Radiotherapy is identified as a crucial treatment for patients with glioblastoma, but recurrence is inevitable. The efficacy of radiotherapy is severely hampered partially due to the tumor evolution. Growing evidence suggests that proneural glioma stem cells can acquire mesenchymal features coupled with increased radioresistance. Thus, a better understanding of mechanisms underlying tumor subclonal evolution may develop new strategies. Herein, data highlighting a positive correlation between the accumulation of macrophage in the glioblastoma microenvironment after irradiation and mesenchymal transdifferentiation in glioblastoma are presented. Mechanistically, elevated production of inflammatory cytokines released by macrophages promotes mesenchymal transition in an NF-κB-dependent manner. Hence, rationally designed macrophage membrane-coated porous mesoporous silica nanoparticles (MMNs) in which therapeutic anti-NF-κB peptides are loaded for enhancing radiotherapy of glioblastoma are constructed. The combination of MMNs and fractionated irradiation results in the blockage of tumor evolution and therapy resistance in glioblastoma-bearing mice. Intriguingly, the macrophage invasion across the blood-brain barrier is inhibited competitively by MMNs, suggesting that these nanoparticles can fundamentally halt the evolution of radioresistant clones. Taken together, the biomimetic MMNs represent a promising strategy that prevents mesenchymal transition and improves therapeutic response to irradiation as well as overall survival in patients with glioblastoma. 相似文献
The heavy reliance on data is one of the major reasons that currently limit the development of deep learning. Data quality directly dominates the effect of deep learning models, and the long-tailed distribution is one of the factors affecting data quality. The long-tailed phenomenon is prevalent due to the prevalence of power law in nature. In this case, the performance of deep learning models is often dominated by the head classes while the learning of the tail classes is severely underdeveloped. In order to learn adequately for all classes, many researchers have studied and preliminarily addressed the long-tailed problem. In this survey, we focus on the problems caused by long-tailed data distribution, sort out the representative long-tailed visual recognition datasets and summarize some mainstream long-tailed studies. Specifically, we summarize these studies into ten categories from the perspective of representation learning, and outline the highlights and limitations of each category. Besides, we have studied four quantitative metrics for evaluating the imbalance, and suggest using the Gini coefficient to evaluate the long-tailedness of a dataset. Based on the Gini coefficient, we quantitatively study 20 widely-used and large-scale visual datasets proposed in the last decade, and find that the long-tailed phenomenon is widespread and has not been fully studied. Finally, we provide several future directions for the development of long-tailed learning to provide more ideas for readers.
Up to now, it is still an open question of how to construct a chosen-ciphertext secure unidirectional proxy re-encryption scheme in the adaptive corruption model. To address this problem, we propose a new unidirectional proxy re-encryption scheme, and prove its chosen-ciphertext security in the adaptive corruption model without random oracles. Compared with the best known unidirectional proxy re-encryption scheme proposed by Libert and Vergnaud in PKC’08, our scheme enjoys the advantages of both higher effi... 相似文献
In this work, we aim to discover real-world events from Flickr data by devising a three-stage event detection framework. In the first stage, a multimodal fusion (MF) model is designed to deal with the heterogeneous feature modalities possessed by the user-shared data, which is advantageous in computation complexity. In the second stage, a dual graph regularized non-negative matrix factorization (DGNMF) model is proposed to learn compact feature representations. DGNMF incorporates Laplacian regularization terms for the data graph and base graph into the objective, keeping the geometry structures underlying the data samples and dictionary bases simultaneously. In the third stage, hybrid clustering algorithms are applied seamlessly to discover event clusters. Extensive experiments conducted on the real-world dataset reveal the MF-DGNMF-based approaches outperform the baselines. 相似文献
Structural and Multidisciplinary Optimization - Light weight and crashworthiness signify two main challenges facing in vehicle industry, which often conflict with each other. In order to achieve... 相似文献