全文获取类型
收费全文 | 1255篇 |
免费 | 95篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 3篇 |
化学工业 | 421篇 |
金属工艺 | 8篇 |
机械仪表 | 25篇 |
建筑科学 | 45篇 |
矿业工程 | 5篇 |
能源动力 | 27篇 |
轻工业 | 391篇 |
水利工程 | 12篇 |
石油天然气 | 12篇 |
无线电 | 67篇 |
一般工业技术 | 138篇 |
冶金工业 | 83篇 |
原子能技术 | 4篇 |
自动化技术 | 111篇 |
出版年
2024年 | 4篇 |
2023年 | 16篇 |
2022年 | 80篇 |
2021年 | 93篇 |
2020年 | 27篇 |
2019年 | 53篇 |
2018年 | 44篇 |
2017年 | 46篇 |
2016年 | 52篇 |
2015年 | 47篇 |
2014年 | 59篇 |
2013年 | 85篇 |
2012年 | 94篇 |
2011年 | 95篇 |
2010年 | 67篇 |
2009年 | 52篇 |
2008年 | 72篇 |
2007年 | 62篇 |
2006年 | 52篇 |
2005年 | 39篇 |
2004年 | 35篇 |
2003年 | 28篇 |
2002年 | 21篇 |
2001年 | 12篇 |
2000年 | 11篇 |
1999年 | 6篇 |
1998年 | 25篇 |
1997年 | 19篇 |
1996年 | 9篇 |
1995年 | 6篇 |
1994年 | 8篇 |
1993年 | 8篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 4篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1971年 | 1篇 |
排序方式: 共有1352条查询结果,搜索用时 15 毫秒
21.
The study is focused on the external and internal mass transfers of lipids during their biodegradation process in a bioreactor with stationary basket bed of immobilized Bacillus spp. cells. By means of the lipid mass balance for a single particle of biocatalyst, considering the kinetic model adapted for the immobilized bacterial cells, specific mathematical models have been developed to estimate their mass flows in the liquid boundary layer surrounding the particle and inside the particle. The values of mass flows are significantly influenced by the internal diffusion velocity of lipids and the rate of their consumption, but also by the position inside the basket bed. These influences accumulated led to the appearance of a biological inactive region near the particle centre, its magnitude varying from 1.3 to 49.4% of the overall volume of particles. 相似文献
22.
Javier Murillo Beatriz López Víctor Muñoz Dídac Busquets 《Computational Intelligence》2012,28(1):24-50
Auctions have been used to deal with resource allocation in multiagent environments, especially in service‐oriented electronic markets. In this type of market, resources are perishable and auctions are repeated over time with the same or a very similar set of agents. In this scenario it is advisable to use recurrent auctions: a sequence of auctions of any kind where the result of one auction may influence the following one. Some problems do appear in these situations, as for instance, the bidder drop problem, the asymmetric balance of negotiation power or resource waste, which could cause the market to collapse. Fair mechanisms can be useful to minimize the effects of these problems. With this aim, we have analyzed four previous fair mechanisms under dynamic scenarios and we have proposed a new one that takes into account changes in the supply as well as the presence of alternative marketplaces. We experimentally show how the new mechanism presents a higher average performance under all simulated conditions, resulting in a higher profit for the auctioneer than with the previous ones, and in most cases avoiding the waste of resources. 相似文献
23.
Beatriz Maria Curtio Soares Carlos Alberto Rodrigues Anjos Taiane Bonfante Faria Sílvia Tondella Dantas 《Packaging Technology and Science》2016,29(1):65-73
The objectives of this study were to evaluate the characteristics of commercial soft drinks related with the corrosion process of the aluminium packaging and based on that, propose model solutions for future studies of beverage/package interaction and corrosion process of metal packages. Therefore, the pH, acidity, concentration of chlorides and copper in six types of soft drinks were determined, as well as the corrosion potential of the aluminium and the current density corrosion obtained in polarization curves using the beverages as electrolyte. Based on the results obtained, a solution of citric acid (pH = 3) containing chloride (250 mg/kg) and copper ions (250 µg/kg) is proposed. The obtained results are potentially useful for the industry and future studies regarding the interaction process between soft drinks and aluminium cans. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
24.
Ana Piar-Gutierrez Cristina García-Fontana Beatriz García-Fontana Manuel Muoz-Torres 《International journal of molecular sciences》2022,23(15)
Recent scientific evidence has shown an increased risk of fractures in patients with obesity, especially in those with a higher visceral adipose tissue content. This contradicts the old paradigm that obese patients were more protected than those with normal weight. Specifically, in older subjects in whom there is a redistribution of fat from subcutaneous adipose tissue to visceral adipose tissue and an infiltration of other tissues such as muscle with the consequent sarcopenia, obesity can accentuate the changes characteristic of this age group that predisposes to a greater risk of falls and fractures. Other factors that determine a greater risk in older subjects with obesity are chronic proinflammatory status, altered adipokine secretion, vitamin D deficiency, insulin resistance and reduced mobility. On the other hand, diagnostic tests may be influenced by obesity and its comorbidities as well as by body composition, and risk scales may underestimate the risk of fractures in these patients. Weight loss with physical activity programs and cessation of high-fat diets may reduce the risk. Finally, more research is needed on the efficacy of anti-osteoporotic treatments in obese patients. 相似文献
25.
Thamires Rodrigues de Sousa Beatriz Oliveira Fagundes Andrezza Nascimento Lorena Abreu Fernandes Fbio da Ressureio Sgnotto Raquel Leo Orfali Valria Aoki Alberto Jos da Silva Duarte Sabri Saeed Sanabani Jefferson Russo Victor 《International journal of molecular sciences》2022,23(12)
Atopic dermatitis (AD) is a common relapsing inflammatory skin disorder characterized by immune-mediated inflammation and epidermal barrier dysfunction. The pathogenesis of AD is multifactorial and has not been fully elucidated to date. This study aimed to evaluate whether serum IgG from adult AD patients could modulate the thymic maturation of IL-22-producing T cells and CLA+ T cells of non-atopic infants. Given that miRNAs regulate immune response genes, we evaluated whether miRNA expression is also altered in cultured thymocytes. Thymocytes were cultured with purified IgG from AD patients or control conditions (mock, Intravenous-IgG (IVIg), non-atopic IgG, or atopic non-AD IgG). Using flow cytometry analysis, we assessed the expression of CLA and intracellular levels of IL-4, IFN-γ, and IL-22 on double-positive T cells (DP T), CD4 T cells, or CD8 T cells. We also investigated the frequency of IgG isotypes and their direct interaction with the thymic T cells membrane. The miRNA profiles were evaluated by the Illumina small RNA-seq approach. MiRNA target gene prediction and enrichment analyses were performed using bioinformatics. Increased frequencies of IL-22 and CLA+ producing CD4+ T cells cultured with IgG of AD patients was seen in non-atopic infant thymocytes compared to all control conditions. No alterations were observed in the frequency of IgG isotypes among evaluated IgG pools. Evidence for a direct interaction between IgG and thymic DP T, CD4 T, and CD8 T cells is presented. The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR-342-3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). The prediction of the targetome of the seven dysregulated miRNAs between AD and mock control revealed 122 putative targets, and functional and pathway enrichment analyses were performed. Our results enhance our understanding of the mechanism by which IgG can collaborate in thymic T cells in the setting of infant AD. 相似文献
26.
Ana Beatriz Aguiar Sanford Leidivan Sousa da Cunha Caio Bezerra Machado Flvia Melo Cunha de Pinho Pessoa Abigail Nayara dos Santos Silva Rodrigo Monteiro Ribeiro Fabiano Cordeiro Moreira Manoel Odorico de Moraes Filho Maria Elisabete Amaral de Moraes Lucas Eduardo Botelho de Souza Andr Salim Khayat Caroline Aquino Moreira-Nunes 《International journal of molecular sciences》2022,23(15)
The circadian clock (CC) is a daily system that regulates the oscillations of physiological processes and can respond to the external environment in order to maintain internal homeostasis. For the functioning of the CC, the clock genes (CG) act in different metabolic pathways through the clock-controlled genes (CCG), providing cellular regulation. The CC’s interruption can result in the development of different diseases, such as neurodegenerative and metabolic disorders, as well as cancer. Leukemias correspond to a group of malignancies of the blood and bone marrow that occur when alterations in normal cellular regulatory processes cause the uncontrolled proliferation of hematopoietic stem cells. This review aimed to associate a deregulated CC with the manifestation of leukemia, looking for possible pathways involving CG and their possible role as leukemic biomarkers. 相似文献
27.
Luana Beatriz dos Santos Nascimento Massimiliano Tattini 《International journal of molecular sciences》2022,23(9)
Plants evolved an impressive arsenal of multifunctional specialized metabolites to cope with the novel environmental pressures imposed by the terrestrial habitat when moving from water. Here we examine the multifarious roles of flavonoids in plant terrestrialization. We reason on the environmental drivers, other than the increase in UV-B radiation, that were mostly responsible for the rise of flavonoid metabolism and how flavonoids helped plants in land conquest. We are reasonably based on a nutrient-deficiency hypothesis for the replacement of mycosporine-like amino acids, typical of streptophytic algae, with the flavonoid metabolism during the water-to-land transition. We suggest that flavonoids modulated auxin transport and signaling and promoted the symbiosis between plants and fungi (e.g., arbuscular mycorrhizal, AM), a central event for the conquest of land by plants. AM improved the ability of early plants to take up nutrients and water from highly impoverished soils. We offer evidence that flavonoids equipped early land plants with highly versatile “defense compounds”, essential for the new set of abiotic and biotic stressors imposed by the terrestrial environment. We conclude that flavonoids have been multifunctional since the appearance of plants on land, not only acting as UV filters but especially improving both nutrient acquisition and biotic stress defense. 相似文献
28.
Claudio Bernardazzi Morgana Teixeira Lima Castelo-Branco Beatriz Pêgo Beatriz Elias Ribeiro Siane Lopes Bittencourt Rosas Patrícia Teixeira Santana Joo Carlos Machado Camille Leal Fabiano Thompson Robson Coutinho-Silva Heitor Siffert Pereira de Souza 《International journal of molecular sciences》2022,23(9)
29.
30.
Characterisation of chickpea flour‐based gluten‐free batters and muffins with added biopolymers: rheological,physical and sensory properties 下载免费PDF全文
Beatriz Herranz Wenceslao Canet María José Jiménez Raúl Fuentes María Dolores Alvarez 《International Journal of Food Science & Technology》2016,51(5):1087-1098
Chickpea flour (CF)‐based muffin formulations were made with CF alone and with added biopolymers [whey protein (WP), xanthan gum (XG) and inulin (INL)] to evaluate their suitability to be a wheat flour (WF) substitute in muffins. Structural characteristics of the batters and muffins were studied by means of rheometry, microscopy, physicochemical properties, and texture and sensory analysis. Partial replacement of CF with XG, alone (at 0.5 and 1%) or blended with either WP or INL, significantly increased the batter viscoelasticity as denser matrices developed; moreover, the muffins with XG added at 1% had similar hardness to wheat gluten muffins. The replacement of WF decreased the springiness, cohesiveness, chewiness, resilience and specific volume of the muffin. However, baked muffins with added XG also showed higher sensory sponginess and moisture associated with numerous air bubbles in the batter and were perceived to be easier to swallow and to have better general appearance. 相似文献