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91.
This paper shows how synchrony conditions can be added to the purely asynchronous model in a way that avoids any reference to message delays and computing step times, as well as system-wide constraints on execution patterns and network topology. Our Asynchronous Bounded-Cycle (ABC) model just bounds the ratio of the number of forward- and backward-oriented messages in certain (“relevant”) cycles in the space-time diagram of an asynchronous execution. We show that clock synchronization and lock-step rounds can be implemented and proved correct in the ABC model, even in the presence of Byzantine failures. Furthermore, we prove that any algorithm working correctly in the partially synchronous Θ-Model also works correctly in the ABC model. In our proof, we first apply a novel method for assigning certain message delays to asynchronous executions, which is based on a variant of Farkas’ theorem of linear inequalities and a non-standard cycle space of graphs. Using methods from point-set topology, we then prove that the existence of this delay assignment implies model indistinguishability for time-free safety and liveness properties. We also introduce several weaker variants of the ABC model, and relate our model to the existing partially synchronous system models, in particular, the classic models of Dwork, Lynch and Stockmayer and the query-response model by Mostefaoui, Mourgaya, and Raynal. Finally, we discuss some aspects of the ABC model’s applicability in real systems, in particular, in the context of VLSI Systems-on-Chip.  相似文献   
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93.
The rapidly growing field of neuroproteomics has expanded to track global proteomic changes underlying various neurological conditions such as traumatic brain injury (TBI), stroke, and Alzheimer's disease. TBI remains a major health problem with approximately 2?million incidents occurring annually in the United States, yet no affective treatment is available despite several clinical trials. The absence of brain injury diagnostic biomarkers was identified as a significant road-block to therapeutic development for brain injury. Recently, the field of neuroproteomics has undertaken major advances in the area of neurotrauma research, where several candidate markers have been identified and are being evaluated for their efficacy as biological biomarkers in the field of TBI. One scope of this review is to evaluate the current status of TBI biomarker discovery using neuroproteomics techniques, and at what stage we are at in their clinical validation. In addition, we will discuss the need for strengthening the role of systems biology and its application to the field of neuroproteomics due to its integral role in establishing a comprehensive understanding of specific brain disorder and brain function in general. Finally, to achieve true clinical input of these neuroproteomic findings, these putative biomarkers should be validated using preclinical and clinical samples and linked to clinical diagnostic assays including ELISA or other high-throughput assays.  相似文献   
94.
The electrical reflection coefficient r(e) and velocity shift (Deltanu/nu)(e) for grooves has never been formulated. All previous calculations for r(e) and (Deltanu/nu)(e) have used formulas valid for the reflection of a surface acoustic wave (SAW) from an array of conducting strips. However, the discontinuity in electrical boundary conditions leading to these formulas does not exist in groove gratings. A new expression for the electrical reflection coefficient and velocity shift for some material overlays is derived from both the variational principle and perturbation theory. The results for various substrates are compared to show the agreement between the two approaches. The implications of this new formulation for the design of grooved arrays on various materials are discussed, effectively resolving the discrepancy between theory and experiment.  相似文献   
95.
The stretch of the St. Lawrence River near Cornwall, Ontario, Canada, between the Moses–Saunders power dam to the eastern outlet of Lake St. Francis in Québec, is currently listed as an Area of Concern (AOC), and has restrictive fish consumption advisories in place, largely due to high mercury levels. This study examined long-term temporal trends of mercury concentrations in northern pike, smallmouth bass, walleye and yellow perch from the St. Lawrence River, including the Cornwall AOC. In addition, differences in fish mercury concentrations among river sections were compared for each species using historical (1975–1979) and recent (2000–2011) data. Statistically significant declines in mercury concentrations were observed in all river sections for yellow perch (~ 40%), as well as in northern pike and walleye in at least one river section. For the river section encompassing the AOC, recent mercury concentrations are 33–59% lower than historical mercury concentrations for all four species. Further, a comparison of recent mercury concentrations between the AOC river section and other Ontario lakes/rivers suggests that AOC mercury values are within the 75th percentile of values for other Ontario water bodies in three of the four species considered. However, current fish mercury values for the AOC river section remain higher than one or more upstream river sections. These results indicate that recovery is still ongoing in this AOC.  相似文献   
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97.
Evaluating water quality data for outliers is a good quality control/quality assessment procedure whether the data are used for monitoring or for modeling. Often water quality data are correlated, e.g., carbonaceous biochemical oxygen demand (CBOD) has some correlation with NH3. Univariate methods for identifying outliers do not consider the correlation between variables and may identify too many data points as outliers or miss observations which have extreme ratios between variables, e.g., a raw wastewater sample with relatively low CBOD but high NH3. Testing for outliers using multivariate methods such as the Mahalanobis distance, Jackknife distance, p-values, or Hadi’s automatically incorporates the correlation or covariance between variables and is fundamentally more correct. Such multivariate methods can better identify potential outliers and avoid eliminating valid data.  相似文献   
98.
The effects of serotonergic agonists were examined in intact and spinal fetuses, using an in vivo fetal rat preparation. On Gestational Day 20, fetuses were prepared with a midthoracic or sham spinal transection. Dose-response curves were obtained for quipazine (nonselective 5-hydroxytryptamine [5-HT] agonist; 1.0-10.0 mg/kg), CGS-12066A (5-HT1B agonist; 1.0-30.0 mg/kg), and α-methylserotonin (α-Me-5-HT; 5-HT? agonist; 0.2-15.0 mg/kg). During a 10-min test, each of the agonists (delivered via intraperitoneal injection) influenced fetal behavior: They increased the occurrence of head movements, mouthing, and hindlimb stepping. Quipazine and α-Me-5-HT also promoted hindlimb activity in spinal fetuses. Thus, stimulation of the fetal 5-HT system modulates motor activity at multiple levels of the developing central nervous system. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
99.
The keystroke dynamics of a computer user's login string provide a characteristic pattern that can be used for identity verification. Timing vectors for several hundred login attempts were collected for ten “valid” users and ten “forgers”, and classification analysis was applied to discriminate between them. Three different classifiers were applied, and in each case the key hold times were more effective features for discrimination than the interkey times. Best performance was achieved by an inductive learning classifier using both interkey and hold times. A high rate of typographical errors during login entry is reported. In practice, these are usually corrected errors-that is, they are strings which include backspaces to correct earlier errors-but their presence confounds the use of typing-style analysis as a practical means of securing access to computer systems  相似文献   
100.
以公共结构及语言进行应用系统一体化   总被引:1,自引:0,他引:1  
祝春捷 《浙江电力》2004,23(3):13-16
介绍了美国佛罗里达电力照明公司对主要业务系统基于公共结构及语言,进行信息集成的工作过程和经验,对企业信息一体化的技术内容和框架结构做了总体介绍,并根据应用实际阐述了公共信息模型的扩展,对其他企业开展信息系统一体化工作具有一定的借鉴作用.  相似文献   
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