Ion-Pairing of Dyclonine with Dyes

This potential for ion-pairing between dyclonine, a local anesthetic, and pharmaceutical dyes commonly used in liquid pharmaceutical formulations was examined. Occurrence of ion-pairing at a pH of 3 was confirmed by shift of the absorption maximum of all five sulfonate-containing dyes, and by measurements of octanol/water partition coefficient and surface tension. There was also an increase in the uptake of dyclonine by phosphatidylcholine liposomes in the presence of a dye (tartrazine) at pH 3 but not at pH 7, where the uncharged anesthetic is dominant.     

On the design of multiple key hashing files for concurrent orthogonal range retrieval between two disks

This paper concerns the following problem: given a set of multi-attribute records, a fixed number of buckets and a two-disk system, arrange the records into the buckets and then store the buckets between the disks in such a way that, over all possible orthogonal range queries (ORQs), the disk access concurrency is maximized. We shall adopt the multiple key hashing (MKH) method for arranging records into buckets and use the disk modulo (DM) allocation method for storing buckets onto disks. Since the DM allocation method has been shown to be superior to any other allocation methods for allocating an MKH file onto a two-disk system for answering ORQs, the real issue is knowing how to determine an optimal way for organizing the records into buckets based upon the MKH concept.

A performance formula that can be used to evaluate the average response time, over all possible ORQs, of an MKH file in a two-disk system using the DM allocation method is first presented. Based upon this formula, it is shown that our design problem is related to a notoriously difficult problem, namely the Prime Number Problem. Then a performance lower bound and an efficient algorithm for designing optimal MKH files in certain cases are presented. It is pointed out that in some cases the optimal MKH file for ORQs in a two-disk system using the DM allocation method is identical to the optimal MKH file for ORQs in a single-disk system and the optimal average response time in a two-disk system is slightly greater than one half of that in a single-disk system.     

Indexed in current contents

Indexed in current contents     

The origination and optimization of Si/SiO/sub 2/ interface roughness and its effect on CMOS performance

As CMOS device dimensions scale down to 100 nm and beyond, the interface roughness between Si and SiO/sub 2/ has become critical to device performance and reliability. Si/SiO/sub 2/ interface roughness degrades channel mobility decreasing drive currents. The authors have used atomic force microscopy to study surface roughness in the processing of 0.16 /spl mu/m CMOS integrated circuits. All of the process steps that could potentially affect the interface roughness have been studied. The results show that oxidation is the major contributor to the interface roughness. The rms roughness is found to be linearly dependent on oxide thickness. Transistors with Si/SiO/sub 2/ interface rms roughness that has been reduced from 1.6 to 1.1 /spl Aring/ by reducing oxide thicknesses show improved device drive currents. This technique for interfacial smoothing and device performance improvement has the advantage of being easily implemented in today's technology.     

Application of the blind source separation method to feature extraction of machine sound signals

As the result of vibration emission in air, a machine sound signal carries important information about the working condition of machinery. But in practice, the sound signal is typically received with a very low signal-to-noise ratio. To obtain features of the original sound signal, uncorrelated sound signals must be removed and the wavelet coefficients related to fault condition must be retrieved. In this paper, the blind source separation technique is used to recover the wavelet coefficients of a monitored source from complex observed signals. Since in the proposed blind source separation (BSS) algorithms it is generally assumed that the number of sources is known, the Gerschgorin disk estimator method is introduced to determine the number of sound sources before applying the BSS method. This method can estimate the number of sound sources under non-Gaussian and non-white noise conditions. Then, the partial singular value analysis method is used to select these significant observations for BSS analysis. This method ensures that signals are separated with the smallest distortion. Afterwards, the time-frequency separation algorithm, converted to a suitable BSS algorithm for the separation of a non-stationary signal, is introduced. The transfer channel between observations and sources and the wavelet coefficients of the source signals can be blindly identified via this algorithm. The reconstructed wavelet coefficients can be used for diagnosis. Finally, the separation results obtained from the observed signals recorded in a semi-anechoic chamber demonstrate the effectiveness of the presented methods .     

Transformations in machining. Part 1. enhancement of wavelet transformation neural network (WT-NN) combination with a preprocessor

Properly selected transformation methods obtain the most significant characteristics of metal cutting data efficiently and simplify the classification. Wavelet Transformation (WT) and Neural Networks (NN) combination was used to classify the experimental cutting force data of milling operations previously. Preprocessing (PreP) of the approximation coefficients of the WT is proposed just before the classification by using the Adaptive Resonance Theory (ART2) type NNs. Genetic Algorithm (GA) was used to estimate the weights of each coefficient of the PreP. The WT-PreP-NN (ART2) combination worked at lower vigilances by creating only a few meaningful categories without any errors. The WT-NN (ART2) combination could obtain the same error rate only if very high vigilances are used and many categories are allowed.     

Nd3+ Doped Silicate Glass Photonic Crystal Fiber with Random Hole Distributions

The fabrication of one kind of large core area Nd3 doped silicate glass photonic crystal fiber, and demonstration of the fiber's waveguidence properties were reported. This fiber owns a random air hole distribution in the cladding. The measured minimum loss of this kind of fiber is 10 dB·m-1 at 660 nm. These fibers can sustain only a single mode at least over wavelength ranging from 660 nm to 980 nm.     

A Shortcut Method for Estimating the HETP of Structured Packed Distillation Columns at Elevated Pressure

A shortcut model is developed for predicting the HETP of a structured packed distillation column operating at elevated pressure. The proposed model incorporates the geometrical parameters of the packing, physical properties of the vapor and liquid phases, and the hydrodynamics of the two‐phase flow. The proposed model is tested and validated by comparing the predicted results with the present experimental data and some published HETP data. The results show that the proposed model can predict the experimental data with a deviation smaller than 20 %.     

Evaluation of accuracy of measuring intraocular pressure by handheld non-contact applanation tonometer

PURPOSE: To evaluate the accuracy of measuring intraocular pressure by handheld non-contact applanation tonometer. METHOD: 58 patients' (113 eyes) intraocular pressure were measured by Keeler, non-contact tonometer and R 900 Goldmann applanation tonometer and the results of measurement of intraocular pressure by the two kinds of tonometers were compared. RESULT: The mean intraocular pressure measured by non-contact is 16.31 +/- 5.59 mmHg and 17.49 +/- 6.13 mmHg (1 mmHg = 0.1333 kPa) by Goldmann applanation tonometer, respectively. There was no statistical significance to be found (P > 0.05) between the two methods. By linear correlation and regression analysis, a positive correlation was found between the two methods (r = 0.8942, b = 0.8154). CONCLUSION: The handheld non-contact tonometer has the same accuracy and reliability of measurement of intraocular pressure comparing with Goldmann applanation tonometer, and it can be used in glaucoma clinic and screening.