Scale and scope of environmental planning transformations: The Israeli case

This paper explores the scale and scope of transformations in the environmental planning field, and the factors that may advance or impede their widespread adoption. A conceptual model is offered which examines scope (defined as type, breadth and structure of the transformation), and the scale of its impact (categorized as stakeholder, organizational, institutional or societal) and applies it to the analysis of several cases in Israel where environmental transformations, affecting the way in which planning is conducted, have been adopted. Conclusions include identification of conditions for facilitating and advancing transformations, including knowledge of innovative alternatives, initiative, willingness to adopt new practices, and identification of policy windows that emerge during conflict, reform, or crisis. The fostering of relations between environmental non-government organizations and planning systems and leadership roles are also significant in catalyzing environmental transformation.     

Systems analysis utilising pathway interactions identifies sonic hedgehog pathway as a primary biomarker and oncogenic target in hepatocellular carcinoma

The development and progression of cancer is associated with disruption of biological networks. Historically studies have identified sets of signature genes involved in events ultimately leading to the development of cancer. Identification of such sets does not indicate which biologic processes are oncogenic drivers and makes it difficult to identify key networks to target for interventions. Using a comprehensive, integrated computational approach, the authors identify the sonic hedgehog (SHH) pathway as the gene network that most significantly distinguishes tumour and tumour‐adjacent samples in human hepatocellular carcinoma (HCC). The analysis reveals that the SHH pathway is commonly activated in the tumour samples and its activity most significantly differentiates tumour from the non‐tumour samples. The authors experimentally validate these in silico findings in the same biologic material using Western blot analysis. This analysis reveals that the expression levels of SHH, phosphorylated cyclin B1, and CDK7 levels are much higher in most tumour tissues as compared to normal tissue. It is also shown that siRNA‐mediated silencing of SHH gene expression resulted in a significant reduction of cell proliferation in a liver cancer cell line, SNU449 indicating that SHH plays a major role in promoting cell proliferation in liver cancer. The SHH pathway is a key network underpinning HCC aetiology which may guide the development of interventions for this most common form of human liver cancer.Inspec keywords: bioinformatics, cancer, cellular biophysics, genetics, liver, molecular biophysics, RNA, systems analysis, tumoursOther keywords: biomedical informatics, human liver cancer, network underpinning HCC aetiology, liver cancer cell line, cell proliferation, SHH gene expression, siRNA‐mediated silencing, CDK7 levels, phosphorylated cyclin B1, Western blot analysis, in silico findings, SHH pathway, human hepatocellular carcinoma, tumour‐adjacent samples, gene network, integrated computational approach, oncogenic drivers, biologic processes, cancer development, biological networks, cancer progression, oncogenic target, primary biomarker, sonic hedgehog pathway, pathway interactions, systems analysis     

Underground Mining of Kimberlite Pipes under Alluvia

The scheme is proposed for underground mining of kimberlite pipe under alluvia 80-100 m in thickness. The main features of the technology are the refusal to carry out filling operations and use ore vibration discharge ensuring its simultaneous flow over the pipe cross-section.     

On the Effective Deployment of Functional Formal Verification

We examine IBM's exploitation of formal verification using RuleBase—a formal verification tool developed by the IBM Haifa Research Laboratory. The goal of the paper is methodological. We identify an integrated methodology for the deployment of formal verification which involves three complementary modes: architectural verification, block-level verification, and design exploration.     

Redundancy gains for visual search after complete commissurotomy.

Redundant-targets effects (RTE) for visual search were investigated in 2 commissurotomy patients (L.B., N.G.). L.B., who showed no evidence of visual interhemispheric transfer, exhibited a paradoxical enhancement of the redundancy gain in the bilateral compared with the within-hemifield redundant-targets conditions, whereas N.G., who showed evidence of interhemispheric transfer of visual information, exhibited no enhancement of the bilateral redundancy gain. When only uncrossed responses were considered, both bilateral and within-field RTE were evident only when attentional demands were high. Bilateral redundant targets led to stronger gains, some indicative of coactivation, in the slower response hand. The authors suggest that the enhancement of the bilateral RTE comes about by neural coactivation, which is especially pronounced when the slower hemisphere elicits the response. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Short- and long-term effects of fraternity and sorority membership on heavy drinking: A social norms perspective.

This study sought to determine whether the well-established relation between fraternity/sorority (Greek) membership and heavy alcohol use persists beyond the college years and whether some common third variables might account for the relation between Greek status and heavy drinking. During each of 4 years of college and 1 additional year, young adults (N ?=?319) completed measures of alcohol use, personality, alcohol expectancies, and environmental influences on drinking. Throughout the college years, Greeks consistently drank more heavily than non-Greeks. Statistically controlling for previous alcohol use did not eliminate this effect. However, Greek status did not predict postcollege heavy drinking levels. Also, perceived peer norms for heavy drinking mediated the relation between Greek affiliation and heavy alcohol use. Results are discussed in terms of situational determinants of heavy alcohol involvement in young adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Communication patterns and response to treatment among depressed and nondepressed maritally distressed couples.

Compared 35 maritally distressed couples assigned to 1 of 3 cognitive behavioral marital therapy (BMT) groups. Groups represented (1) couples in which 1 spouse was depressed at pretest, (2) couples in which 1 spouse showed psychopathology other than depression, and (3) couples who showed no symptoms of individual psychopathology. Ss were administered, pre- and posttreatment, the Dyadic Adjustment Scale and the Minnesota Multiphasic Personality Inventory (MMPI). Pretreatment couples in Group 1 were the oldest and the least maritally satisfied, and expressed the most negative communication. 12 wks of BMT was an effective treatment modality for all groups when compared with a group of 12 couples on a wait list. BMT significantly increased marital adjustment for all 3 treatment groups and decreased the rates of negative communication. BMT significantly decreased the level of depression in Group 1 and the level of psychopathology in Group 2. (PsycINFO Database Record (c) 2010 APA, all rights reserved)