Gold nanorods mediated controlled release of doxorubicin: nano-needles for efficient drug delivery

Use of cysteamine hydrochloride (Cys-HCl) protected gold nanorods (GNRs) as efficient carrier of widely used anti-cancer drug doxorubicin using folic acid as navigational molecule is presented in this work. GNRs were found to have excellent drug loading capacity of >97 %. A detailed comprehension of in vitro drug release profile under ideal physiological condition was found to obey 1st order kinetics at pH 6.8, 5.3 and 7.2, an ideal milieu for drug delivery to solid tumours.     

CNSL: an environment friendly alternative for the modern coating industry

Considering ecological and economical issues in the new generation coating industries, the maximum utilization of naturally occurring materials for polymer synthesis can be an obvious option. In the same line, one of the promising candidates for substituting partially, and to some extent totally, petroleum-based raw materials with an equivalent or even enhanced performance properties, is the Cashew Nut Shell Liquid (CNSL). This dark brown-colored viscous liquid obtained from shells of the cashew nut can be utilized for a number of polymerization reactions due to its reactive phenolic structure and a meta-substituted unsaturated aliphatic chain. Therefore, a wide variety of resins can be synthesized from CNSL, such as polyesters, phenolic resins, epoxy resins, polyurethanes, acrylics, vinyl, alkyds, etc. The present article discusses the potential of CNSL and its derivatives as an environment friendly alternative for petroleum-based raw materials as far as polymer and coating industries are concerned.     

The outlook of zeolite-Y hampered metal–ligand framework as heterogeneous catalysts: synthesis,spectral account and catalytic features

Zeolite-Y enslaved complexes were prepared by the Flexible ligand method. Synthesized materials were characterized by various spectral tools like powder X-ray diffraction, spectral studies (UV–Vis and FT-IR), chemical analysis (ICP-OES and elemental), scanning electron microscopy, AAS and ¹H-NMR techniques. Further, BET and thermogravimetric (TG) analysis were also done for characterization of surface area, pore volume, thermal behavior, and related parameters. Baeyer–Villiger oxidation of cyclohexanone was carried out over Zeolite-Y enslaved complexes using hydrogen peroxide (H₂O₂) as an oxidant. The performance of the heterogeneous system with the homogeneous system was compared to determine the protection effect of the zeolitic matrix over the active center on the catalytic properties. In addition, the effect of experimental variables (various solvents, amount of catalyst, the mole ratio of substrate and oxidant, temperature, and reaction time) was examined in order to get absolute reaction conditions. Under the optimized reaction conditions, [Fe(nbab)₂]-Y was found to be a potential candidate, achieving 70 % ?-caprolactone selectivity.     

A sub-space method to detect multiple wireless microphone signals in TV band white space

The main hurdle in the realization of dynamic spectrum access systems from the physical layer perspective is the reliable sensing of low power licensed users. One such scenario shows up in the unlicensed use of the TV bands where the TV band devices are required to sense extremely low power wireless microphones (WMs). The lack of technical standards among various wireless manufacturers and the resemblance of certain WM signals to narrow-band interference signals, such as spurious emissions, further aggravate the problem. Due to these uncertainties, it is extremely difficult to abstract the features of WM signals and hence develop robust sensing algorithms. To partly counter these challenges, we develop a two-stage sub-space algorithm that detects multiple narrow-band analog frequency-modulated signals generated by WMs. The performance of the algorithm is verified by using the real WM signals experimentally captured under low SNR conditions. The problem of differentiating between the WM and other narrow-band signals is left as future work.     

Study of Temperature Dependence of Electrode–Glass Ceramic Interface Using Impedance Spectroscopy

The electrical behavior of strontium titanate borosilicate glass ceramics (SrO.TiO₂- 2SiO₂.B₂O₃) with additives K₂O, La₂O₃, CoO and Nb₂O₅ was studied by using Impedance Spectroscopy as a function of temperature and composition. An equivalent circuit model having three parallel RC's connected in series with a capacitor C₄ could represent the data well. By comparing the complex modulus plots with simulated ones and looking at the values of the time constants these RC's were attributed to represent crystalline, glassy and glass-crystal interface regions of the glass- ceramic whereas C₄ represented the glass-ceramic sample and contact electrode interface. When the glass ceramic sample contained only SrTiO₃ crystalline phase and the remaining glassy matrix, the interface capacitance showed an Arrhenius type of nature with an activation energy (0.11 ± 0.04) eV and when the glass- ceramic sample contained number of crystalline phases no clear cut trend appeared. These findings are useful in selecting suitable electrodes for applications as well as in deciding upon experimental techniques for measurement of dielectric constants of materials.     

On the Effect of Birefringence on Light Transmission in Polycrystalline Magnesium Fluoride

Light transmission in polycrystalline magnesium fluoride was studied as a function of the mean grain size at different wavelengths. The mean grain size was varied by annealing hot‐pressed billets in argon atmosphere at temperatures ranging from 600°C to 800°C for 1 h. The grain‐size and grain‐orientation distributions were characterized by electron back scatter diffraction. The scattering coefficients were calculated from the in‐line transmittance measured at various wavelengths. The scattering coefficient of polycrystalline magnesium fluoride increased linearly with the mean grain size and inversely with the square of the wavelength of light. It is shown that these trends are consistent with theoretical models based on both a limiting form of the Raleigh–Gans–Debye (RGD) theory of particle scattering and light retardation theories that take refractive index variations along the light path. Quantitative predictions of the theories are, however, subject to uncertainly due to the restrictive assumptions made in the theories and difficulties in representing the microstructure in the theoretical models. In particular, grain‐size distribution has a significant influence on the scattering coefficient calculated using particle scattering models.     

Effect of roughness height ratio in V down perforated baffle roughness on thermohydraulic performance of solar air heater: an experimental study

A substantial improvement in the thermal performance of solar air heater is found by using roughness on the underside of the absorber plate. In the present investigation, the effect of relative roughness height of roughness element on the thermohydraulic performance of solar air heaters is carried out. The range of roughness and flow parameters for the investigation are relative roughness height (e/H): 0.285–0.6, relative roughness pitch (P/e): 2, angle of attack (α): 60°, open area ratio (β): 12% and Reynolds number (Re): 3800–19,000. The relative roughness height of 0.285 is thermohydraulically better in comparison to other relative roughness heights. The results show that the V down perforated baffles is thermohydraulically better than the solid baffles.     

An Assessment of the Applicability of Particle Light Scattering Theories to Birefringent Polycrystalline Ceramics

The applicability of particle light scattering theories to light attenuation in birefringent polycrystalline ceramics was investigated by measuring light transmittance in a model two‐phase system. The system consisted of microspheres of silica dispersed in a solution of glycerol in water. The composition of the liquid medium was chosen to produce a mismatch between the refractive index of the particles (n_p) and of the medium (n_m) equal to the root mean square of the refractive index variation in polycrystalline magnesium fluoride. The variations of the scattering coefficients (γ) with volume fraction of silica microspheres for three different particle diameters (0.5, 1.0 and 1.5 μm) were compared with theoretical predictions based on scattering efficiency of single particles (K) and linear extrapolation to multiparticle dispersed systems. The measured scattering coefficients were significantly greater than the theoretical values for particle volume fractions greater than 0.2. These results suggest that application of particle scattering theories to a birefringent polycrystalline ceramic, an intrinsically high volume fraction system, is tenuous at best.     

A Functionally Graded Carbide in the Ta–C System

Hard materials used in such abrasive wear applications as cutting tools and wear inserts in drilling tools require high hardness to resist wear, high fracture toughness to withstand mechanical and thermal shock, and high chemical and thermal stability. Such a combination of properties is difficult to achieve in single‐phase materials. Functional grading is an approach that overcomes this limitation by designing and processing a graded microstructure that provides high hardness and chemical resistance at the surface with a tough interior or bulk. While functional grading is a widely used practice in the cemented carbides industry, it has not been demonstrated with “pure” carbides. This article reports the feasibility of designing and processing a graded carbide in the Ta–C binary system. It is shown that a simple carburization treatment of the high‐toughness carbide, ζ‐Ta₄C_3?x, can lead to the formation of the hard carbide phase, γ‐TaC_y, on the surface. The thickness, microstructure (grain size), and composition (C/Ta atomic ratio, y) of the γ‐TaC_y layer can be optimized to obtain both high hardness and high strength for the graded material.