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991.
992.
L.F. Greco J.T. Neves Neto A. Pedrico F.S. Lima R.S. Bisinotto N. Martinez E.S. Ribeiro W.W. Thatcher C.R. Staples J.E.P. Santos 《Journal of dairy science》2018,101(11):10536-10556
Objectives were to evaluate the effects of altering the dietary ratio of omega-6 (n-6) to omega-3 (n-3) fatty acids on the profile of fatty acids and expression of genes related to the prostaglandin biosynthesis on endometrial tissue, uterine secretion of PGF2α, and timing of spontaneous luteolysis in dairy cows. Multiparous lactating Holstein cows (n = 45) were blocked based on milk yield and, within each block, assigned randomly to 1 of 3 dietary treatments at 14 d postpartum for 90 d. Diets were supplemented with a mixture of Ca salts of fish, safflower, and palm oils to create 3 different ratios of n-6 to n-3 fatty acids, namely R4, R5, and R6, which resulted in 3.9, 4.9, and 5.9 parts of n-6 to 1 part of n-3 fatty acids, respectively. Blood was sampled every 2 h from d 16 to 23 of the estrous cycle and assayed for concentrations of progesterone and the PGF2α metabolite 13,14-dihydro-15-keto-PGF2α (PGFM). In a subsequent estrous cycle, endometrial tissue was collected for biopsy on d 8 and endometrial fatty acids profile and gene expression were quantified. The proportion of arachidonic acid of the endometrial fatty acids increased as the dietary ratio n-6 to n-3 fatty acids increased (R4 = 9.05, R5 = 11.64, and R6 = 13.41%). On the other hand, proportions of eicosapentaenoic (R4 = 2.85, R5 = 2.14, and R6 = 2.02%) and docosahexaenoic (R4 = 3.30, R5 = 1.57, and R6 = 1.08%) decreased as the ratio of n-6 to n-3 fatty acids in the diet increased. Increasing the ratio of dietary n-6 to n-3 fatty acids increased mRNA expression of estrogen receptor 1, oxytocin receptor, cyclooxygenase 2, prostaglandin E and F synthases, and steroidogenic acute regulatory protein in endometrium, but decreased expression of peroxisome proliferator-activated receptor gamma and insulin-like growth factor-1. The changes in endometrium gene expression caused by dietary treatments were associated with changes in the ratio of n-6 to n-3 fatty acids in the endometrium. As the ratio increased from R4 to R6, the number of PGFM pulses (R4 = 5.6, R5 = 4.3, and R6 = 3.8 ± 0.6 pulses; least squares means ± standard error of the means) decreased, but the amplitude of the greatest PGFM pulse increased (R4 = 226, R5 = 267, and R6 = 369 ± 38 pg/mL). Luteolysis by d 23 of the estrous cycle was observed in 79.6% of the cows (R4 = 11/14; R5 = 13/15; and R6 = 11/15) and day of spontaneous luteolysis did not differ among treatments (R4 = 20.8; R5 = 21.1; and R6 = 21.0 ± 0.4). Three pulses of PGFM was the best predictor of luteolysis in dairy cows. Collectively, supplying the same quantity of fatty acids in the diet of lactating dairy cows, but altering the ratio of n-6 to n-3 fatty acids, influenced the endometrial fatty acids profile and gene expression and altered the pattern of prostaglandin synthesis; however, the changes were not sufficient to alter the length of the estrous cycle. 相似文献
993.
Mayara dos Santos Amarante Sabrina Morais da Silva João Paulo Barros Machado Manuel Henrique Lente Adriana Maria da Silva Vera Lúcia Othéro de Brito 《Ceramics International》2021,47(9):12600-12612
Particulate magnetoelectric ceramic composites (PMCC) have received much attention since the last decade. These composites have many technological applications and are usually composed by magnetostrictive and piezoelectric phases. Cobalt-based spinel ferrites are among the most studied magnetostrictive phases for ferrite-based PMCCs and BaTiO3 is an interesting choice for the piezoelectric phase because it is a lead-free ceramic, unlike the traditional PZT. In this work, cobalt ferrite (FCO) and Ni–Co ferrite (FNICO) were produced by the ceramic method and mixed to BaTiO3 (TB) in order to further obtain sintered ferrite-BaTiO3 particulate ceramic composites with a composition of 15 mol% ferrite – 85 mol% BaTiO3. The ferrites, the BaTiO3, and the ferrite-BaTiO3 mixtures were analyzed by dilatometry, thermogravimetry (TG), and calorimetry (DSC) in temperatures up to 1300–1400 °C, with the aim to analyze the sintering behavior and the interactions between both ferrites and the BaTiO3 during sintering. Sintered TB-FNICO and TB-FCO composite samples were also produced and they were analyzed by scanning electron microscopy (SEM) and X-ray diffractometry (XRD). The dilatometry results evidenced that the densification of the ferrite-BaTiO3 samples is impaired, when compared to the pure ferrite and BaTiO3 samples. The DSC/TG results evidenced the occurrence of reactions between the ferrites and the BaTiO3 when they are co-sintered in air or argon atmospheres. The XRD patterns of the sintered composite samples did not exhibit diffraction peaks attributed to a third phase, whilst the punctual EDS analysis showed evidence of diffusion between the ferrite and BaTiO3 particles. 相似文献
994.
995.
Alex Hirtz Fabien Rech Hlne Dubois-Pot-Schneider Hlne Dumond 《International journal of molecular sciences》2020,21(23)
Astrocytomas and, in particular, their most severe form, glioblastoma, are the most aggressive primary brain tumors and those with the poorest vital prognosis. Standard treatment only slightly improves patient survival. Therefore, new therapies are needed. Very few risk factors have been clearly identified but many epidemiological studies have reported a higher incidence in men than women with a sex ratio of 1:4. Based on these observations, it has been proposed that the neurosteroids and especially the estrogens found in higher concentrations in women’s brains could, in part, explain this difference. Estrogens can bind to nuclear or membrane receptors and potentially stimulate many different interconnected signaling pathways. The study of these receptors is even more complex since many isoforms are produced from each estrogen receptor encoding gene through alternative promoter usage or splicing, with each of them potentially having a specific role in the cell. The purpose of this review is to discuss recent data supporting the involvement of steroids during gliomagenesis and to focus on the potential neuroprotective role as well as the mechanisms of action of estrogens in gliomas. 相似文献
996.
997.
Sibele Santos Fernandes Leonardo Greque Maria de Fatima C. Santos Leice M. R. de Novais Caroline D. R. M. D'Oca Carlos Prentice Myriam de las M. Salas-Mellado 《应用聚合物科学杂志》2021,138(39):51015
Chia oil has a high content of linolenic and linoleic acids, which are essential for the human body. However, their high degree of unsaturation (double bonds) makes the oil very susceptible to oxidation. In this context, the use of spray drying can be useful strategy to minimize the oxidation of this oil. Thus, the aim was to assess the effects of inlet temperature and feed rate conditions involved in the spray drying process on the physicochemical and morphological characteristics, and stability of the chia oil microparticles with maltodextrin and GA. The microparticles were obtained with a yield of 50%, encapsulation efficiency greater than 87%, low-moisture content, and mean particle sizes ranging from 3.01 to 4.11 μm. The thermal evaluation and storage evidenced an increase in stability. The 1H HR-MAS NMR technique showed that the microparticles maintained the characteristic fatty acid profile of chia oil and seeds. Results indicate that the microencapsulation methodology was suitable for preparing microparticles containing chia oil. 相似文献
998.
Philipe A. P. Silva Aline Bruna da Silva João Paulo Ferreira Santos Rodrigo Lambert Oréfice 《应用聚合物科学杂志》2021,138(14):50148
In this work, novel immiscible polymer blends with remarkable self-healing properties were developed. The blends are based on poly(ethylene glycol-co-cyclohexane-1,4-dimethanol terephthalate) (PETG), a nonself-healing polymer, and the ionomer sodium-neutralized poly(ethylene-co-methacrylic acid) (EMAA), with self-healing abilities. The ratios of (PETG)/ (EMAA) was varied from 0 to 100% (w/w) and mixtures were prepared using a twin-screw melt extrusion. The blend studied compositions were characterized by scanning electron microscope, differential scanning calorimetry, dynamic mechanical analysis and self-repair tests. The results revealed that blends samples were able to self-repair damages created by Vickers microhardness indentations. The self-repair is presented through video records where the establishment of scars in the damaged area can be observed. For the composition 50/50 (w/w), the whole repair was observed due the synergic effect between polymer chain mobility, new chemical interactions promoted between PETG and EMAA, thus improving its self-healing ability. 相似文献
999.
Mateus Wagner Dantas de Assis Gustavo Walace Pacheco Leite Luis Carlos Cunha Júnior Renato de Mello Prado Edson Perito Amorim João Paixão dos Santos Neto Lívia Cirino de Carvalho Gustavo Henrique de Almeida Teixeira 《International Journal of Food Science & Technology》2020,55(7):2893-2900
Due to the importance of banana consumption in developing countries and producing zinc-rich foods, the objective of this study was to evaluate the feasibility of banana bunch sprays and bunch stalk feeding with Zn aiming to biofortify this fruit. Zn sprays were carried out with a dose of 80 g ha−1 using ZnCl2 and ZnCl2 combined with a chelating agent in two banana cultivars (‘Maravilha’ and ‘FHIA 18’). Bunch stalk feeding with Zn was carried out by fixing plastic bags on the stem end containing solutions of ZnSO4 (0, 0.5, 1.0 and 2.0 g L−1) in two banana cultivars (‘Williams’ and ‘Prata Anã’). Both strategies resulted in a maximum fruit Zn content of 0.14 mg 100 g−1. Although it was possible to increase the Zn content in banana fruit from ‘FHIA 18’ and ‘Prata Anã’ cultivars, both strategies did not result in biofortified banana fruit with a Zn level which would fulfil the Zn dietary reference intake (DRI) of 2 mg dia−1 for children. Banana bunch sprays with Zn did not affect the fruit quality, but bunch stalk feeding with Zn resulted in fruits with lower ratio, pH and ascorbic acid content. 相似文献