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Benthic macroinvertebrates, sediment copper, and sediment particle size were examined in two areas of the Keweenaw Waterway. The north area is downdrift from deposits of copper tailings. South area sediment averaged 27% silt and clay and north area sediment 66%. South area sediment had an average copper content of 33 mg/kg and north area sediment 589 mg/kg. The number of invertebrates was 4.3 times greater in the south than the north. The average number of taxa at south stations was 20 and at north stations 8. Mollusks, mayflies, and crustaceans were common in the south but rare or absent in the north. Hexagenia was the most abundant animal in the south. A single individual was found in the north, at the only north station with low sediment copper. Three north stations with sediment particle size similar to south stations had the same restricted fauna of chironomids and oligochaetes as that found at other north stations. Equitability and Shannon-Wiener diversity values for most north stations did not indicate pollution because of the extremely low, and thus, even numbers of individuals collected in all taxa. Twenty-six taxa were common to both areas. Four taxa, found only in the north, were represented by five individuals. Twenty-five taxa, found only in the south, were represented by 1,007 individuals. The likely cause of the reduced invertebrate fauna in the north area is high levels of sediment copper.  相似文献   
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Biomaterial-induced thrombosis remains one of the main complications of vascular implant devices. Preadsorbed proteins on the biomaterial/blood interface will modify the adhesion and activation of platelets (PTLs) during the initial contact-phase. Our results clearly show that PTL-adherence on biomaterials is influenced not only by protein preadsorption, but also by flow conditions. The covalent coating of TCPS and glass by phosphorylcholine (PC) induces a significant decrease of PTL adhesion but leads to a slight, but nevertheless significant activation of PTL, which was detected by the induction of P-selectin expression using FACS analysis. Methodologically, the visualization of PTL adhesion gave more reliable results for measurement of PTL adhesion than the cell-enzyme immunoassay (EIA) for P-selectin. Human citrated plasma caused an inhibition of PTL. It is probable, that the contained sodium citrate may inhibit PTL adhesion by its calcium ion-binding capacity. The flow experiment as dynamic system is in our view absolutely essential for the evaluation of biomaterials for vascular prosthesis, and is in accordance with the international standards. The results of the experiments also suggest that investigations under static and flow conditions are needed to determine the influence of protein adsorption on mixed blood cell populations, for example, on PTL and PMN mixtures/co-cultures in order to achieve a better simulation of the in vivo situation.  相似文献   
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Ohne Zusammenfassung Für die finanzielle F?rderung der Arbeit aus ERP-Mitteln des Senats von Berlin wird besonders gedankt.  相似文献   
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Ultrasonic Doppler color imaging can provide anatomic information and simultaneously render flow information within blood vessels for diagnostic purpose. Many researchers are currently developing ultrasound image processing algorithms in order to provide physicians with accurate clinical parameters from the images. Because researchers use a variety of computer languages and work on different computer platforms to implement their algorithms, it is difficult for other researchers and physicians to access those programs. A system has been developed using World Wide Web (WWW) technologies and HTTP communication protocols to publish our ultrasonic Angle Independent Doppler Color Image (AIDCI) processing algorithm and several general measurement tools on the Internet, where authorized researchers and physicians can easily access the program using web browsers to carry out remote analysis of their local ultrasonic images or images provided from the database. In order to overcome potential incompatibility between programs and users' computer platforms, ActiveX technology was used in this project. The technique developed may also be used for other research fields.  相似文献   
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A sub-sea deployable fiber-optic sensor system for the continuous determination of a range of environmentally relevant volatile organic compounds in seawater has been developed. The prototype of a robust, miniaturized Fourier transform infrared (FT-IR) spectrometer for in situ underwater pollution monitoring was designed, developed, and built in our research group. The assembled instrument is enclosed in a sealed aluminium pressure vessel and is capable of maintenance-free operation in an oceanic environment down to depths of at least 300 m. The whole system can be incorporated either in a tow frame or a remotely operated vehicle (ROV). A suitable fiber-optic sensor head was developed, optimized in terms of sensitivity and hydrodynamics, and connected to the underwater FT-IR spectrometer. Due to a modular system design, various other sensor head configurations could be realized and tested, ensuring facile adaptation of the instrument to future tasks. The sensor system was characterized in a series of laboratory and simulated field tests. The sensor proved to be capable of quantitatively detecting a range of chlorinated hydrocarbons and monocyclic aromatic hydrocarbons in seawater down to the low ppb (microg/L) concentration range, including mixtures of up to 6 components. It has been demonstrated that varying amounts of salinity, turbidity, or humic acids, as well as interfering seawater pollutants, such as aliphatic hydrocarbons or phenols, do not significantly influence the sensor characteristics. In addition, the sensor exhibits sufficient long-time stability and a low susceptibility to sensor fouling.  相似文献   
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This paper reports on progress on the feasibility of fabricating molds for electroplating of medium-to-high aspect ratio structures (up to 5) using SPR 220-7 positive photoresist, commercialized by Shipley [1, 2]. We used this photoresist as an alternative to SU-8 negative epoxy-based photoresist, which is very difficult to process and remove after electroplating [3, 4]. SPR 220-7 is easy to work with and can be used as a sacrificial layer if removed after processing. A single layer of SPR 220-7 was deposited by spin coating up to 18 m thickness. Thicker layers (34–54 m) can be achieved with multi-layer coating/baking steps using a manual spin coater and oven. The motivation of this work is to realize micromachined high-density current-carrying wires for atom guides [5, 6]. However, the process can be used for a variety of applications such as on-chip inductors and microtransformers.  相似文献   
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A novel signal processing concept for X-ray imaging with directly converting pixelated semiconductor sensors is presented. The novelty of this approach compared to existing concepts is the combination of charge integration and photon counting in every single pixel. Simultaneous operation of both signal processing chains extends the dynamic range beyond the limits of the individual schemes and allows determination of the mean photon energy. Medical applications such as X-ray computed tomography can benefit from this additional spectral information through improved contrast and the ability to determine the hardening of the tube spectrum due to attenuation by the scanned object. A prototype chip in 0.35-micrometer technology has been successfully tested. The pixel electronics are designed using a low-swing differential current mode logic. Key element is a configurable feedback circuit for the charge sensitive amplifier which provides continuous reset, leakage current compensation and replicates the input signal for the integrator. This paper will discuss measurement results of the prototype structures and give details on the circuit design  相似文献   
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