, and the titers of specific IgE antibody to Staphylococcal enterotoxins A and B (SEA and SEB) and of specific IgG antibody to SEB were investigated in 98 trade school students. Fifteen (15.3%) of the 98 students were sensitized to SEA and/or SEB (40.0% to SEA and 93.3% to SEB). In this group, 11 subjects were S. aureus carriers (73.0%) and 12 had a history of allergic diseases (80.0%). Low levels of specific IgG antibody to SEB were identified from both S. aureus carriers and non-carriers. The S. aureus carriers had significantly higher levels of total IgE titer than the non-carriers and the individuals with a history of allergic diseases had significantly higher total IgE titer levels than those having no history of allergic diseases (p < 0.01). In the hemogramme patterns of S. aureus carriers, a significant positive correlation was observed between the total IgE antibodies and the eosinophil rate (p < 0.05), and a negative correlation (p < 0.001) was recognized between the neutrophil and the lymphocyte rates. 相似文献