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131.
The potential of Botanic Gardens (BGs) to contribute to environmental education is well documented. To what degree this potential is met concerning school students’ environmental education is to be considered. In Greece, Environmental Education Centres (EECs) develop Environmental Education Programmes (EEPs) for schools to implement. A questionnaire survey addressing teachers employed at the EECs in Greece investigated the use of BGs as a means of environmental education and identified their most important features in supporting school EEPs. Findings indicated that the majority of EEC teachers (90.6%) have not developed EEPs involving the use of BGs, although BGs were ranked as most suitable amongst other green spaces for conducting such programmes, particularly for primary school students. Teachers identified the need for BGs to be designed accordingly and provide the necessary infrastructure to be educationally effective that included facilitating teaching (e.g. open spaces, areas to congregate, easy access paths and indoor facilities) and plant-orientated elements as well as plant management displays. A strategy by BGs to promote their role in environmental education and a multidisciplinary design approach would maximise student benefit.  相似文献   
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Water Resources Management - In regulated industries it is important to identify appropriate performance benchmarks to incentivize companies’ performance. This study applies a stochastic...  相似文献   
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Nanoconfinement is a promising strategy in chemistry enabling increased reaction rates, enhanced selectivity, and stabilized reactive species. Sulfur's abundance and highly reversible two-electron transfer mechanism have fueled research on sulfur-based electrochemical energy storage. However, the formation of soluble polysulfides, poor reaction kinetics, and low sulfur utilization are current bottlenecks for broader practical application. Herein, a novel strategy is proposed to confine sulfur species in a nanostructured hybrid sulfur-carbon material. A microporous sulfur-rich carbon is produced from sustainable natural precursors via inverse vulcanization and condensation. The material exhibits a unique structure with sulfur anchored to the conductive carbon matrix and physically confined in ultra-micropores. The structure promotes Na+ ion transport through micropores and electron transport through the carbon matrix, while effectively immobilizing sulfur species in the nanoconfined environment, fostering a quasi-solid-state redox reaction with sodium. This translates to ≈99% utilization of the 2e− reduction of sulfur and the highest reported capacity for a room temperature Na−S electrochemical system, with high rate capability, coulombic efficiency, and long-term stability. This study offers an innovative approach toward understanding the key physicochemical properties of sulfurcarbon nanohybrid materials, enabling the development of high-performance cathode materials for room-temperature Na-S batteries with efficient sulfur utilization.  相似文献   
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ABSTRACT

Estimating productivity change and its determinants is of great importance when measuring the performance of a firm. A true random effect cost model was employed to measure the cost efficiency of water companies in England and Wales from 1993 to 2016. Subsequently, total factor productivity change was estimated and decomposed into cost-efficiency change, technical change, scale efficiency change, output effect and residual price effect. The results indicate that the English and Welsh water industry increased its productivity over the period examined at a rate of about 2.1%, and it was influenced primarily by technical change. The price reviews appear to have a positive impact on the productivity of water-only companies during the whole period examined. In the case of water and sewerage companies, the 1994 and 1999 price reviews had a positive impact on productivity, whereas the last two price reviews had an adverse impact.  相似文献   
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Gynecological cancers represent some of the most common types of malignancy worldwide. Erythropoietin-producing hepatocellular receptors (EPHs) comprise the largest subfamily of receptor tyrosine kinases, binding membrane-bound proteins called ephrins. EPHs/ephrins exhibit widespread expression in different cell types, playing an important role in carcinogenesis. The aim of the current review was to examine the dysregulation of the EPH/ephrin system in gynecological cancer, clarifying its role in ovarian, endometrial, and cervical carcinogenesis. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The search terms ephrin, ephrin receptor, ovarian cancer, endometrial cancer, and cervical cancer were employed and we were able to identify 57 studies focused on gynecological cancer and published between 2001 and 2021. All researched ephrins seemed to be upregulated in gynecological cancer, whereas EPHs showed either significant overexpression or extensive loss of expression in gynecological tumors, depending on the particular receptor. EPHA2, the most extensively studied EPH in ovarian cancer, exhibited overexpression both in ovarian carcinoma cell lines and patient tissue samples, while EPHB4 was found to be upregulated in endometrial cancer in a series of studies. EPHs/ephrins were shown to exert their role in different stages of gynecological cancer and to influence various clinicopathological parameters. The analysis of patients’ gynecological cancer tissue samples, most importantly, revealed the significant role of the EPH/ephrin system in the development and progression of gynecological cancer, as well as overall patient survival. In conclusion, the EPH/ephrin system represents a large family of biomolecules with promising applications in the fields of diagnosis, prognosis, disease monitoring, and treatment of gynecological cancer, with an established important clinical impact.  相似文献   
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The EPH/ephrin system constitutes a bidirectional signaling pathway comprised of a family of tyrosine kinase receptors in tandem with their plasma membrane-bound ligand (ephrins). Its significance in a wide variety of physiologic and pathologic processes has been recognized during the past decades. In carcinogenesis, EPH/ephrins coordinate a wide spectrum of pathologic processes, such as angiogenesis, vessel infiltration, and metastasis. Despite the recent advances in colorectal cancer (CRC) diagnosis and treatment, it remains a leading cause of death globally, accounting for 9.2% of all cancer deaths. A growing body of literature has been published lately revitalizing our scientific interest towards the role of EPH/ephrins in pathogenesis and the treatment of CRC. The aim of the present review is to present the recent CRC data which might lead to clinical practice changes in the future.  相似文献   
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Predicting what drivers will do as vehicle control is handed over to them from automation is a relatively new challenge for the motor vehicle industry. Operator Event Sequence Diagrams (OESDs) offer a way of modeling the interactions between the driver and vehicle automation in the handover of control. In this paper, two studies are presented in which a range of handover strategies are tested. The anticipated driver strategies were modeled using OESDs to serve as predictions of driver behavior. Drivers were then observed in two separate studies: (1) using a Lower-Fidelity (vehicle seat and controls) simulator and (2) using a Higher-Fidelity (whole vehicle) simulator. Driver behavior during a takeover task was categorized according to the signal detection paradigm into hits, misses, false alarms, and correct rejections. The results showed that for all strategies in both sets of studies, the median criterion for validity was exceeded ( > 0.8), suggesting that OESDs made good predictions of driver behavior during the handover of the vehicle from automation to manual control.  相似文献   
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Temperature and pH responsive poly(N‐isopropylacrylamide‐co‐methacrylic acid) (P(NIPAAm‐co‐MAA)) microcontainers with encapsulated magnetic nanoparticles in the shell were prepared by a two‐stage distillation precipitation polymerization. PMAA@Fe3O4/P(NIPAAm‐co‐MAA) core–shell nanoparticles were synthesized by the second‐stage polymerization of NIPAAm, MAA and N, N′‐methylenebisacrylamide as crosslinker in the presence of magnetic nanoparticles and PMAA as core. These novel triple‐functional microcontainers were prepared by selective removal of the PMAA core in water. Daunorubicin hydrochloride (DNR) was loaded into the microcontainers and the release profile was studied by UV–visible spectroscopy. The synthesized nanostructures were characterized with transmission and scanning electron microscopy, X‐ray diffraction and Fourier transform infrared spectroscopy. The magnetic properties were evaluated by vibrating sample magnetometry. The shrink and swelling behavior was studied by dynamic light scattering. Copyright © 2012 Society of Chemical Industry  相似文献   
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