Understanding users and their needs

Gaze-control enables people to control a computer by using eye-gaze to select items on screen. Gaze-control is a necessity for people who have lost all motor control of their body and only have control over eye movements. In addition, gaze-control can be the quickest and least tiring option for a far broader group of people with varying disabilities. This paper reports findings from gaze-control user trials involving users from both groups: people who are totally paralyzed, as well as people with a wide range of complex disabilities. The trials conducted involved four different centres supporting people with disabilities in three different European countries. Several gaze-control systems were trialled by a large number of users with varying needs and abilities. The perceived benefits of gaze-control are described, and recommendations for successful assessment and implementation of gaze-control are provided.     

Global asymptotic stabilization of the attitude and the angular rates of an underactuated non-symmetric rigid body

The paper deals with the global stabilization of both the attitude and the angular velocities of an underactuated rigid body. First a stability theorem is proven for a class of systems; subsequently, the equations describing the physics of the rigid body are presented, showing that the rigid body belongs to the considered class of systems, and a sufficient condition for the application of the theorem to the stability of the rigid body equilibrium is pointed out. Finally, some simulation results are reported showing the effectiveness of the proposed methodology.     

Stabilizability of switched linear systems does not imply the existence of convex Lyapunov functions

Counterexamples are given which show that a linear switched system (with controlled switching) that can be stabilized by means of a suitable switching law does not necessarily admit a convex Lyapunov function. Both continuous- and discrete-time cases are considered. This fact contributes in focusing the difficulties encountered so far in the theory of stabilization of switched system. In particular the result is in contrast with the case of uncontrolled switching in which it is known that if a system is stable under arbitrary switching then admits a polyhedral norm as a Lyapunov function.     

Immersive and desktop virtual reality in virtual fashion stores: a comparison between shopping experiences

Virtual Reality - With the high growth and prosperity of e-commerce, the retail industry needs to explore new technologies that improve digital shopping experiences. In the current technological...     

A model of checkpoint behavior for applications that have I/O

Due to the increase and complexity of computer systems, reducing the overhead of fault tolerance techniques has become important in recent years. One technique in fault tolerance is checkpointing, which saves a snapshot with the information that has been computed up to a specific moment, suspending the execution of the application, consuming I/O resources and network bandwidth. Characterizing the files that are generated when performing the checkpoint of a parallel application is useful to determine the resources consumed and their impact on the I/O system. It is also important to characterize the application that performs checkpoints, and one of these characteristics is whether the application does I/O. In this paper, we present a model of checkpoint behavior for parallel applications that performs I/O; this depends on the application and on other factors such as the number of processes, the mapping of processes and the type of I/O used. These characteristics will also influence scalability, the resources consumed and their impact on the IO system. Our model describes the behavior of the checkpoint size based on the characteristics of the system and the type (or model) of I/O used, such as the number I/O aggregator processes, the buffering size utilized by the two-phase I/O optimization technique and components of collective file I/O operations. The BT benchmark and FLASH I/O are analyzed under different configurations of aggregator processes and buffer size to explain our approach. The model can be useful when selecting what type of checkpoint configuration is more appropriate according to the applications’ characteristics and resources available. Thus, the user will be able to know how much storage space the checkpoint consumes and how much the application consumes, in order to establish policies that help improve the distribution of resources.

     

Generation and interpretation of parsimonious predictive models for load forecasting in smart heating networks

Applied Intelligence - Forecasting future heat load in smart district heating networks is a key problem for utility companies that need such predictions for optimizing their operational activities....     

Ethyl oleate ozonide as an epoxidation tool of C60 and C70 fullerenes

When dissolved in ethyl oleate secondary ozonide, both C₆₀ and C₇₀ fullerenes undergo a series of epoxidation reactions. The pseudofirst-order kinetic rate constants of this process were determined spectrophotometrically at various temperatures and the activation energy for C₆₀ epoxidation through ethyl oleate ozonide was found at 25.9 kcal/mol. Furthermore, C₆₀ was found more reactive than C₇₀ with the ozonide. The kinetics rate constants of C₆₀ epoxidation with ethyl oleate ozonide were compared with the C₆₀ photo-oxidation and auto-oxidation determined in pure ethyl oleate. The epoxidation of fullerenes starts from the homolysis of the peroxide group of the 1,2,4-trioxolane ring of ethyl oleate secondary ozonide. Thus, it is suggested that fullerenes have a potential as decomposition agents of secondary ozonides in some technological applications.     

Sorafenib delivery nanoplatform based on superparamagnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

Currently,sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients.Unfortunately,its side effects,particularly its overall toxicity,limit the therapeutic response that can be achieved.Superparamagnetic iron oxide nanoparticles (SPIONs) are very attractive for drug delivery because they can be targeted to specific sites in the body through application of a magnetic field,thus improving intratumoral accumulation and reducing adverse effects.Here,nanoformulations based on polyethylene glycol modified phospholipid micelles,loaded with both SPIONs and sorafenib,were successfully prepared and thoroughly investigated by complementary techniques.This nanovector system provided effective drug delivery,had an average hydrodynamic diameter of about 125 nm,had good stability in aqueous medium,and allowed controlled drug loading.Magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle.An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver.Human hepatocellular carcinoma (HepG2) cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the superparamagnetic micelles loaded with sorafenib.These experiments demonstrated that this delivery platform is able to enhance sorafenib's antitumor effectiveness by magnetic targeting.The magnetic nanovectors described here represent promising candidates for targeting specific hepatic tumor sites,where selective release of sorafenib can improve its efficacy and safety profile.     

Velocity‐based formulations for standard and quasi‐incompressible hypoelastic‐plastic solids

We present three velocity‐based updated Lagrangian formulations for standard and quasi‐incompressible hypoelastic‐plastic solids. Three low‐order finite elements are derived and tested for non‐linear solid mechanics problems. The so‐called V‐element is based on a standard velocity approach, while a mixed velocity–pressure formulation is used for the VP and the VPS elements. The two‐field problem is solved via a two‐step Gauss–Seidel partitioned iterative scheme. First, the momentum equations are solved in terms of velocity increments, as for the V‐element. Then, the constitutive relation for the pressure is solved using the updated velocities obtained at the previous step. For the VPS‐element, the formulation is stabilized using the finite calculus method in order to solve problems involving quasi‐incompressible materials. All the solid elements are validated by solving two‐dimensional and three‐dimensional benchmark problems in statics as in dynamics. Copyright © 2016 John Wiley & Sons, Ltd.