Iterative sound synthesis by means of cross-coupled digital oscillators

Abstract

Musicians have long been interested in using iterative processes to aid the composition of musical forms (macrostructure) and to synthesize sounds (microstructure). This paper introduces a new sound synthesis method exploring the non-linear behaviour of two iterative cross-coupled digital oscillators. It begins with a brief introduction to iterative systems followed by background information on previous attempts at using them for synthesizing sounds (e.g. feedback frequency and amplitude modulations). Next, it introduces our synthesis method and briefly explains how it has been implemented in a system for real-time composition and performance. The paper concludes with a discussion on how the system has been put into practice to compose and perform a number of works.     

Augmented reality annotations to assist persons with Alzheimers and their caregivers

Persons with Alzheimer’s disease (AD) and their caregivers implement diverse strategies to cope with memory loss. A common strategy involves placing tags on drawers or removing cabinet doors to make their contents visible. This study describes the Ambient aNnotation System (ANS), aimed at assisting people suffering from AD and their caregivers with this task. The system has two main modules: The tagging subsystem allows caregivers to create and manage ambient annotations in order to assist people with memory problems. The second subsystem allows people with AD to use a mobile phone to recognize tags in the environment and to receive relevant information in the form of audio, text, or images. The identification of these tags is performed in real time by uploading images from the mobile phone to a server, which uses the SURF algorithm for object recognition. We describe the design and implementation of the system as well as results of the evaluation of its performance and efficiency. ANS can process query images approximately every 2 s and is able to locate users in their homes with a precision of 0.93. A usability study conducted with six subjects determined that audio notifications are more effective than vibrating notifications to alert the user about tags in the environment.     

Generalized Hermitian Radial Basis Functions Implicits from polygonal mesh constraints

In this work we investigate a generalized interpolation approach using radial basis functions to reconstruct implicit surfaces from polygonal meshes. With this method, the user can define with great flexibility three sets of constraint interpolants: points, normals, and tangents; allowing to balance computational complexity, precision, and feature modeling. Furthermore, this flexibility makes possible to avoid untrustworthy information, such as normals estimated on triangles with bad aspect ratio. We present results of the method for applications related to the problem of modeling 2D curves from polygons and 3D surfaces from polygonal meshes. We also apply the method to problems involving subdivision surfaces and front-tracking of moving boundaries. Finally, as our technique generalizes the recently proposed HRBF Implicits technique, comparisons with this approach are also conducted.     

Variable-order fractional derivatives and their numerical approximations

This paper addresses the different possible definitions of variable-order derivatives and their numerical approximations; both approximations based upon the definitions and approximations consisting of non-linear transfer functions (in particular combining existing approximations of constant-order fractional derivatives, such as the Crone approximation, with fuzzy logic) are considered. There are different possible configurations, implementing variable-order fractional derivatives both with and without memory of past values of the time-dependent differentiation order.     

High-resolution imaging of the immunological synapse and T-cell receptor microclustering through microfabricated substrates

T-cell activation via antigen presentation is associated with the formation of a macromolecular membrane assembly termed the immunological synapse (IS). The genesis of the IS and the onset of juxtacrine signalling is characterized by the formation of cell membrane microclusters and the organization of such into segregated microdomains. A central zone rich in T-cell receptor (TCR)–major histocompatibility complex microclusters termed the central supramolecular activation cluster (cSMAC) forms the bullseye of this structure, while the cellular interface surrounding the cSMAC is characterized by regions enriched in adhesion and co-stimulatory molecules. In vitro, the study of dynamic TCR microcluster coalescence and IS genesis in T-cell populations is hampered by cell migration within the culture system and resolution constraints resulting from lateral cell–cell contact. Here, we detail a novel system describing the fabrication of micropit arrays designed to sequester single T-cell–antigen presenting cell (APC) conjugates and promote IS formation in the horizontal imaging plane for high-resolution studies of microcluster dynamics. We subsequently use this system to describe the formation of the cSMAC in T-cell populations and to investigate the morphology of the interfacial APC membrane.     

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

The identification and production of recombinant morphogens and growth factors that play key roles in tissue regeneration have generated much enthusiasm and numerous clinical trials, but the results of many of these trials have been largely disappointing. Interestingly, the trials that have shown benefit all contain a common denominator, the presence of a material carrier, suggesting strongly that spatio-temporal control over the location and bioactivity of factors after introduction into the body is crucial to achieve tangible therapeutic effect. Sophisticated materials systems that regulate the biological presentation of growth factors represent an attractive new generation of therapeutic agents for the treatment of a wide variety of diseases. This review provides an overview of growth factor delivery in tissue engineering. Certain fundamental issues and design strategies relevant to the material carriers that are being actively pursued to address specific technical objectives are discussed. Recent progress highlights the importance of materials science and engineering in growth factor delivery approaches to regenerative medicine.     

Formalising the Fisherman's Folly puzzle

This paper investigates the challenging problem of encoding the common sense knowledge involved in the manipulation of spatial objects from a reasoning about actions and change perspective. In particular, we propose a formal solution to a puzzle composed of non-trivial objects (such as holes and strings) assuming a version of the Situation Calculus written over first-order Equilibrium Logic, whose models generalise the stable model semantics.     

Constrained scheduling of the inspection activities on semiconductor wafers grouped in families with sequence-dependent set-up times

The scheduling of families of semiconductor wafers within the inspection department of a company producing electronic devices is considered in this paper. Changing the family of wafers to be inspected by an inspection machine requires a sequence-dependent set-up time; furthermore, due to the limited space availability of the inspection area, the available interoperational buffer capacity between the inspection machines is finite. The objective of the scheduling is the maximization of inspection department productivity, measured through the sequence makespan. A permutational flowshop group-scheduling problem (GSP) with sequence-dependent set-up times and limited interoperational buffer capacity has been taken into account. A benchmark of process scenarios considering different numbers of inspection machines wafers codes and families to be inspected has been generated. A Genetic Algorithm is here proposed as an efficient tool to solve the investigated problem. A comparison with a tabu search and a Nawaz, Enscore, and Ham procedure improving the currently available scheduler tool within the inspection department has been performed on the benchmark of problems. Finally, the influence on line productivity due to the finite interoperational buffer capacity is investigated.