Prostate cancer clinical trials of the Southwest Oncology Group

The changing clinical dynamics of prostate cancer have resulted in a broadening of the research focus of the Genitourinary (GU) Cancer Committee of the Southwest Oncology Group (SWOG). Beginning with an emphasis on hormone-refractory disease in its early years, SWOG prostate cancer trials now cover the entire spectrum of the disease: localized, locally advanced, metastatic and hormone-refractory disease. As the world's largest GU cancer research group, the GU committee of SWOG has pioneered studies in combined androgen therapy for metastatic disease, quality-of-life (QOL) assessments for patients with localized and advanced disease, adjuvant therapy models, and prostate cancer chemoprevention. The committee has also formed the GU Global Group, whose purpose is to convene the chairs of the GU committees of all the major national and international oncology cooperative groups. Meeting semiannually, this group discusses activities within their respective organizations, plans collaborative strategies and protocols, and establishes global strategy in prostate cancer clinical research. The future directions of national and international prostate cancer trials will build on this broad foundation of well-conceived, logically sequenced studies.     

Robotics in the factory of the future: AI in manufacturing: The NBS AMRF as an intelligent machine

Within its Automated Manufacturing Research Facility (AMRF), the U.S. National Bureau of Standards (NBS) is addressing research issues in interface standards for the fully automated factory of the future for the production of small batches of discrete parts. Consisting of robots, machine tools and computers, the AMRF is being integrated using a real-time, sensory-feedback, data-driven hierarchical control architecture. As such, the AMRF is a research tool for investigating the manufacturing enterprise as a system of intelligent machines. This paper: (1) describes the AMRF in terms of its real-time control system architecture; (2) notes the role of symbolic languages, knowledge-representation, sensory-processing and other aspects of artificial intelligence in its development; and (3) speculates on further application of AI in future intelligent manufacturing systems similar in form to the AMRF.     

Cognitive categorization and quality of performance ratings.

The effects of cognitive categorization of raters on accuracy, leniency, and halo of performance evaluations were investigated in a field setting. One hundered seventy-four subordinates evaluated the performance of their managers on three performance dimensions. Managers were categorized as congruent or incongruent based on subordinates' perceptions of the extent to which the manager's behavior met the subordinates' expectations. The results indicated that the quality of ratings assigned by subordinates was related to the cognitive categories used. As hypothesized, ratings of managers who were categorized as congruent were found to be more accurate and also to contain more leniency and halo tendency than the ratings of managers who were categorized as incongruent. Implications of these findings for performance-appraisal research are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A System for Three-Dimensional Interactive Simulation of Hand Biomechanics

A real-time interactive graphics simulation of the mechanics of the human thumb has been developed. The simulation utilizes a realistic data structure for the bones of the thumb which may be expanded to include the hand and forearm. This is coupled to a model of the kinematics of the joints in a concurrent processing arrangement in which the dynamic graphical transformations for scaling, translation, rotation, perspective, and clipping are all performed on a special-purpose display processor. The model and the control functions are distributed between this processor and a separate general-purpose superminicomputer. The resulting system presents the user with a realistic simulation of the movements of the thumb in normal and impaired states. The user may choose from a menu of options, including an interactive tendon transfer simulation for the current hand being simulated. He may control (interactively and in real time) the view, observation position, skeletal motion, and parameters for use in the model of joint mechanics. This type of computer modeling, utilizing a realistic three-dimensional data structure, models of musculoskeletal kinematics, and interactive programming, shows great potential for bringing mathematical modeling into useful clinical, research, and educational applications.     

Contingent suppression of tolerance to the "anorexigenic" effect of haloperidol.

Whether tolerance develops to the "anorexia" induced by haloperidol (HAL) was determined. Rats were given HAL (2.5 or 5 mg/kg) either before or after access to milk for 53 days. Controls were given injections of saline. On Day 54, when all groups received pretest injections of the drug, only rats previously given posttest injections of HAL were tolerant. The absence of tolerance in rats previously given pretest injections suggests that tolerance is suppressed when rats are given access to food in the drugged state. It is concluded that tolerance develops to HAL as a result of pharmacological exposure but is suppressed by the "anhedonic" effect of the drug. The relevance of these findings to the role of reinforcement in behavioral tolerance is briefly discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Structured Parallel Architecture for Displacement MIMO Kalman Equalizer in CDMA Systems

A reduced complexity MIMO Kalman equalizer architecture is proposed in this brief by jointly considering the displacement structure and the block-Toeplitz structure. Numerical matrix-matrix multiplications with O(F³) complexity are eliminated by simple data loading process, where F is the spreading factor. Finally, an iterative Conjugate-Gradient based algorithm is proposed to avoid the inverse of the Hermitian symmetric innovation covariance matrix in Kalman gain processor. The proposed architecture not only reduces the numerical complexity from O(F²) to O(Flog₂F) per chip, but also facilitates the parallel and pipelined VLSI implementation in real-time processing     

Overexpression of HER2 modulates bcl-2, bcl-XL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells

Overexpression of HER2 in estrogen receptor (ER)-positive human breast tumors has been associated with resistance to endocrine therapy. Here we investigated the effects of HER2 on expression of apoptotic pathways and modulation of tamoxifen-induced apoptosis in ER-positive MCF-7 breast cancer cells. We report that HER2 overexpression in MCF-7 cells is accompanied by up-regulation of antiapoptotic Bcl-2 and Bcl-XL proteins and suppression of tamoxifen-induced apoptosis. In addition, human tumor cell lines that are both ER positive and overexpress HER2 also express enhanced levels of Bcl-2 compared to cells that are either ER positive or overexpress HER2 alone. Our findings suggest that possible deregulation of antiapoptotic Bcl-2 and Bcl-XL may be associated with the enhanced survival of HER2-overexpressing and ER-positive breast cancer cells treated with antiestrogens.     

The development of a model to estimate the bistatic transmissionloss associated with intersystem interference

This paper presents a new method for evaluating transmission loss, which is a key factor used in determining the impact of interference between terrestrial radio relay systems and Earth-satellite systems operating at the same frequency. The current model used by the CCIR was developed in the early 1970's when system packing density was low and large earth station antennas allowed the consideration of narrow beam approximations, resulting in a small common volume of intersection of the two beams. The recent increase in microwave communications traffic and improvements in technology have meant that smaller earth station antennas, including very small aperture terminals (VSATs), can be employed and hence the model requires revision. Results from the new model proposed are compared with two experimental geometries and good agreement is found