Developmental pattern of fetal growth hormone, insulin-like growth factor I, growth hormone binding protein and insulin-like growth factor binding protein-3

AIMS: To evaluate the developmental pattern of fetal growth hormone (GH), insulin-like growth factor I (IGF-I), GH binding protein (GHBP) and IGF binding protein-3 (IGF-3); to determine the implications for fetal growth. METHODS: Serum GH, IGF-I, GHBP and IGFBP-3 were measured in 53 fetuses, 41 aged 20-26 weeks (group A) and 12 aged 31-38 weeks (group B). Fetal blood samples were obtained by direct puncture of the umbilical vein in utero. Fetal blood samples were taken to rule out beta thalassaemia, chromosome alterations, mother to fetus transmissible infections, and for maternal rhesus factor. GHBP was determined by gel filtration chromatography of serum incubated overnight with 125I-GH. GH, IGF-I and IGFBP-3 were determined by radioimmunoassay. RESULTS: Fetal serum GH concentrations in group A (median 29 micrograms/l, range 11-92) were significantly higher (P < 0.01) than those of group B (median 16.7 micrograms/l, range 4.5-29). IGF-I in group A (median 20 micrograms/l, range 4.1-53.3) was significantly lower (P < 0.01) than in group B (median 75.2 micrograms/l, range 27.8-122.3). Similarly, IGFBP-3 concentrations in group A (median 950 micrograms/l, range 580-1260) were significantly lower than those of group B (median 1920 micrograms/l, range 1070-1770). There was no significant difference between GHBP values in group A (median 8.6%, range 6.6-12.6) and group B (median 8.3%, range 6-14.3). Gestational age correlated positively with IGF-I concentrations (P < 0.0001) and IGFBP-3 (P < 0.0001) and negatively with GH (P < 0.0001). GHBP values did not correlate with gestational age. Multiple regression analysis showed a negative correlation between GH:IGF-I ratio and fetal growth indices CONCLUSIONS: The simultaneous evaluation of fetal GH, IGF-I, IGFBP-3 and GHBP suggests that the GH-IGF-I axis might already be functional in utero. The progressive improvement in the efficiency of this axis in the last part of gestation does not seem to be due to an increase in GH receptors.     

The morphology of rigid-rod polymers and molecular composites resulting from coagulation processing

The effects of processing conditions on the morphology of molecular composite films are examined by optical and electron microscopy. During coagulation processing from solutions in methanesulfonic acid (MSA), rigid-rod polymer, such as poly(p-phenylenebenzobisoxazole) (PBO), phase separates into undesirable aggregates. The coagulant and the method of its introduction have been found to exert a strong impact on the final film morphology. A quench of a PBO solution in MSA into a water bath results in a three dimensional interconnected network of PBO, while a slower introduction of water results in a more amorphous material. A computer simulation program of the coagulation process has been developed to better understand the different structures emerging from coagulation processing of molecular composites. The simulation results are in qualitative agreement with the experimental observations.     

Construction Productivity Improvement

Construction productivity has been on the decline in the last decade. The results are presented on a survey of the Engineering News‐Record 400 largest contractors to obtain their views on where productivity improvements would most help and to compare the trends with a similar survey carried out in 1979. Data were collected on the general company characteristics of the responding contractors, and on the contractors' opinions on potential areas for productivity improvement in the office and in the field. Findings indicate that immediate research should concentrate on improving marketing practices, planning and scheduling, labor‐management relations, site supervision, industrialized building systems, equipment policy and engineering design; and that governmental regulations have lost the immediate urgency attached to them in 1979.It is also recommended that similar surveys be conducted every 3 to 4 years to identify new trends and to steer research in the appropriate direction.     

Children's ascriptions of knowledge to others.

Piaget believed that young children were egocentric and would ascribe their own knowledge to another. In contrast, Wimmer, Hogrefe, and Perner (1988) found that children did not perform egocentrically when assessing another's knowledge. The present study was carried out to determine which claim was right. A familiar object was secretly placed in a box, and a child and others either looked in the box or did not look. Two of the main findings were that (a) 6-year-olds were significantly better than 3- to 4-year-olds at assessing the other's knowledge, even though both assessed the other's perception correctly (p?p?     

Sensory registration and informational persistence.

The view of iconic memory as a precategorical, high-capacity, quickly decaying visible memory has recently come under attack (e.g., M. Coltheart, 1980). Distinctions have been drawn between visible persistence, or the phenomenal trace of an extinguished stimulus, and informational persistence, knowledge about the visual properties of the stimulus. Two alternative conceptions of informational persistence were tested in 3 experiments with 13 university students and the present authors. One conception is that visual information persists in a visual memory that begins at stimulus offset and lasts for 150–300 msec, independently of exposure duration. The 2nd conception is that informational persistence arises from a nonvisual memory that contains spatial coordinates for displayed items along with identity codes for those items. In the experiments, 3?×?3 letter arrays were presented for durations ranging from 50 to 500 msec. A single character mask presented at varying intervals after array offset cued report of an entire row of the array. Comparison of the cued row's masked and unmasked letters revealed that spatially specific visual (i.e., maskable) information persisted after stimulus offset, regardless of exposure duration. This result favors the visual conception of informational persistence. There was also support, however, for the nonvisual conception: Accuracy increased and item intrusion errors decreased as stimulus duration increased. Implications for models of informational persistence and for transsaccadic integration during reading are discussed. (47 ref) (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Forgetting in rats following medial septum or mammillary body damage.

Examined the effects of medial septal (MS) and mammillary body (MB) radio-frequency lesions in an automated delayed-matching-to-sample (DMTS) procedure using lever-position stimuli and rats. Memory performance pre- and postsurgery was assessed with a negative exponential decay function fitted to bias-free measures of recognition. Part 1 showed that MS, but not MB or sham-control surgery, impaired DMTS performance. This impairment in the MS group was best characterized as an increase in the rate of forgetting. Part 2 examined the interaction between MS and MB lesion effects and proactive interference arising from responses made on the previous DMTS trial. The results indicated that proactive interference effects were similar for all groups. These results provide further support for the critical role of the MS region in memory function but indicate that damage to this brain region does not disrupt memory function through a heightened sensitivity to proactive interference. (PsycINFO Database Record (c) 2010 APA, all rights reserved)